The Prognostic Role of Naples Prognostic Score in Patients with Coronary Artery Disease
Yan Jiang,1 Yaqin Chen,1 Wen Lu,1 Yanchun Peng,2 Liangwan Chen,3,4 Yanjuan Lin2,3 1School of Nursing, Fujian Medical University, Fuzhou, Fujian, People’s Republic of China; 2Department of Nursing, Fujian Medical University Union Hospital, Fuzhou, Fujian, People’s Republic of China; 3Department of Ca...
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Dove Medical Press
2025-05-01
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| author | Jiang Y Chen Y Lu W Peng Y Chen L Lin Y |
| author_facet | Jiang Y Chen Y Lu W Peng Y Chen L Lin Y |
| author_sort | Jiang Y |
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| description | Yan Jiang,1 Yaqin Chen,1 Wen Lu,1 Yanchun Peng,2 Liangwan Chen,3,4 Yanjuan Lin2,3 1School of Nursing, Fujian Medical University, Fuzhou, Fujian, People’s Republic of China; 2Department of Nursing, Fujian Medical University Union Hospital, Fuzhou, Fujian, People’s Republic of China; 3Department of Cardiovascular Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian, People’s Republic of China; 4Fujian Provincial Special Reserve Talents Laboratory, Fuzhou, Fujian, People’s Republic of ChinaCorrespondence: Liangwan Chen, Department of Cardiovascular Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian, People’s Republic of China, Email fjxhlwc@163.com Yanjuan Lin, Department of Nursing, Fujian Medical University Union Hospital, Fuzhou, Fujian, People’s Republic of China, Email fjxhyjl@163.comBackground and Objective: The Naples Prognostic Score (NPS) is a tool for assessing inflammation and nutrition, widely used in outcome evaluation. However, its association with adverse outcomes in patients with coronary artery disease (CAD) has not been explored. This study aims to investigate the prognostic value of NPS in CAD patients.Methods: This retrospective cohort study included 2453 patients with CAD who visited the Fujian Heart Medical Center between 2017 and 2022. Patients were divided into three groups based on NPS. The NPS was calculated based on serum albumin, total cholesterol, neutrophil-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio. Univariate and multivariate regression analyses, along with Cox models, were used to assess the impact of NPS on adverse outcomes. Receiver operating characteristic (ROC) curves evaluated NPS’s accuracy in predicting all-cause in-hospital mortality.Results: Patients with lower NPS scores are less likely to have comorbidities such as hyperlipidemia and chronic kidney disease. Additionally, they tend to use fewer medications for treatment. Multivariate analysis revealed that elevated NPS levels were independently associated with poorer clinical outcomes. Compared to group 1, the risk of all-cause mortality was significantly higher in groups 2 and 3 [group 2, adjusted odds ratio (aOR)=0.33; group 3, aOR=1.82; P=0.037], the risk of acute myocardial infarction was higher (group 2, aOR=2.41; group 3, aOR=4.05; P< 0.001), and the risk of stroke was also higher (group 2, aOR=1.26; group 3, aOR=1.80; P=0.039). ROC curve analysis showed that NPS could independently predict the risk of all-cause mortality in patients with CAD.Conclusion: This study suggests that the NPS, a novel metric integrating inflammation and nutritional status, is closely associated with the prognosis of CAD.Keywords: naples prognostic score, outcomes, coronary artery disease, prognosis |
| format | Article |
| id | doaj-art-fee33dfdeeab4859b0a4416db141fd46 |
| institution | Kabale University |
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| language | English |
| publishDate | 2025-05-01 |
