A clinical case of successful treatment of the patient with brain metastases using photodynamic therapy and fluorescence diagnostics
Background. Cancer incidence is steadily increasing every year, and an estimated 20 % of cancer patients will develop brain metastases. This dictates the need to develop effective treatment modalities. Clinical case description. A 49-year-old female patient was admitted to the Russian Research Neuro...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Russian Academy of Sciences, Tomsk National Research Medical Center
2025-03-01
|
| Series: | Сибирский онкологический журнал |
| Subjects: | |
| Online Access: | https://www.siboncoj.ru/jour/article/view/3461 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850041255947403264 |
|---|---|
| author | S. S. Sklyar D. A. Sitovskaya A. Y. Ulitin K. I. Sebelev E. V. Andreev A. S. Nechaeva E. Y. Zorina A. M. Konova A. K. Baknina M. V. Dikonenko K. K. Kukanov A. E. Vershinin V. E. Olyushin |
| author_facet | S. S. Sklyar D. A. Sitovskaya A. Y. Ulitin K. I. Sebelev E. V. Andreev A. S. Nechaeva E. Y. Zorina A. M. Konova A. K. Baknina M. V. Dikonenko K. K. Kukanov A. E. Vershinin V. E. Olyushin |
| author_sort | S. S. Sklyar |
| collection | DOAJ |
| description | Background. Cancer incidence is steadily increasing every year, and an estimated 20 % of cancer patients will develop brain metastases. This dictates the need to develop effective treatment modalities. Clinical case description. A 49-year-old female patient was admitted to the Russian Research Neurosurgical Institute with stage IV cT1bN2M1 squamous cell carcinoma of the right lower-lobe bronchus (metastases in the brain) with a local recurrence of metastasis in the right temporal lobe. Removal of the tumor was performed under fluorescent guidance and biospectroscopy using a fiber-optic probe and uno software. Histopathological examination of the biopsy sample and IHC staining confirmed metastastatic squamous cell carcinoma. Photodynamic therapy (PDT) of the bed of the removed tumor was performed using the LFT-02-Biospect laser system (Biospec, Russia) with biospectroscopy. The therapy was completed upon achieving the photobleaching effect and reducing the fluorescence index to values close to normal tissues. The histological examination of the perifocal zone after PDT demonstrated the absence of tumor cells and the presence of pronounced lymphocyte infiltration, which may indicate activation of the immune system. evaluation of the perifocal zone after PDT by means of histological examination demonstrated the absence of tumor cells and the presence of pronounced lymphocyte infiltration, which may indirectly indicate activation of the local immune response. The patient was subsequently observed by an oncologist at her place of residence with follow-up examinations. Antitumor therapy was not prescribed. Conclusion. In this case, no disease recurrence during a follow-up of 11 months, as well as persistent stabilization of the primary tumor with regression of extracranial foci for 6 months was observed. PDT, a treatment method that selectively and locally destroys tumor cells, appears to be safe and promising especially for patients with brain metastases. |
| format | Article |
| id | doaj-art-feb4e5830f7641b78bbd60f0cf83b403 |
| institution | DOAJ |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| publishDate | 2025-03-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj-art-feb4e5830f7641b78bbd60f0cf83b4032025-08-20T02:55:49ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682025-03-0124117418810.21294/1814-4861-2025-24-1-174-1881321A clinical case of successful treatment of the patient with brain metastases using photodynamic therapy and fluorescence diagnosticsS. S. Sklyar0D. A. Sitovskaya1A. Y. Ulitin2K. I. Sebelev3E. V. Andreev4A. S. Nechaeva5E. Y. Zorina6A. M. Konova7A. K. Baknina8M. V. Dikonenko9K. K. Kukanov10A. E. Vershinin11V. E. Olyushin12Russian Neurosurgical Institute named after Professor A.L. Polenov – a branch of National Medical Research Center named after V.A. Almazov of the Ministry of Health of RussiaRussian Neurosurgical Institute named after Professor A.L. Polenov – a branch of National Medical Research Center named after V.A. Almazov of the Ministry of Health of RussiaRussian Neurosurgical Institute named after Professor A.L. Polenov – a branch of National Medical Research Center named after V.A. Almazov of the Ministry of Health of Russia; Institute