Variables Influencing 6-Month Relapse in Early-Stage Hepatocellular Carcinoma After Radiofrequency Ablation
Objectives: Hepatocellular carcinoma (HCC) emerged as a global health concern in 2020, ranking as the sixth most diagnosed cancer and the third leading cause of cancer-related death. This study analyzed predictors of 6-month relapse in early-stage HCC patients after Radiofrequency Ablation (RFA). M...
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| Language: | English |
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Mongolian National University of Medical Sciences
2024-03-01
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| Series: | Central Asian Journal of Medical Sciences |
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| Online Access: | https://www.mongoliajol.info/index.php/CAJMS/article/view/3574 |
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| author | Yumchinserchin Narangerel Gonchigsuren Dagvasumberel Enebish Sundui Adilsaikhan Mendjargal |
| author_facet | Yumchinserchin Narangerel Gonchigsuren Dagvasumberel Enebish Sundui Adilsaikhan Mendjargal |
| author_sort | Yumchinserchin Narangerel |
| collection | DOAJ |
| description | Objectives: Hepatocellular carcinoma (HCC) emerged as a global health concern in 2020, ranking as the sixth most diagnosed cancer and the third leading cause of cancer-related death. This study analyzed predictors of 6-month relapse in early-stage HCC patients after Radiofrequency Ablation (RFA).
Methods: This retrospective study, from January 1, 2018, to December 31, 2022, meticulously explored ablation methods for early-stage HCC treatment. Data collection included a 6-month relapse definition, demographic details, and tumor-related variables.
Results: Over five years, 483 participants underwent RFA for early-stage HCC, presenting diverse demographic and tumor-related profiles. Significant associations were found between relapse and factors such as gender, smoking, alcohol use, tumor size, specific tumor locations, and pre-treatment AST levels. Notably, 6.8% of participants experienced relapse within six months. In the multivariate analysis, adjusting for confounders, smoking (p = 0.014), tumor size > 3cm (p < 0.001), tumor location S2 (p < 0.001), and pre-treatment AST levels (p = 0.015) remained significant predictors.
Conclusion: This study sheds light on the complex dynamics of 6-month relapse in early-stage HCC patients, emphasizing the significance of predictors such as smoking, tumor size, tumor location, and pre-treatment AST levels. |
| format | Article |
| id | doaj-art-fea652fe3ee64d9a9f370b4f4a457e77 |
| institution | Kabale University |
| issn | 2413-8681 2414-9772 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Mongolian National University of Medical Sciences |
| record_format | Article |
| series | Central Asian Journal of Medical Sciences |
| spelling | doaj-art-fea652fe3ee64d9a9f370b4f4a457e772025-08-20T03:47:06ZengMongolian National University of Medical SciencesCentral Asian Journal of Medical Sciences2413-86812414-97722024-03-01101152510.24079/cajms.2024.01.0033525Variables Influencing 6-Month Relapse in Early-Stage Hepatocellular Carcinoma After Radiofrequency AblationYumchinserchin Narangerel0https://orcid.org/0009-0002-0007-9620Gonchigsuren Dagvasumberel1Enebish Sundui2Adilsaikhan Mendjargal3 Department of Interventional Radiology National Cancer Center of Mongolia, Ulaanbaatar, MongoliaDepartment of Oncology, Mongolian National University of Medical Sciences, Ulaanbaatar, MongoliaDepartment of Anatomy, Mongolian National University of Medical Sciences, Ulaanbaatar, MongoliaDepartment of Radiology, Mongolian National University of Medical Sciences, Ulaanbaatar, MongoliaObjectives: Hepatocellular carcinoma (HCC) emerged as a global health concern in 2020, ranking as the sixth most diagnosed cancer and the third leading cause of cancer-related death. This study analyzed predictors of 6-month relapse in early-stage HCC patients after Radiofrequency Ablation (RFA). Methods: This retrospective study, from January 1, 2018, to December 31, 2022, meticulously explored ablation methods for early-stage HCC treatment. Data collection included a 6-month relapse definition, demographic details, and tumor-related variables. Results: Over five years, 483 participants underwent RFA for early-stage HCC, presenting diverse demographic and tumor-related profiles. Significant associations were found between relapse and factors such as gender, smoking, alcohol use, tumor size, specific tumor locations, and pre-treatment AST levels. Notably, 6.8% of participants experienced relapse within six months. In the multivariate analysis, adjusting for confounders, smoking (p = 0.014), tumor size > 3cm (p < 0.001), tumor location S2 (p < 0.001), and pre-treatment AST levels (p = 0.015) remained significant predictors. Conclusion: This study sheds light on the complex dynamics of 6-month relapse in early-stage HCC patients, emphasizing the significance of predictors such as smoking, tumor size, tumor location, and pre-treatment AST levels.https://www.mongoliajol.info/index.php/CAJMS/article/view/3574ablation safetyhepatic tumorsresidual tumorablation techniquesradiofrequency ablation |
| spellingShingle | Yumchinserchin Narangerel Gonchigsuren Dagvasumberel Enebish Sundui Adilsaikhan Mendjargal Variables Influencing 6-Month Relapse in Early-Stage Hepatocellular Carcinoma After Radiofrequency Ablation Central Asian Journal of Medical Sciences ablation safety hepatic tumors residual tumor ablation techniques radiofrequency ablation |
| title | Variables Influencing 6-Month Relapse in Early-Stage Hepatocellular Carcinoma After Radiofrequency Ablation |
| title_full | Variables Influencing 6-Month Relapse in Early-Stage Hepatocellular Carcinoma After Radiofrequency Ablation |
| title_fullStr | Variables Influencing 6-Month Relapse in Early-Stage Hepatocellular Carcinoma After Radiofrequency Ablation |
| title_full_unstemmed | Variables Influencing 6-Month Relapse in Early-Stage Hepatocellular Carcinoma After Radiofrequency Ablation |
| title_short | Variables Influencing 6-Month Relapse in Early-Stage Hepatocellular Carcinoma After Radiofrequency Ablation |
| title_sort | variables influencing 6 month relapse in early stage hepatocellular carcinoma after radiofrequency ablation |
| topic | ablation safety hepatic tumors residual tumor ablation techniques radiofrequency ablation |
| url | https://www.mongoliajol.info/index.php/CAJMS/article/view/3574 |
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