Exploring the efficacy and safety of laparoscopic liver resection in the treatment of early-stage male patients with liver cancer and tumor diameter ≤5 cm
Background: This study investigates the efficacy and safety of laparoscopic hepatectomy in male patients with hepatocellular carcinoma (HCC) and tumor diameter ≤5 cm. Methods: The clinical data of 100 male HCC patients treated at our hospital from January 2019 to January 2021 were retrospectivel...
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| Format: | Article |
| Language: | English |
| Published: |
MRE Press
2025-05-01
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| Series: | Journal of Men's Health |
| Subjects: | |
| Online Access: | https://oss.jomh.org/files/article/20250530-553/pdf/JOMH2025022701.pdf |
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| Summary: | Background: This study investigates the efficacy and safety of
laparoscopic hepatectomy in male patients with hepatocellular carcinoma (HCC) and
tumor diameter ≤5 cm. Methods: The clinical data of 100 male HCC
patients treated at our hospital from January 2019 to January 2021 were
retrospectively collected. According to the treatment methods, patients were
divided into an observation group (50 cases) and a control group (50 cases). The
control group underwent traditional open non-anatomical liver resection, while
the observation group received laparoscopic non-anatomical liver resection. The
safety and efficacy of the two surgical methods were compared. Results:
The observation group demonstrated significantly reduced
intraoperative blood loss, operation time, incision length, and hepatic portal
occlusion time than the control group (p < 0.001). The observation
group had shorter times to mobilization, initiation of oral feeding, and hospital
discharge (p < 0.001). On postoperative day three,
levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and
total bilirubin (TBIL) were significantly lower in the observation group
(p < 0.05). Cluster of Differentiation 3+ (CD3+), CD4+,
CD8+, and CD4+/CD8+ ratio were improved in the observation group
one week post-surgery (p < 0.05). The complication rate was
significantly lower in the observation group (p < 0.05). At 1 and 3
years post-surgery, the recurrence rate in the observation group was
significantly lower (p < 0.05). The overall survival (OS) rates at
one, two, and three years were 75.9%, 41.4% and 12.9% for the observation
group and 55.5%, 14.4% and 0% for the control group (p < 0.05),
respectively. The median survival times in the observation group was
significantly longer than the control group (p < 0.05).
Conclusions: Laparoscopic hepatectomy for HCC offers improved
clinical outcomes, enhanced liver function, reduced complication rates, and
favorable safety profiles compared to open hepatectomy. |
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| ISSN: | 1875-6867 1875-6859 |