Influence of Obesity Parameters on Different Regional Patterns of Lymph Node Metastasis in Papillary Thyroid Cancer
Objective. Obesity increases risk of thyroid cancer. However, the association between obesity and the progression of papillary thyroid cancer (PTC) remains controversial. This retrospective study aimed to explore the relationship between obesity and regional patterns of lymph node metastasis (LNM) i...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2022/3797955 |
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| author | Wan-Xiao Wu Jia-Wei Feng Jing Ye Gao-Feng Qi Li-Zhao Hong Jun Hu Sheng-Yong Liu Yong Jiang Zhen Qu |
| author_facet | Wan-Xiao Wu Jia-Wei Feng Jing Ye Gao-Feng Qi Li-Zhao Hong Jun Hu Sheng-Yong Liu Yong Jiang Zhen Qu |
| author_sort | Wan-Xiao Wu |
| collection | DOAJ |
| description | Objective. Obesity increases risk of thyroid cancer. However, the association between obesity and the progression of papillary thyroid cancer (PTC) remains controversial. This retrospective study aimed to explore the relationship between obesity and regional patterns of lymph node metastasis (LNM) in PTC. Methods. We retrospectively reviewed data from 1015 patients with PTC. We calculated obese parameters, such as body mass index (BMI), body fat percentage (BFP), and body surface area (BSA). Logistic regression models were used to assess associations between obese parameters and the rate of lymph node metastasis (LNM), number of LNM, pattern of LNM, and lymph node ratio (LNR). Results. Higher BMI was not associated with different regional patterns of LNM in PTC. In men with PTC, high BFP was an independent predictor of total LNM, central lymph node metastasis (CLNM), total lateral lymph node metastasis (LLNM), multiple lateral lymph node metastasis, and simultaneous metastasis in lateral compartment. In addition, male patients with high BFP had higher central LNR and higher number of CLNM. For women, high BSA was an independent predictor of LLNM and level IV metastasis. Female patients with high BSA had higher number of CLNM. Conclusion. BFP and BSA, possibly influenced by gender, were positively associated with the number and risk of LNM in different regions of PTC patients. However, BMI was not the predictor for aggressiveness of PTC in terms of LNM. Clinical decision-making for regional LNM in PTC patients should consider the factor of obesity. |
| format | Article |
| id | doaj-art-fea7538219724e2a8912d63a39d152e4 |
| institution | Kabale University |
| issn | 1687-8345 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-fea7538219724e2a8912d63a39d152e42025-02-03T06:13:33ZengWileyInternational Journal of Endocrinology1687-83452022-01-01202210.1155/2022/3797955Influence of Obesity Parameters on Different Regional Patterns of Lymph Node Metastasis in Papillary Thyroid CancerWan-Xiao Wu0Jia-Wei Feng1Jing Ye2Gao-Feng Qi3Li-Zhao Hong4Jun Hu5Sheng-Yong Liu6Yong Jiang7Zhen Qu8The Third Affiliated Hospital of Soochow UniversityThe Third Affiliated Hospital of Soochow UniversityThe Third Affiliated Hospital of Soochow UniversityThe Third Affiliated Hospital of Soochow UniversityThe Third Affiliated Hospital of Soochow UniversityThe Third Affiliated Hospital of Soochow UniversityThe Third Affiliated Hospital of Soochow UniversityThe Third Affiliated Hospital of Soochow UniversityThe Third Affiliated Hospital of Soochow UniversityObjective. Obesity increases risk of thyroid cancer. However, the association between obesity and the progression of papillary thyroid cancer (PTC) remains controversial. This retrospective study aimed to explore the relationship between obesity and regional patterns of lymph node metastasis (LNM) in PTC. Methods. We retrospectively reviewed data from 1015 patients with PTC. We calculated obese parameters, such as body mass index (BMI), body fat percentage (BFP), and body surface area (BSA). Logistic regression models were used to assess associations between obese parameters and the rate of lymph node metastasis (LNM), number of LNM, pattern of LNM, and lymph node ratio (LNR). Results. Higher BMI was not associated with different regional patterns of LNM in PTC. In men with PTC, high BFP was an independent predictor of total LNM, central lymph node metastasis (CLNM), total lateral lymph node metastasis (LLNM), multiple lateral lymph node metastasis, and simultaneous metastasis in lateral compartment. In addition, male patients with high BFP had higher central LNR and higher number of CLNM. For women, high BSA was an independent predictor of LLNM and level IV metastasis. Female patients with high BSA had higher number of CLNM. Conclusion. BFP and BSA, possibly influenced by gender, were positively associated with the number and risk of LNM in different regions of PTC patients. However, BMI was not the predictor for aggressiveness of PTC in terms of LNM. Clinical decision-making for regional LNM in PTC patients should consider the factor of obesity.http://dx.doi.org/10.1155/2022/3797955 |
| spellingShingle | Wan-Xiao Wu Jia-Wei Feng Jing Ye Gao-Feng Qi Li-Zhao Hong Jun Hu Sheng-Yong Liu Yong Jiang Zhen Qu Influence of Obesity Parameters on Different Regional Patterns of Lymph Node Metastasis in Papillary Thyroid Cancer International Journal of Endocrinology |
| title | Influence of Obesity Parameters on Different Regional Patterns of Lymph Node Metastasis in Papillary Thyroid Cancer |
| title_full | Influence of Obesity Parameters on Different Regional Patterns of Lymph Node Metastasis in Papillary Thyroid Cancer |
| title_fullStr | Influence of Obesity Parameters on Different Regional Patterns of Lymph Node Metastasis in Papillary Thyroid Cancer |
| title_full_unstemmed | Influence of Obesity Parameters on Different Regional Patterns of Lymph Node Metastasis in Papillary Thyroid Cancer |
| title_short | Influence of Obesity Parameters on Different Regional Patterns of Lymph Node Metastasis in Papillary Thyroid Cancer |
| title_sort | influence of obesity parameters on different regional patterns of lymph node metastasis in papillary thyroid cancer |
| url | http://dx.doi.org/10.1155/2022/3797955 |
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