A Systematic Review Exploring Empirical Pharmacogenomics Research Within Global Indigenous Populations
ABSTRACT Background This systematic review aims to highlight the scope of pharmacogenomics research within global Indigenous populations. This review also explores the barriers and facilitators of pharmacogenomics research within this population. Methodology A systematic review of literature was con...
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| Format: | Article |
| Language: | English |
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Wiley
2024-10-01
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| Series: | Molecular Genetics & Genomic Medicine |
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| Online Access: | https://doi.org/10.1002/mgg3.70018 |
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| author | Bushra Farah Nasir Ritwika Vinayagam Luciana Massi Shivashankar H. Nagaraj Maree Toombs Kym M. Rae |
| author_facet | Bushra Farah Nasir Ritwika Vinayagam Luciana Massi Shivashankar H. Nagaraj Maree Toombs Kym M. Rae |
| author_sort | Bushra Farah Nasir |
| collection | DOAJ |
| description | ABSTRACT Background This systematic review aims to highlight the scope of pharmacogenomics research within global Indigenous populations. This review also explores the barriers and facilitators of pharmacogenomics research within this population. Methodology A systematic review of literature was conducted to identify and present an understanding of current empirical evidence demonstrating the conduct of genomics or pharmacogenomics research within global Indigenous populations (PROSPERO registration: CRD42021257226). Using key search terms, relevant databases were searched for articles published between January 2010 and July 2022. Screening, data extraction, and analysis was conducted using well‐defined inclusion criteria. Quality assessment and risk of bias appraisal was conducted using the mixed methods appraisal tool. Indigenous community engagement and participation in genomics research was assessed using the social‐ecological framework. Results From the 427 articles identified, 77 articles met inclusion criteria and underwent full‐text screening. Of these, 30 articles were included in the final review, with 16 being quantitative and 14 either qualitative or mixed methods studies. Most studies were conducted with native Indigenous populations from the United States of America (36%). Content analysis revealed that studies either explored genetic variations associated with disease in Indigenous populations (23%) or markers for drug metabolism (30%) or were designed to understand perspectives of genomics research within this population (47%). Perspectives included the exploration of the role of participants in research, benefits or outcomes achieved from participation in genomics research, and levels of Indigenous engagement and participation in genomics research. Conclusions This review highlights a growing gap in Indigenous genomics research globally. It presents several important considerations from Indigenous participants, identifying how researchers can co‐create culturally safe and inclusive design, implementation, analysis, and subsequent outcomes of genomics research involving Indigenous people. Indigenous governance, self‐determination and leadership is essential, with researchers required to be responsive to such fundamental partnerships for research to progress. |
| format | Article |
| id | doaj-art-feec49f2c7764e68b0b2dd9332c8d027 |
| institution | OA Journals |
| issn | 2324-9269 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Molecular Genetics & Genomic Medicine |
| spelling | doaj-art-feec49f2c7764e68b0b2dd9332c8d0272025-08-20T02:12:01ZengWileyMolecular Genetics & Genomic Medicine2324-92692024-10-011210n/an/a10.1002/mgg3.70018A Systematic Review Exploring Empirical Pharmacogenomics Research Within Global Indigenous PopulationsBushra Farah Nasir0Ritwika Vinayagam1Luciana Massi2Shivashankar H. Nagaraj3Maree Toombs4Kym M. Rae5Toowoomba Regional Clinical Unit, Medical School, Faculty of Medicine The University of Queensland Toowoomba Queensland AustraliaSchool of Public Health, Faculty of Medicine The University of Queensland Brisbane Queensland AustraliaMater Research Institute The University of Queensland Brisbane Queensland AustraliaCentre for Genomics and Personalised Health and the School of Biomedical Sciences Queensland University of Technology Brisbane Queensland AustraliaSchool of Population Health, Faculty of Medicine and Health The University of New South Wales Sydney New South Wales AustraliaMater Research Institute The University of Queensland Brisbane Queensland AustraliaABSTRACT Background This systematic review aims to highlight the scope of pharmacogenomics research within global Indigenous populations. This review also explores the barriers and facilitators of pharmacogenomics research within this population. Methodology A systematic review of literature was conducted to identify and present an understanding of current empirical evidence demonstrating the conduct of genomics or pharmacogenomics research within global Indigenous populations (PROSPERO registration: CRD42021257226). Using key search terms, relevant databases were searched for articles published between January 2010 and July 2022. Screening, data extraction, and analysis was conducted using well‐defined inclusion criteria. Quality assessment and risk of bias appraisal was conducted using the mixed methods appraisal tool. Indigenous community engagement and participation in genomics research was assessed using the social‐ecological framework. Results From the 427 articles identified, 77 articles met inclusion criteria and underwent full‐text screening. Of these, 30 articles were included in the final review, with 16 being quantitative and 14 either qualitative or mixed methods studies. Most studies were conducted with native Indigenous populations from the United States of America (36%). Content analysis revealed that studies either explored genetic variations associated with disease in Indigenous populations (23%) or markers for drug metabolism (30%) or were designed to understand perspectives of genomics research within this population (47%). Perspectives included the exploration of the role of participants in research, benefits or outcomes achieved from participation in genomics research, and levels of Indigenous engagement and participation in genomics research. Conclusions This review highlights a growing gap in Indigenous genomics research globally. It presents several important considerations from Indigenous participants, identifying how researchers can co‐create culturally safe and inclusive design, implementation, analysis, and subsequent outcomes of genomics research involving Indigenous people. Indigenous governance, self‐determination and leadership is essential, with researchers required to be responsive to such fundamental partnerships for research to progress.https://doi.org/10.1002/mgg3.70018genomicsindigenous genomics researchpharmacogenomics |
| spellingShingle | Bushra Farah Nasir Ritwika Vinayagam Luciana Massi Shivashankar H. Nagaraj Maree Toombs Kym M. Rae A Systematic Review Exploring Empirical Pharmacogenomics Research Within Global Indigenous Populations Molecular Genetics & Genomic Medicine genomics indigenous genomics research pharmacogenomics |
| title | A Systematic Review Exploring Empirical Pharmacogenomics Research Within Global Indigenous Populations |
| title_full | A Systematic Review Exploring Empirical Pharmacogenomics Research Within Global Indigenous Populations |
| title_fullStr | A Systematic Review Exploring Empirical Pharmacogenomics Research Within Global Indigenous Populations |
| title_full_unstemmed | A Systematic Review Exploring Empirical Pharmacogenomics Research Within Global Indigenous Populations |
| title_short | A Systematic Review Exploring Empirical Pharmacogenomics Research Within Global Indigenous Populations |
| title_sort | systematic review exploring empirical pharmacogenomics research within global indigenous populations |
| topic | genomics indigenous genomics research pharmacogenomics |
| url | https://doi.org/10.1002/mgg3.70018 |
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