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| spelling | doaj-art-fee33dfdeeab4859b0a4416db141fd462025-08-20T03:29:49ZengDove Medical PressJournal of Inflammation Research1178-70312025-05-01Volume 18Issue 169997012103429The Prognostic Role of Naples Prognostic Score in Patients with Coronary Artery DiseaseJiang Y0Chen Y1Lu W2Peng Y3Chen L4Lin Y5School of NursingSchool of NursingSchool of NursingDepartment of NursingDepartment of Cardiovascular SurgeryDepartment of NursingYan Jiang,1 Yaqin Chen,1 Wen Lu,1 Yanchun Peng,2 Liangwan Chen,3,4 Yanjuan Lin2,3 1School of Nursing, Fujian Medical University, Fuzhou, Fujian, People’s Republic of China; 2Department of Nursing, Fujian Medical University Union Hospital, Fuzhou, Fujian, People’s Republic of China; 3Department of Cardiovascular Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian, People’s Republic of China; 4Fujian Provincial Special Reserve Talents Laboratory, Fuzhou, Fujian, People’s Republic of ChinaCorrespondence: Liangwan Chen, Department of Cardiovascular Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian, People’s Republic of China, Email fjxhlwc@163.com Yanjuan Lin, Department of Nursing, Fujian Medical University Union Hospital, Fuzhou, Fujian, People’s Republic of China, Email fjxhyjl@163.comBackground and Objective: The Naples Prognostic Score (NPS) is a tool for assessing inflammation and nutrition, widely used in outcome evaluation. However, its association with adverse outcomes in patients with coronary artery disease (CAD) has not been explored. This study aims to investigate the prognostic value of NPS in CAD patients.Methods: This retrospective cohort study included 2453 patients with CAD who visited the Fujian Heart Medical Center between 2017 and 2022. Patients were divided into three groups based on NPS. The NPS was calculated based on serum albumin, total cholesterol, neutrophil-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio. Univariate and multivariate regression analyses, along with Cox models, were used to assess the impact of NPS on adverse outcomes. Receiver operating characteristic (ROC) curves evaluated NPS’s accuracy in predicting all-cause in-hospital mortality.Results: Patients with lower NPS scores are less likely to have comorbidities such as hyperlipidemia and chronic kidney disease. Additionally, they tend to use fewer medications for treatment. Multivariate analysis revealed that elevated NPS levels were independently associated with poorer clinical outcomes. Compared to group 1, the risk of all-cause mortality was significantly higher in groups 2 and 3 [group 2, adjusted odds ratio (aOR)=0.33; group 3, aOR=1.82; P=0.037], the risk of acute myocardial infarction was higher (group 2, aOR=2.41; group 3, aOR=4.05; P< 0.001), and the risk of stroke was also higher (group 2, aOR=1.26; group 3, aOR=1.80; P=0.039). ROC curve analysis showed that NPS could independently predict the risk of all-cause mortality in patients with CAD.Conclusion: This study suggests that the NPS, a novel metric integrating inflammation and nutritional status, is closely associated with the prognosis of CAD.Keywords: naples prognostic score, outcomes, coronary artery disease, prognosishttps://www.dovepress.com/the-prognostic-role-of-naples-prognostic-score-in-patients-with-corona-peer-reviewed-fulltext-article-JIRNaples prognostic scoreoutcomescoronary artery diseaseprognosis |
| spellingShingle | Jiang Y Chen Y Lu W Peng Y Chen L Lin Y The Prognostic Role of Naples Prognostic Score in Patients with Coronary Artery Disease Journal of Inflammation Research Naples prognostic score outcomes coronary artery disease prognosis |
| title | The Prognostic Role of Naples Prognostic Score in Patients with Coronary Artery Disease |
| title_full | The Prognostic Role of Naples Prognostic Score in Patients with Coronary Artery Disease |
| title_fullStr | The Prognostic Role of Naples Prognostic Score in Patients with Coronary Artery Disease |
| title_full_unstemmed | The Prognostic Role of Naples Prognostic Score in Patients with Coronary Artery Disease |
| title_short | The Prognostic Role of Naples Prognostic Score in Patients with Coronary Artery Disease |
| title_sort | prognostic role of naples prognostic score in patients with coronary artery disease |
| topic | Naples prognostic score outcomes coronary artery disease prognosis |
| url | https://www.dovepress.com/the-prognostic-role-of-naples-prognostic-score-in-patients-with-corona-peer-reviewed-fulltext-article-JIR |
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