Prevention of Ovarian Hyperstimulation Syndrome: A Review

The following review aims to examine the available evidence to guide best practice in preventing ovarian hyperstimulation syndrome (OHSS). As it stands, there is no single method to completely prevent OHSS. There seems to be a benefit, however, in categorizing women based on their risk of OHSS and i...

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Main Authors: Vinayak Smith, Tiki Osianlis, Beverley Vollenhoven
Format: Article
Language:English
Published: Wiley 2015-01-01
Series:Obstetrics and Gynecology International
Online Access:http://dx.doi.org/10.1155/2015/514159
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author Vinayak Smith
Tiki Osianlis
Beverley Vollenhoven
author_facet Vinayak Smith
Tiki Osianlis
Beverley Vollenhoven
author_sort Vinayak Smith
collection DOAJ
description The following review aims to examine the available evidence to guide best practice in preventing ovarian hyperstimulation syndrome (OHSS). As it stands, there is no single method to completely prevent OHSS. There seems to be a benefit, however, in categorizing women based on their risk of OHSS and individualizing treatments to curtail their chances of developing the syndrome. At present, both Anti-Müllerian Hormone and the antral follicle count seem to be promising in this regard. Both available and upcoming therapies are also reviewed to give a broad perspective to clinicians with regard to management options. At present, we recommend the use of a “step-up” regimen for ovulation induction, adjunct metformin utilization, utilizing a GnRH agonist as an ovulation trigger, and cabergoline usage. A summary of recommendations is also made available for ease of clinical application. In addition, areas for potential research are also identified where relevant.
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series Obstetrics and Gynecology International
spelling doaj-art-fe9db7738a3641a4979e4cd68997cfe02025-08-20T03:25:46ZengWileyObstetrics and Gynecology International1687-95891687-95972015-01-01201510.1155/2015/514159514159Prevention of Ovarian Hyperstimulation Syndrome: A ReviewVinayak Smith0Tiki Osianlis1Beverley Vollenhoven2Alice Springs Hospital, Department of Obstetrics and Gynaecology, Alice Springs, NT 0870, AustraliaMonash IVF, 252 Clayton Road, Clayton, VIC 3168, AustraliaMonash IVF, 252 Clayton Road, Clayton, VIC 3168, AustraliaThe following review aims to examine the available evidence to guide best practice in preventing ovarian hyperstimulation syndrome (OHSS). As it stands, there is no single method to completely prevent OHSS. There seems to be a benefit, however, in categorizing women based on their risk of OHSS and individualizing treatments to curtail their chances of developing the syndrome. At present, both Anti-Müllerian Hormone and the antral follicle count seem to be promising in this regard. Both available and upcoming therapies are also reviewed to give a broad perspective to clinicians with regard to management options. At present, we recommend the use of a “step-up” regimen for ovulation induction, adjunct metformin utilization, utilizing a GnRH agonist as an ovulation trigger, and cabergoline usage. A summary of recommendations is also made available for ease of clinical application. In addition, areas for potential research are also identified where relevant.http://dx.doi.org/10.1155/2015/514159
spellingShingle Vinayak Smith
Tiki Osianlis
Beverley Vollenhoven
Prevention of Ovarian Hyperstimulation Syndrome: A Review
Obstetrics and Gynecology International
title Prevention of Ovarian Hyperstimulation Syndrome: A Review
title_full Prevention of Ovarian Hyperstimulation Syndrome: A Review
title_fullStr Prevention of Ovarian Hyperstimulation Syndrome: A Review
title_full_unstemmed Prevention of Ovarian Hyperstimulation Syndrome: A Review
title_short Prevention of Ovarian Hyperstimulation Syndrome: A Review
title_sort prevention of ovarian hyperstimulation syndrome a review
url http://dx.doi.org/10.1155/2015/514159
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