Waldenström Macroglobulinemia Diagnosed by Ultrasonography‐Guided Biopsy of the Right Perinephric Tumor

ABSTRACT Introduction Waldenström macroglobulinemia is a low‐grade B‐cell lymphoma characterized by lymphoplasmacytic lymphoma infiltration of the bone marrow and immunoglobulin M (IgM) protein. Case Presentation An 80s‐year‐old male presented to our hospital with chief complaints of weight loss and...

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Main Authors: Shingo Morinaga, Shigeyuki Aoki, Motoi Tobiume, Genya Nishikawa, Fusako Higuchi, Yuusuke Ikenohata, Manabu Honda, Hiroe Kubo, Tomoko Sawada, Yoshiaki Yamada
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:IJU Case Reports
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Online Access:https://doi.org/10.1002/iju5.70022
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author Shingo Morinaga
Shigeyuki Aoki
Motoi Tobiume
Genya Nishikawa
Fusako Higuchi
Yuusuke Ikenohata
Manabu Honda
Hiroe Kubo
Tomoko Sawada
Yoshiaki Yamada
author_facet Shingo Morinaga
Shigeyuki Aoki
Motoi Tobiume
Genya Nishikawa
Fusako Higuchi
Yuusuke Ikenohata
Manabu Honda
Hiroe Kubo
Tomoko Sawada
Yoshiaki Yamada
author_sort Shingo Morinaga
collection DOAJ
description ABSTRACT Introduction Waldenström macroglobulinemia is a low‐grade B‐cell lymphoma characterized by lymphoplasmacytic lymphoma infiltration of the bone marrow and immunoglobulin M (IgM) protein. Case Presentation An 80s‐year‐old male presented to our hospital with chief complaints of weight loss and general fatigue. Computed tomography (CT) showed homogeneous tumor around the kidney with elevated soluble Interleukin‐2 receptor, serum IgM, and β2‐microglobulin levels. Histopathological analysis by ultrasonography‐guided biopsy revealed dense lymphocytic proliferation, plasmacytoid differentiation, and Dutcher bodies, positive for CD20, CD138, and IgM, but negative for CD3 and CD5, consistent with lymphoplasmacytic lymphoma. Bone marrow biopsy revealed infiltration of the lymphoplasmacytic lymphoma. The patient received four courses of bortezomib, cyclophosphamide, and dexamethasone along with dexamethasone, rituximab, and cyclophosphamide therapy. Twelve months after treatment, CT revealed only slightly enlarged abdominal para‐aortic lymph nodes. Conclusion Malignant lymphoma in perinephric lesions is a relatively rare condition; however, a definitive diagnosis can be obtained by ultrasound‐guided biopsy, allowing early initiation.
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spelling doaj-art-fecbe360f7fc4aa49e936fdf29f5ba4a2025-08-20T02:14:31ZengWileyIJU Case Reports2577-171X2025-05-018327127510.1002/iju5.70022Waldenström Macroglobulinemia Diagnosed by Ultrasonography‐Guided Biopsy of the Right Perinephric TumorShingo Morinaga0Shigeyuki Aoki1Motoi Tobiume2Genya Nishikawa3Fusako Higuchi4Yuusuke Ikenohata5Manabu Honda6Hiroe Kubo7Tomoko Sawada8Yoshiaki Yamada9Department of Urology Japan Community Health Care Organization Kani Tono Hospital Kani Gifu JapanDepartment of Urology Japan Community Health Care Organization Kani Tono Hospital Kani Gifu JapanDepartment of Urology Japan Organization of Occupational Health and Safety Asahi Rosai Hospital Owariasahi Aichi JapanDepartment of Urology Japan Organization of Occupational Health and Safety Asahi Rosai Hospital Owariasahi Aichi JapanDepartment of Clinical Laboratory Japan Community Health Care Organization Kani Tono Hospital Kani Gifu JapanDivision of Nursing Japan Community Health Care Organization Kani Tono Hospital Kani Gifu JapanDivision of Radiology Japan Community Health Care Organization Kani Tono Hospital Kani Gifu JapanDivision of Hospital and Clinic Coordination Japan Community Health Care Organization Kani Tono Hospital Kani Gifu JapanDivision of Hospital and Clinic Coordination Japan Community Health Care Organization Kani Tono Hospital Kani Gifu JapanDepartment of Urology Japan Community Health Care Organization Kani Tono Hospital Kani Gifu JapanABSTRACT Introduction Waldenström macroglobulinemia is a low‐grade B‐cell lymphoma characterized by lymphoplasmacytic lymphoma infiltration of the bone marrow and immunoglobulin M (IgM) protein. Case Presentation An 80s‐year‐old male presented to our hospital with chief complaints of weight loss and general fatigue. Computed tomography (CT) showed homogeneous tumor around the kidney with elevated soluble Interleukin‐2 receptor, serum IgM, and β2‐microglobulin levels. Histopathological analysis by ultrasonography‐guided biopsy revealed dense lymphocytic proliferation, plasmacytoid differentiation, and Dutcher bodies, positive for CD20, CD138, and IgM, but negative for CD3 and CD5, consistent with lymphoplasmacytic lymphoma. Bone marrow biopsy revealed infiltration of the lymphoplasmacytic lymphoma. The patient received four courses of bortezomib, cyclophosphamide, and dexamethasone along with dexamethasone, rituximab, and cyclophosphamide therapy. Twelve months after treatment, CT revealed only slightly enlarged abdominal para‐aortic lymph nodes. Conclusion Malignant lymphoma in perinephric lesions is a relatively rare condition; however, a definitive diagnosis can be obtained by ultrasound‐guided biopsy, allowing early initiation.https://doi.org/10.1002/iju5.70022lymphoplasmacytic lymphomamalignant lymphomaperinephric tumorultrasonography‐guided biopsyWaldenström macroglobulinemia
spellingShingle Shingo Morinaga
Shigeyuki Aoki
Motoi Tobiume
Genya Nishikawa
Fusako Higuchi
Yuusuke Ikenohata
Manabu Honda
Hiroe Kubo
Tomoko Sawada
Yoshiaki Yamada
Waldenström Macroglobulinemia Diagnosed by Ultrasonography‐Guided Biopsy of the Right Perinephric Tumor
IJU Case Reports
lymphoplasmacytic lymphoma
malignant lymphoma
perinephric tumor
ultrasonography‐guided biopsy
Waldenström macroglobulinemia
title Waldenström Macroglobulinemia Diagnosed by Ultrasonography‐Guided Biopsy of the Right Perinephric Tumor
title_full Waldenström Macroglobulinemia Diagnosed by Ultrasonography‐Guided Biopsy of the Right Perinephric Tumor
title_fullStr Waldenström Macroglobulinemia Diagnosed by Ultrasonography‐Guided Biopsy of the Right Perinephric Tumor
title_full_unstemmed Waldenström Macroglobulinemia Diagnosed by Ultrasonography‐Guided Biopsy of the Right Perinephric Tumor
title_short Waldenström Macroglobulinemia Diagnosed by Ultrasonography‐Guided Biopsy of the Right Perinephric Tumor
title_sort waldenstrom macroglobulinemia diagnosed by ultrasonography guided biopsy of the right perinephric tumor
topic lymphoplasmacytic lymphoma
malignant lymphoma
perinephric tumor
ultrasonography‐guided biopsy
Waldenström macroglobulinemia
url https://doi.org/10.1002/iju5.70022
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