of Medical Education, National Medical Research Center named after V.A. Almazov of the Ministry of Health of Russia; North-Western State Medical University named after I.I. Mechnikov of the Ministry of Health of RussiaRussian Neurosurgical Institute named after Professor A.L. Polenov – a branch of National Medical Research Center named after V.A. Almazov of the Ministry of Health of RussiaRussian Neurosurgical Institute named after Professor A.L. Polenov – a branch of National Medical Research Center named after V.A. Almazov of the Ministry of Health of RussiaRussian Neurosurgical Institute named after Professor A.L. Polenov – a branch of National Medical Research Center named after V.A. Almazov of the Ministry of Health of RussiaNational Medical Research Center named after V.A. Almazov of the Ministry of Health of RussiaNational Medical Research Center named after V.A. Almazov of the Ministry of Health of RussiaInstitute of Medical Education, National Medical Research Center named after V.A. Almazov of the Ministry of Health of RussiaRussian Neurosurgical Institute named after Professor A.L. Polenov – a branch of National Medical Research Center named after V.A. Almazov of the Ministry of Health of Russia; Institute of Medical Education, National Medical Research Center named after V.A. Almazov of the Ministry of Health of RussiaRussian Neurosurgical Institute named after Professor A.L. Polenov – a branch of National Medical Research Center named after V.A. Almazov of the Ministry of Health of RussiaInstitute of Medical Education, National Medical Research Center named after V.A. Almazov of the Ministry of Health of RussiaRussian Neurosurgical Institute named after Professor A.L. Polenov – a branch of National Medical Research Center named after V.A. Almazov of the Ministry of Health of RussiaBackground. Cancer incidence is steadily increasing every year, and an estimated 20 % of cancer patients will develop brain metastases. This dictates the need to develop effective treatment modalities. Clinical case description. A 49-year-old female patient was admitted to the Russian Research Neurosurgical Institute with stage IV cT1bN2M1 squamous cell carcinoma of the right lower-lobe bronchus (metastases in the brain) with a local recurrence of metastasis in the right temporal lobe. Removal of the tumor was performed under fluorescent guidance and biospectroscopy using a fiber-optic probe and uno software. Histopathological examination of the biopsy sample and IHC staining confirmed metastastatic squamous cell carcinoma. Photodynamic therapy (PDT) of the bed of the removed tumor was performed using the LFT-02-Biospect laser system (Biospec, Russia) with biospectroscopy. The therapy was completed upon achieving the photobleaching effect and reducing the fluorescence index to values close to normal tissues. The histological examination of the perifocal zone after PDT demonstrated the absence of tumor cells and the presence of pronounced lymphocyte infiltration, which may indicate activation of the immune system. evaluation of the perifocal zone after PDT by means of histological examination demonstrated the absence of tumor cells and the presence of pronounced lymphocyte infiltration, which may indirectly indicate activation of the local immune response. The patient was subsequently observed by an oncologist at her place of residence with follow-up examinations. Antitumor therapy was not prescribed. Conclusion. In this case, no disease recurrence during a follow-up of 11 months, as well as persistent stabilization of the primary tumor with regression of extracranial foci for 6 months was observed. PDT, a treatment method that selectively and locally destroys tumor cells, appears to be safe and promising especially for patients with brain metastases.https://www.siboncoj.ru/jour/article/view/3461cerebral metastasissecondary brain damagephotodynamic therapyfluorescence diagnosticsbiospectroscopychemotherapylung cancer |
| spellingShingle | S. S. Sklyar D. A. Sitovskaya A. Y. Ulitin K. I. Sebelev E. V. Andreev A. S. Nechaeva E. Y. Zorina A. M. Konova A. K. Baknina M. V. Dikonenko K. K. Kukanov A. E. Vershinin V. E. Olyushin A clinical case of successful treatment of the patient with brain metastases using photodynamic therapy and fluorescence diagnostics Сибирский онкологический журнал cerebral metastasis secondary brain damage photodynamic therapy fluorescence diagnostics biospectroscopy chemotherapy lung cancer |
