Effects of Vitamin D Supplementation on Blood Pressure in Patients With Type 1 Diabetes Mellitus: A Systematic Review of Clinical Trials
ABSTRACT Background and Aims Hypertension exacerbates cardiovascular risks in patients with type 1 diabetes mellitus (T1DM), necessitating effective blood pressure (BP) management. Vitamin D deficiency is common in T1DM patients and is associated with an increased risk of cardiovascular diseases. Th...
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Wiley
2025-03-01
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| Online Access: | https://doi.org/10.1002/hsr2.70524 |
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| author | Rasoul Ebrahimi Mohammad Mahdi Masouri Amir Abbas Salehi Amniyeh Khozani Sana Mohammad Soltani Seyed Aria Nejadghaderi |
| author_facet | Rasoul Ebrahimi Mohammad Mahdi Masouri Amir Abbas Salehi Amniyeh Khozani Sana Mohammad Soltani Seyed Aria Nejadghaderi |
| author_sort | Rasoul Ebrahimi |
| collection | DOAJ |
| description | ABSTRACT Background and Aims Hypertension exacerbates cardiovascular risks in patients with type 1 diabetes mellitus (T1DM), necessitating effective blood pressure (BP) management. Vitamin D deficiency is common in T1DM patients and is associated with an increased risk of cardiovascular diseases. This systematic review aimed to evaluate the impact of vitamin D supplementation on BP in T1DM patients. Methods PubMed, Web of Science, Embase, Scopus, and Google Scholar were searched until March 2024. Clinical trials reported BP outcomes in patients with T1DM after vitamin D supplementation were included. Other types of studies and studies that did not report BP outcomes and those that had populations other than patients with T1DM were excluded. The National Institutes of Health (NIH) tool was used for the risk of bias assessment. Results In total, eight studies, involving 328 participants, were included in this review. They were conducted between 2014 and 2024, with mostly conducted in Brazil (n = 5). While one study demonstrated a significant reduction in morning systolic and diastolic BP after vitamin D supplementation, five studies found no significant differences in systolic or diastolic BP. Another study noted a significant reduction in morning systolic and diastolic BP, with no significant changes in 24‐h ambulatory monitoring. Also, paricalcitol therapy did not significantly reduce systolic and diastolic ambulatory BP compared to placebo. Conclusion The current evidence on the effect of vitamin D supplementation on blood pressure in patients with T1DM remains inconclusive. Nonetheless, more randomized controlled studies with larger sample sizes and longer follow‐up durations are essential to establish the association between vitamin D and BP in this population. |
| format | Article |
| id | doaj-art-feadff7df95f41f6b4881b73ce6f181d |
| institution | OA Journals |
| issn | 2398-8835 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Health Science Reports |
| spelling | doaj-art-feadff7df95f41f6b4881b73ce6f181d2025-08-20T01:50:26ZengWileyHealth Science Reports2398-88352025-03-0183n/an/a10.1002/hsr2.70524Effects of Vitamin D Supplementation on Blood Pressure in Patients With Type 1 Diabetes Mellitus: A Systematic Review of Clinical TrialsRasoul Ebrahimi0Mohammad Mahdi Masouri1Amir Abbas Salehi Amniyeh Khozani2Sana Mohammad Soltani3Seyed Aria Nejadghaderi4School of Medicine Shahid Beheshti University of Medical Sciences Tehran IranSchool of Medicine Shahid Beheshti University of Medical Sciences Tehran IranSchool of Medicine Shahid Beheshti University of Medical Sciences Tehran IranSchool of Medicine Shahid Beheshti University of Medical Sciences Tehran IranHIV/STI Surveillance Research Center, and WHO Collaborating Center for HIV Surveillance, Institute for Futures Studies in Health Kerman University of Medical Sciences Kerman IranABSTRACT Background and Aims Hypertension exacerbates cardiovascular risks in patients with type 1 diabetes mellitus (T1DM), necessitating effective blood pressure (BP) management. Vitamin D deficiency is common in T1DM patients and is associated with an increased risk of cardiovascular diseases. This systematic review aimed to evaluate the impact of vitamin D supplementation on BP in T1DM patients. Methods PubMed, Web of Science, Embase, Scopus, and Google Scholar were searched until March 2024. Clinical trials reported BP outcomes in patients with T1DM after vitamin D supplementation were included. Other types of studies and studies that did not report BP outcomes and those that had populations other than patients with T1DM were excluded. The National Institutes of Health (NIH) tool was used for the risk of bias assessment. Results In total, eight studies, involving 328 participants, were included in this review. They were conducted between 2014 and 2024, with mostly conducted in Brazil (n = 5). While one study demonstrated a significant reduction in morning systolic and diastolic BP after vitamin D supplementation, five studies found no significant differences in systolic or diastolic BP. Another study noted a significant reduction in morning systolic and diastolic BP, with no significant changes in 24‐h ambulatory monitoring. Also, paricalcitol therapy did not significantly reduce systolic and diastolic ambulatory BP compared to placebo. Conclusion The current evidence on the effect of vitamin D supplementation on blood pressure in patients with T1DM remains inconclusive. Nonetheless, more randomized controlled studies with larger sample sizes and longer follow‐up durations are essential to establish the association between vitamin D and BP in this population.https://doi.org/10.1002/hsr2.70524blood pressurediabetes mellitushypertensionsystematic reviewtype 1vitamin D |
| spellingShingle | Rasoul Ebrahimi Mohammad Mahdi Masouri Amir Abbas Salehi Amniyeh Khozani Sana Mohammad Soltani Seyed Aria Nejadghaderi Effects of Vitamin D Supplementation on Blood Pressure in Patients With Type 1 Diabetes Mellitus: A Systematic Review of Clinical Trials Health Science Reports blood pressure diabetes mellitus hypertension systematic review type 1 vitamin D |
| title | Effects of Vitamin D Supplementation on Blood Pressure in Patients With Type 1 Diabetes Mellitus: A Systematic Review of Clinical Trials |
| title_full | Effects of Vitamin D Supplementation on Blood Pressure in Patients With Type 1 Diabetes Mellitus: A Systematic Review of Clinical Trials |
| title_fullStr | Effects of Vitamin D Supplementation on Blood Pressure in Patients With Type 1 Diabetes Mellitus: A Systematic Review of Clinical Trials |
| title_full_unstemmed | Effects of Vitamin D Supplementation on Blood Pressure in Patients With Type 1 Diabetes Mellitus: A Systematic Review of Clinical Trials |
| title_short | Effects of Vitamin D Supplementation on Blood Pressure in Patients With Type 1 Diabetes Mellitus: A Systematic Review of Clinical Trials |
| title_sort | effects of vitamin d supplementation on blood pressure in patients with type 1 diabetes mellitus a systematic review of clinical trials |
| topic | blood pressure diabetes mellitus hypertension systematic review type 1 vitamin D |
| url | https://doi.org/10.1002/hsr2.70524 |
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