Deciphering Pain and Pruritus in Keloids from the Perspective of Neurological Dysfunction: Where Are We Now?
Keloids are a typical skin fibroproliferative disease that can cause severe aesthetic and functional concerns. Pain and pruritus are the most common clinical symptoms of keloids, but the mechanisms underlying these symptoms remain unclear. The peripheral nervous system plays a pivotal role in the tr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-03-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/13/3/663 |
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| author | En Yang Ruoqing Xu Hanrui Zhang Wenzheng Xia Xin Huang Tao Zan |
| author_facet | En Yang Ruoqing Xu Hanrui Zhang Wenzheng Xia Xin Huang Tao Zan |
| author_sort | En Yang |
| collection | DOAJ |
| description | Keloids are a typical skin fibroproliferative disease that can cause severe aesthetic and functional concerns. Pain and pruritus are the most common clinical symptoms of keloids, but the mechanisms underlying these symptoms remain unclear. The peripheral nervous system plays a pivotal role in the transmission of superficial sensation signals. Mounting evidence has shown potential correlations between disturbance in the peripheral nervous system and pain and pruritus in keloids. Here, we summarize the role of neurological dysfunction in the development of pain and pruritus, with a specific focus on neuroanatomical alterations, the dysfunction of sensory nerves, and neurogenic inflammation. |
| format | Article |
| id | doaj-art-fe99c02dfecf486eb6785015955ff3c6 |
| institution | OA Journals |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-fe99c02dfecf486eb6785015955ff3c62025-08-20T02:11:15ZengMDPI AGBiomedicines2227-90592025-03-0113366310.3390/biomedicines13030663Deciphering Pain and Pruritus in Keloids from the Perspective of Neurological Dysfunction: Where Are We Now?En Yang0Ruoqing Xu1Hanrui Zhang2Wenzheng Xia3Xin Huang4Tao Zan5Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200021, ChinaDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200021, ChinaDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200021, ChinaDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200021, ChinaDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200021, ChinaDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200021, ChinaKeloids are a typical skin fibroproliferative disease that can cause severe aesthetic and functional concerns. Pain and pruritus are the most common clinical symptoms of keloids, but the mechanisms underlying these symptoms remain unclear. The peripheral nervous system plays a pivotal role in the transmission of superficial sensation signals. Mounting evidence has shown potential correlations between disturbance in the peripheral nervous system and pain and pruritus in keloids. Here, we summarize the role of neurological dysfunction in the development of pain and pruritus, with a specific focus on neuroanatomical alterations, the dysfunction of sensory nerves, and neurogenic inflammation.https://www.mdpi.com/2227-9059/13/3/663keloidprurituspainneurological dysfunctionSchwann cell |
| spellingShingle | En Yang Ruoqing Xu Hanrui Zhang Wenzheng Xia Xin Huang Tao Zan Deciphering Pain and Pruritus in Keloids from the Perspective of Neurological Dysfunction: Where Are We Now? Biomedicines keloid pruritus pain neurological dysfunction Schwann cell |
| title | Deciphering Pain and Pruritus in Keloids from the Perspective of Neurological Dysfunction: Where Are We Now? |
| title_full | Deciphering Pain and Pruritus in Keloids from the Perspective of Neurological Dysfunction: Where Are We Now? |
| title_fullStr | Deciphering Pain and Pruritus in Keloids from the Perspective of Neurological Dysfunction: Where Are We Now? |
| title_full_unstemmed | Deciphering Pain and Pruritus in Keloids from the Perspective of Neurological Dysfunction: Where Are We Now? |
| title_short | Deciphering Pain and Pruritus in Keloids from the Perspective of Neurological Dysfunction: Where Are We Now? |
| title_sort | deciphering pain and pruritus in keloids from the perspective of neurological dysfunction where are we now |
| topic | keloid pruritus pain neurological dysfunction Schwann cell |
| url | https://www.mdpi.com/2227-9059/13/3/663 |
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