Exploring the efficacy and safety of laparoscopic liver resection in the treatment of early-stage male patients with liver cancer and tumor diameter ≤5 cm
Background: This study investigates the efficacy and safety of laparoscopic hepatectomy in male patients with hepatocellular carcinoma (HCC) and tumor diameter ≤5 cm. Methods: The clinical data of 100 male HCC patients treated at our hospital from January 2019 to January 2021 were retrospectivel...
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| Language: | English |
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MRE Press
2025-05-01
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| Series: | Journal of Men's Health |
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| Online Access: | https://oss.jomh.org/files/article/20250530-553/pdf/JOMH2025022701.pdf |
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| author | Shipeng Cui |
| author_facet | Shipeng Cui |
| author_sort | Shipeng Cui |
| collection | DOAJ |
| description | Background: This study investigates the efficacy and safety of
laparoscopic hepatectomy in male patients with hepatocellular carcinoma (HCC) and
tumor diameter ≤5 cm. Methods: The clinical data of 100 male HCC
patients treated at our hospital from January 2019 to January 2021 were
retrospectively collected. According to the treatment methods, patients were
divided into an observation group (50 cases) and a control group (50 cases). The
control group underwent traditional open non-anatomical liver resection, while
the observation group received laparoscopic non-anatomical liver resection. The
safety and efficacy of the two surgical methods were compared. Results:
The observation group demonstrated significantly reduced
intraoperative blood loss, operation time, incision length, and hepatic portal
occlusion time than the control group (p < 0.001). The observation
group had shorter times to mobilization, initiation of oral feeding, and hospital
discharge (p < 0.001). On postoperative day three,
levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and
total bilirubin (TBIL) were significantly lower in the observation group
(p < 0.05). Cluster of Differentiation 3+ (CD3+), CD4+,
CD8+, and CD4+/CD8+ ratio were improved in the observation group
one week post-surgery (p < 0.05). The complication rate was
significantly lower in the observation group (p < 0.05). At 1 and 3
years post-surgery, the recurrence rate in the observation group was
significantly lower (p < 0.05). The overall survival (OS) rates at
one, two, and three years were 75.9%, 41.4% and 12.9% for the observation
group and 55.5%, 14.4% and 0% for the control group (p < 0.05),
respectively. The median survival times in the observation group was
significantly longer than the control group (p < 0.05).
Conclusions: Laparoscopic hepatectomy for HCC offers improved
clinical outcomes, enhanced liver function, reduced complication rates, and
favorable safety profiles compared to open hepatectomy. |
| format | Article |
| id | doaj-art-fee8f788c25d4e0184dce467f3200431 |
| institution | OA Journals |
| issn | 1875-6867 1875-6859 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MRE Press |
| record_format | Article |
| series | Journal of Men's Health |
| spelling | doaj-art-fee8f788c25d4e0184dce467f32004312025-08-20T02:08:50ZengMRE PressJournal of Men's Health1875-68671875-68592025-05-0121510311910.22514/jomh.2025.073S1875-6867(25)00390-2Exploring the efficacy and safety of laparoscopic liver resection in the treatment of early-stage male patients with liver cancer and tumor diameter ≤5 cmShipeng Cui0General Surgery, The First Affiliated Hospital of Soochow University, 215006 Suzhou, Jiangsu, ChinaBackground: This study investigates the efficacy and safety of laparoscopic hepatectomy in male patients with hepatocellular carcinoma (HCC) and tumor diameter ≤5 cm. Methods: The clinical data of 100 male HCC patients treated at our hospital from January 2019 to January 2021 were retrospectively collected. According to the treatment methods, patients were divided into an observation group (50 cases) and a control group (50 cases). The control group underwent traditional open non-anatomical liver resection, while the observation group received laparoscopic non-anatomical liver resection. The safety and efficacy of the two surgical methods were compared. Results: The observation group demonstrated significantly reduced intraoperative blood loss, operation time, incision length, and hepatic portal occlusion time than the control group (p < 0.001). The observation group had shorter times to mobilization, initiation of oral feeding, and hospital discharge (p < 0.001). On postoperative day three, levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total bilirubin (TBIL) were significantly lower in the observation group (p < 0.05). Cluster of Differentiation 3+ (CD3+), CD4+, CD8+, and CD4+/CD8+ ratio were improved in the observation group one week post-surgery (p < 0.05). The complication rate was significantly lower in the observation group (p < 0.05). At 1 and 3 years post-surgery, the recurrence rate in the observation group was significantly lower (p < 0.05). The overall survival (OS) rates at one, two, and three years were 75.9%, 41.4% and 12.9% for the observation group and 55.5%, 14.4% and 0% for the control group (p < 0.05), respectively. The median survival times in the observation group was significantly longer than the control group (p < 0.05). Conclusions: Laparoscopic hepatectomy for HCC offers improved clinical outcomes, enhanced liver function, reduced complication rates, and favorable safety profiles compared to open hepatectomy.https://oss.jomh.org/files/article/20250530-553/pdf/JOMH2025022701.pdflaparoscopic hepatectomyhepatocellular carcinomaopen hepatectomy |
| spellingShingle | Shipeng Cui Exploring the efficacy and safety of laparoscopic liver resection in the treatment of early-stage male patients with liver cancer and tumor diameter ≤5 cm Journal of Men's Health laparoscopic hepatectomy hepatocellular carcinoma open hepatectomy |
| title | Exploring the efficacy and safety of laparoscopic liver resection in the treatment of early-stage male patients with liver cancer and tumor diameter ≤5 cm |
| title_full | Exploring the efficacy and safety of laparoscopic liver resection in the treatment of early-stage male patients with liver cancer and tumor diameter ≤5 cm |
| title_fullStr | Exploring the efficacy and safety of laparoscopic liver resection in the treatment of early-stage male patients with liver cancer and tumor diameter ≤5 cm |
| title_full_unstemmed | Exploring the efficacy and safety of laparoscopic liver resection in the treatment of early-stage male patients with liver cancer and tumor diameter ≤5 cm |
| title_short | Exploring the efficacy and safety of laparoscopic liver resection in the treatment of early-stage male patients with liver cancer and tumor diameter ≤5 cm |
| title_sort | exploring the efficacy and safety of laparoscopic liver resection in the treatment of early stage male patients with liver cancer and tumor diameter ≤5 cm |
| topic | laparoscopic hepatectomy hepatocellular carcinoma open hepatectomy |
| url | https://oss.jomh.org/files/article/20250530-553/pdf/JOMH2025022701.pdf |
| work_keys_str_mv | AT shipengcui exploringtheefficacyandsafetyoflaparoscopicliverresectioninthetreatmentofearlystagemalepatientswithlivercancerandtumordiameter5cm |