Human CD33 deficiency is associated with mild alteration of circulating white blood cell counts.

Human CD33 deficiency is associated with mild alteration of circulating white blood cell counts.

The single pass transmembrane protein CD33 is enriched in phagocytic and hematopoietic cell types, such as monocytes. CD33 is thought to be associated with immune cell function, susceptibility to Alzheimer's disease, and rare leukemias. Antagonism or genetic ablation of CD33 has been proposed t...

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Main Authors: John Dominy, Jirong Bai, Christopher Koch, Maleeha Zaman Khan, Shareef Khalid, Jonathan H Chung, Madhura Panditrao, Lulu Liu, Qi Zhang, Muhammad Jahanzaib, Muhammad Rehan Mian, Muhammad Bilal Liaqat, Syed Shahzaib Raza, Riffat Sultana, Anjum Jalal, Muhammad Hamid Saeed, Shahid Abbas, Fazal Rehman Memon, Mohammad Ishaq, Kashif Saleheen, Asif Rasheed, Allan Gurtan, Danish Saleheen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-03-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1011600
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