Dickkopf-1 Is a Biomarker for Systemic Lupus Erythematosus and Active Lupus Nephritis
An early diagnosis of lupus nephritis (LN) has an important clinical implication in guiding treatments of systemic lupus erythematosus (SLE) in clinical settings. In this study, the concentrations of Wnt-3A, Frizzled-8 (FZD-8), and Dickkopf-1 (DKK-1) of Wnt signaling, as well as their diagnostic val...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2017/6861575 |
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| author | Jing Xue Jiali Yang Lijuan Yang Shaolan Zhou Chen Ji Xuemei Wang Nan Yu Xiaoming Liu Shuhong Chi |
| author_facet | Jing Xue Jiali Yang Lijuan Yang Shaolan Zhou Chen Ji Xuemei Wang Nan Yu Xiaoming Liu Shuhong Chi |
| author_sort | Jing Xue |
| collection | DOAJ |
| description | An early diagnosis of lupus nephritis (LN) has an important clinical implication in guiding treatments of systemic lupus erythematosus (SLE) in clinical settings. In this study, the concentrations of Wnt-3A, Frizzled-8 (FZD-8), and Dickkopf-1 (DKK-1) of Wnt signaling, as well as their diagnostic values for accessing LN, were evaluated by ELISA in sera and urine of 111 SLE patients (31 with LN and 80 without LN) and 70 healthy cohorts. Significantly more abundances of DKK-1 protein were determined in both of sera and urine of SLE patients compared to healthy cohorts (p<0.0001); in particular the serum DKK-1 concentration was even higher in LN-SLE patients relative to non-LN SLE subjects (p<0.0001). Intriguingly, concentrations of above examined proteins in SLE patients showed no correlation between serum and urine. Moreover, a combination of DKK-1 with anti-dsDNA and/or levels of complement C3 and C4 could not increase the specificity and/or sensitivity for identification of patients with LN diseases, but both ROC curve and multiple-factor nonconditional logistic regression analysis showed that serum DKK-1 was considered better positive biomarker for identification of LN in SLE patients. These results imply that serum and/or urine DKK-1 may be a valuable and independent biomarker for identification of SLE patients with LN. |
| format | Article |
| id | doaj-art-fea33d63cf38475d8da731234018a8bf |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-fea33d63cf38475d8da731234018a8bf2025-02-03T00:59:09ZengWileyJournal of Immunology Research2314-88612314-71562017-01-01201710.1155/2017/68615756861575Dickkopf-1 Is a Biomarker for Systemic Lupus Erythematosus and Active Lupus NephritisJing Xue0Jiali Yang1Lijuan Yang2Shaolan Zhou3Chen Ji4Xuemei Wang5Nan Yu6Xiaoming Liu7Shuhong Chi8The General Hospital of Ningxia Medical University, Yinchuan 750004, ChinaThe General Hospital of Ningxia Medical University, Yinchuan 750004, ChinaDepartment of Rheumatology, The General Hospital of Ningxia Medical University, Yinchuan 750004, ChinaDepartment of Rheumatology, The General Hospital of Ningxia Medical University, Yinchuan 750004, ChinaDepartment of Rheumatology, The General Hospital of Ningxia Medical University, Yinchuan 750004, ChinaDepartment of Rheumatology, The General Hospital of Ningxia Medical University, Yinchuan 750004, ChinaDepartment of Rheumatology, The General Hospital of Ningxia Medical University, Yinchuan 750004, ChinaThe General Hospital of Ningxia Medical University, Yinchuan 750004, ChinaDepartment of Rheumatology, The General Hospital of Ningxia Medical University, Yinchuan 750004, ChinaAn early diagnosis of lupus nephritis (LN) has an important clinical implication in guiding treatments of systemic lupus erythematosus (SLE) in clinical settings. In this study, the concentrations of Wnt-3A, Frizzled-8 (FZD-8), and Dickkopf-1 (DKK-1) of Wnt signaling, as well as their diagnostic values for accessing LN, were evaluated by ELISA in sera and urine of 111 SLE patients (31 with LN and 80 without LN) and 70 healthy cohorts. Significantly more abundances of DKK-1 protein were determined in both of sera and urine of SLE patients compared to healthy cohorts (p<0.0001); in particular the serum DKK-1 concentration was even higher in LN-SLE patients relative to non-LN SLE subjects (p<0.0001). Intriguingly, concentrations of above examined proteins in SLE patients showed no correlation between serum and urine. Moreover, a combination of DKK-1 with anti-dsDNA and/or levels of complement C3 and C4 could not increase the specificity and/or sensitivity for identification of patients with LN diseases, but both ROC curve and multiple-factor nonconditional logistic regression analysis showed that serum DKK-1 was considered better positive biomarker for identification of LN in SLE patients. These results imply that serum and/or urine DKK-1 may be a valuable and independent biomarker for identification of SLE patients with LN.http://dx.doi.org/10.1155/2017/6861575 |
| spellingShingle | Jing Xue Jiali Yang Lijuan Yang Shaolan Zhou Chen Ji Xuemei Wang Nan Yu Xiaoming Liu Shuhong Chi Dickkopf-1 Is a Biomarker for Systemic Lupus Erythematosus and Active Lupus Nephritis Journal of Immunology Research |
| title | Dickkopf-1 Is a Biomarker for Systemic Lupus Erythematosus and Active Lupus Nephritis |
| title_full | Dickkopf-1 Is a Biomarker for Systemic Lupus Erythematosus and Active Lupus Nephritis |
| title_fullStr | Dickkopf-1 Is a Biomarker for Systemic Lupus Erythematosus and Active Lupus Nephritis |
| title_full_unstemmed | Dickkopf-1 Is a Biomarker for Systemic Lupus Erythematosus and Active Lupus Nephritis |
| title_short | Dickkopf-1 Is a Biomarker for Systemic Lupus Erythematosus and Active Lupus Nephritis |
| title_sort | dickkopf 1 is a biomarker for systemic lupus erythematosus and active lupus nephritis |
| url | http://dx.doi.org/10.1155/2017/6861575 |
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