Analysis of the effects of eating and emotions on reproductive axis function in patients with functional hypothalamic amenorrhea
Objective: To investigate the effects of eating and emotions on reproductive axis function in patients with functional hypothalamic amenorrhea (FHA).Methods: A retrospective cohort study was conducted to summarize the clinical and endocrine characteristics of 58 patients with FHA at initial diagnosi...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Journal of Psychosomatic Obstetrics and Gynecology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0167482X.2024.2375718 |
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| author | Ye Lu Yao Chen Yuting Zhao Yulu Wang Hang Chen Feifei Zhang Xin Li |
| author_facet | Ye Lu Yao Chen Yuting Zhao Yulu Wang Hang Chen Feifei Zhang Xin Li |
| author_sort | Ye Lu |
| collection | DOAJ |
| description | Objective: To investigate the effects of eating and emotions on reproductive axis function in patients with functional hypothalamic amenorrhea (FHA).Methods: A retrospective cohort study was conducted to summarize the clinical and endocrine characteristics of 58 patients with FHA at initial diagnosis and to follow up the recovery of ovulation and spontaneous menstruation in the patients to investigate these biochemical indicators and their effects on recovery outcomes.Results: Among patients with FHA, 13.8% (8/58) and 15.5% (9/58) had above moderately severe depressive and severe anxiety symptoms respectively, and 25.9% (15/58) were at high risk for eating disorders. 34.5% (20/58) were included assessed as having recovered. The non-recovered group had higher scores on the Patient Health Questionnaire (PHQ-9) (p = .022) and higher scores on the Eating Attitude Test-26 (EAT-26) (p = .03) as well as bulimia and food preoccupation (p = .041). Follicle diameter >5 mm at initial diagnosis was an independent factor influencing recovery of reproductive axis function (odds ratio = 7.532; 95% confidence interval, 1.321–42.930; p = .023).Conculsions: Mood disorders and a certain risk of eating disorders were present in FHA. These, together with weight loss, endocrine and follicle size, could influence the outcome. |
| format | Article |
| id | doaj-art-fee61c1043fb4e7680a0788c0ad28f1d |
| institution | OA Journals |
| issn | 0167-482X 1743-8942 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Psychosomatic Obstetrics and Gynecology |
| spelling | doaj-art-fee61c1043fb4e7680a0788c0ad28f1d2025-08-20T02:01:25ZengTaylor & Francis GroupJournal of Psychosomatic Obstetrics and Gynecology0167-482X1743-89422024-12-0145110.1080/0167482X.2024.2375718Analysis of the effects of eating and emotions on reproductive axis function in patients with functional hypothalamic amenorrheaYe Lu0Yao Chen1Yuting Zhao2Yulu Wang3Hang Chen4Feifei Zhang5Xin Li6Department of Reproductive Endocrinology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, ChinaDepartment of Endocrinology and Metabolism, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Reproductive Endocrinology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, ChinaDepartment of Reproductive Endocrinology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, ChinaDepartment of Reproductive Endocrinology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, ChinaDepartment of Reproductive Endocrinology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, ChinaDepartment of Reproductive Endocrinology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, ChinaObjective: To investigate the effects of eating and emotions on reproductive axis function in patients with functional hypothalamic amenorrhea (FHA).Methods: A retrospective cohort study was conducted to summarize the clinical and endocrine characteristics of 58 patients with FHA at initial diagnosis and to follow up the recovery of ovulation and spontaneous menstruation in the patients to investigate these biochemical indicators and their effects on recovery outcomes.Results: Among patients with FHA, 13.8% (8/58) and 15.5% (9/58) had above moderately severe depressive and severe anxiety symptoms respectively, and 25.9% (15/58) were at high risk for eating disorders. 34.5% (20/58) were included assessed as having recovered. The non-recovered group had higher scores on the Patient Health Questionnaire (PHQ-9) (p = .022) and higher scores on the Eating Attitude Test-26 (EAT-26) (p = .03) as well as bulimia and food preoccupation (p = .041). Follicle diameter >5 mm at initial diagnosis was an independent factor influencing recovery of reproductive axis function (odds ratio = 7.532; 95% confidence interval, 1.321–42.930; p = .023).Conculsions: Mood disorders and a certain risk of eating disorders were present in FHA. These, together with weight loss, endocrine and follicle size, could influence the outcome.https://www.tandfonline.com/doi/10.1080/0167482X.2024.2375718Functional hypothalamic amenorrheaeating disorderdepressionanxietyhypothalamic-pituitary-ovary axis |
| spellingShingle | Ye Lu Yao Chen Yuting Zhao Yulu Wang Hang Chen Feifei Zhang Xin Li Analysis of the effects of eating and emotions on reproductive axis function in patients with functional hypothalamic amenorrhea Journal of Psychosomatic Obstetrics and Gynecology Functional hypothalamic amenorrhea eating disorder depression anxiety hypothalamic-pituitary-ovary axis |
| title | Analysis of the effects of eating and emotions on reproductive axis function in patients with functional hypothalamic amenorrhea |
| title_full | Analysis of the effects of eating and emotions on reproductive axis function in patients with functional hypothalamic amenorrhea |
| title_fullStr | Analysis of the effects of eating and emotions on reproductive axis function in patients with functional hypothalamic amenorrhea |
| title_full_unstemmed | Analysis of the effects of eating and emotions on reproductive axis function in patients with functional hypothalamic amenorrhea |
| title_short | Analysis of the effects of eating and emotions on reproductive axis function in patients with functional hypothalamic amenorrhea |
| title_sort | analysis of the effects of eating and emotions on reproductive axis function in patients with functional hypothalamic amenorrhea |
| topic | Functional hypothalamic amenorrhea eating disorder depression anxiety hypothalamic-pituitary-ovary axis |
| url | https://www.tandfonline.com/doi/10.1080/0167482X.2024.2375718 |
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