Microgravity's effects on miRNA-mRNA regulatory networks in a mouse model of segmental bone defects.

Microgravity's effects on miRNA-mRNA regulatory networks in a mouse model of segmental bone defects.

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Rehabilitation from musculoskeletal injuries (MSKI) complicate healing dynamics typically by sustained disuse of bone and muscles. Microgravity naturally allows limb disuse and thus an effective model to understand MSKI. The current study examined epigenetic changes in a segmental bone defect (SBD)...

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Bibliographic Details
Main Authors: Aarti Gautam, Nabarun Chakraborty, George Dimitrov, Allison Hoke, Stacy Ann Miller, Kevin Swift, Bintu Sowe, Carolynn Conley, Melissa A Kacena, Rasha Hammamieh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0313768
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