| title | A clinical case of successful treatment of the patient with brain metastases using photodynamic therapy and fluorescence diagnostics |
| title_full | A clinical case of successful treatment of the patient with brain metastases using photodynamic therapy and fluorescence diagnostics |
| title_fullStr | A clinical case of successful treatment of the patient with brain metastases using photodynamic therapy and fluorescence diagnostics |
| title_full_unstemmed | A clinical case of successful treatment of the patient with brain metastases using photodynamic therapy and fluorescence diagnostics |
| title_short | A clinical case of successful treatment of the patient with brain metastases using photodynamic therapy and fluorescence diagnostics |
| title_sort | clinical case of successful treatment of the patient with brain metastases using photodynamic therapy and fluorescence diagnostics |
| topic | cerebral metastasis secondary brain damage photodynamic therapy fluorescence diagnostics biospectroscopy chemotherapy lung cancer |
| url | https://www.siboncoj.ru/jour/article/view/3461 |
| work_keys_str_mv | AT sssklyar aclinicalcaseofsuccessfultreatmentofthepatientwithbrainmetastasesusingphotodynamictherapyandfluorescencediagnostics AT dasitovskaya aclinicalcaseofsuccessfultreatmentofthepatientwithbrainmetastasesusingphotodynamictherapyandfluorescencediagnostics AT ayulitin aclinicalcaseofsuccessfultreatmentofthepatientwithbrainmetastasesusingphotodynamictherapyandfluorescencediagnostics AT kisebelev aclinicalcaseofsuccessfultreatmentofthepatientwithbrainmetastasesusingphotodynamictherapyandfluorescencediagnostics AT evandreev aclinicalcaseofsuccessfultreatmentofthepatientwithbrainmetastasesusingphotodynamictherapyandfluorescencediagnostics AT asnechaeva aclinicalcaseofsuccessfultreatmentofthepatientwithbrainmetastasesusingphotodynamictherapyandfluorescencediagnostics AT eyzorina aclinicalcaseofsuccessfultreatmentofthepatientwithbrainmetastasesusingphotodynamictherapyandfluorescencediagnostics AT amkonova aclinicalcaseofsuccessfultreatmentofthepatientwithbrainmetastasesusingphotodynamictherapyandfluorescencediagnostics AT akbaknina aclinicalcaseofsuccessfultreatmentofthepatientwithbrainmetastasesusingphotodynamictherapyandfluorescencediagnostics AT mvdikonenko aclinicalcaseofsuccessfultreatmentofthepatientwithbrainmetastasesusingphotodynamictherapyandfluorescencediagnostics AT kkkukanov aclinicalcaseofsuccessfultreatmentofthepatientwithbrainmetastasesusingphotodynamictherapyandfluorescencediagnostics AT aevershinin aclinicalcaseofsuccessfultreatmentofthepatientwithbrainmetastasesusingphotodynamictherapyandfluorescencediagnostics AT veolyushin aclinicalcaseofsuccessfultreatmentofthepatientwithbrainmetastasesusingphotodynamictherapyandfluorescencediagnostics AT sssklyar clinicalcaseofsuccessfultreatmentofthepatientwithbrainmetastasesusingphotodynamictherapyandfluorescencediagnostics AT dasitovskaya clinicalcaseofsuccessfultreatmentofthepatientwithbrainmetastasesusingphotodynamictherapyandfluorescencediagnostics AT ayulitin clinicalcaseofsuccessfultreatmentofthepatientwithbrainmetastasesusingphotodynamictherapyandfluorescencediagnostics AT kisebelev clinicalcaseofsuccessfultreatmentofthepatientwithbrainmetastasesusingphotodynamictherapyandfluorescencediagnostics AT evandreev clinicalcaseofsuccessfultreatmentofthepatientwithbrainmetastasesusingphotodynamictherapyandfluorescencediagnostics AT asnechaeva clinicalcaseofsuccessfultreatmentofthepatientwithbrainmetastasesusingphotodynamictherapyandfluorescencediagnostics AT eyzorina clinicalcaseofsuccessfultreatmentofthepatientwithbrainmetastasesusingphotodynamictherapyandfluorescencediagnostics AT amkonova clinicalcaseofsuccessfultreatmentofthepatientwithbrainmetastasesusingphotodynamictherapyandfluorescencediagnostics AT akbaknina clinicalcaseofsuccessfultreatmentofthepatientwithbrainmetastasesusingphotodynamictherapyandfluorescencediagnostics AT mvdikonenko clinicalcaseofsuccessfultreatmentofthepatientwithbrainmetastasesusingphotodynamictherapyandfluorescencediagnostics AT kkkukanov clinicalcaseofsuccessfultreatmentofthepatientwithbrainmetastasesusingphotodynamictherapyandfluorescencediagnostics AT aevershinin clinicalcaseofsuccessfultreatmentofthepatientwithbrainmetastasesusingphotodynamictherapyandfluorescencediagnostics AT veolyushin clinicalcaseofsuccessfultreatmentofthepatientwithbrainmetastasesusingphotodynamictherapyandfluorescencediagnostics |