Molecular genetic aspects of intrahepatic cholangiocarcinoma: literature review
The modern concept of therapy for intrahepatic cholangiocarcinoma including surgical treatment, must take into account the achievements of molecular biology and modern staging principles. A detailed understanding of the molecular genetic (genetic and epigenetic) disorders underlying the pathogenesis...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2019-04-01
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| Series: | Успехи молекулярной онкологии |
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| Online Access: | https://umo.abvpress.ru/jour/article/view/204 |
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| author | B. N. Gurmikov Yu. A. Kovalenko V. A. Vishnevsky A. V. Chzhao |
| author_facet | B. N. Gurmikov Yu. A. Kovalenko V. A. Vishnevsky A. V. Chzhao |
| author_sort | B. N. Gurmikov |
| collection | DOAJ |
| description | The modern concept of therapy for intrahepatic cholangiocarcinoma including surgical treatment, must take into account the achievements of molecular biology and modern staging principles. A detailed understanding of the molecular genetic (genetic and epigenetic) disorders underlying the pathogenesis of cholangiocarcinoma is important, which will improve the results of surgical treatment and expand the possibilities of personalized (targeted) therapy. Based on new data on cholangiocarcinogenesis, molecular profiling of bile duct tumors may be most appropriate for the selection of treatment in cases refractory to standard therapy. Current potential target therapy targets include endothelial growth factor receptors, fibroblast growth factor, MET tyrosine kinase, PI3K/Akt/mTOR signaling pathway and isocitrate dehydrogenase mutation. The review considers the molecular-genetic aspects underlying the pathogenesis and modern principles of staging intrahepatic cholangiocarcinoma. |
| format | Article |
| id | doaj-art-fee5611fca144098aebeaf63efff1259 |
| institution | Kabale University |
| issn | 2313-805X 2413-3787 |
| language | Russian |
| publishDate | 2019-04-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Успехи молекулярной онкологии |
| spelling | doaj-art-fee5611fca144098aebeaf63efff12592025-08-20T03:37:43ZrusABV-pressУспехи молекулярной онкологии2313-805X2413-37872019-04-0161374310.17650/2313-805X-2019-6-1-37-43153Molecular genetic aspects of intrahepatic cholangiocarcinoma: literature reviewB. N. Gurmikov0Yu. A. Kovalenko1V. A. Vishnevsky2A. V. Chzhao3A.V. Vishnevsky National Medical Research Center of Surgery, Ministry of Health of RussiaA.V. Vishnevsky National Medical Research Center of Surgery, Ministry of Health of RussiaA.V. Vishnevsky National Medical Research Center of Surgery, Ministry of Health of RussiaA.V. Vishnevsky National Medical Research Center of Surgery, Ministry of Health of RussiaThe modern concept of therapy for intrahepatic cholangiocarcinoma including surgical treatment, must take into account the achievements of molecular biology and modern staging principles. A detailed understanding of the molecular genetic (genetic and epigenetic) disorders underlying the pathogenesis of cholangiocarcinoma is important, which will improve the results of surgical treatment and expand the possibilities of personalized (targeted) therapy. Based on new data on cholangiocarcinogenesis, molecular profiling of bile duct tumors may be most appropriate for the selection of treatment in cases refractory to standard therapy. Current potential target therapy targets include endothelial growth factor receptors, fibroblast growth factor, MET tyrosine kinase, PI3K/Akt/mTOR signaling pathway and isocitrate dehydrogenase mutation. The review considers the molecular-genetic aspects underlying the pathogenesis and modern principles of staging intrahepatic cholangiocarcinoma.https://umo.abvpress.ru/jour/article/view/204intrahepatic cholangiocarcinomamolecular genetic aspectstargeted therapystaging |
| spellingShingle | B. N. Gurmikov Yu. A. Kovalenko V. A. Vishnevsky A. V. Chzhao Molecular genetic aspects of intrahepatic cholangiocarcinoma: literature review Успехи молекулярной онкологии intrahepatic cholangiocarcinoma molecular genetic aspects targeted therapy staging |
| title | Molecular genetic aspects of intrahepatic cholangiocarcinoma: literature review |
| title_full | Molecular genetic aspects of intrahepatic cholangiocarcinoma: literature review |
| title_fullStr | Molecular genetic aspects of intrahepatic cholangiocarcinoma: literature review |
| title_full_unstemmed | Molecular genetic aspects of intrahepatic cholangiocarcinoma: literature review |
| title_short | Molecular genetic aspects of intrahepatic cholangiocarcinoma: literature review |
| title_sort | molecular genetic aspects of intrahepatic cholangiocarcinoma literature review |
| topic | intrahepatic cholangiocarcinoma molecular genetic aspects targeted therapy staging |
| url | https://umo.abvpress.ru/jour/article/view/204 |
| work_keys_str_mv | AT bngurmikov moleculargeneticaspectsofintrahepaticcholangiocarcinomaliteraturereview AT yuakovalenko moleculargeneticaspectsofintrahepaticcholangiocarcinomaliteraturereview AT vavishnevsky moleculargeneticaspectsofintrahepaticcholangiocarcinomaliteraturereview AT avchzhao moleculargeneticaspectsofintrahepaticcholangiocarcinomaliteraturereview |