Immediate and long-term effects of COVID-19 on antibiotic dispensing: increasing use of Watch antibiotics
Introduction: The coronavirus disease 2019 (COVID-19) pandemic affected antibiotic usage worldwide. However, there is limited data from Serbia. Dispensing of oral antibiotics in Serbian pharmacies was analyzed to calculate monthly and yearly changes between 2018-2021, and to explore immediate and l...
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The Journal of Infection in Developing Countries
2024-04-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/19255 |
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| author | Tanja Tomic Martin Henman Ivana Tadic Jelena Antic Stankovic Milena Santric Milicevic Zoran Bukumiric Dragana Lakic Marina Odalovic |
| author_facet | Tanja Tomic Martin Henman Ivana Tadic Jelena Antic Stankovic Milena Santric Milicevic Zoran Bukumiric Dragana Lakic Marina Odalovic |
| author_sort | Tanja Tomic |
| collection | DOAJ |
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Introduction: The coronavirus disease 2019 (COVID-19) pandemic affected antibiotic usage worldwide. However, there is limited data from Serbia. Dispensing of oral antibiotics in Serbian pharmacies was analyzed to calculate monthly and yearly changes between 2018-2021, and to explore immediate and long-term effects of COVID-19 on antibiotic dispensing during this period.
Methodology: The number of antibiotic packages dispensed from pharmacies during the study period was analyzed with a Chi-square test to assess the average change in annual dispensing, and an interrupted time-series analysis was used to evaluate the impact of the pandemic on antibiotic dispensing. The data from 2018-2021 were retrieved from the database of a large community pharmacy chain in Serbia.
Results: The average number of antibiotic packages dispensed per day and per pharmacy was higher in 2021 compared to 2018 by one package. However, the dispensing of macrolides increased significantly; 17.7% (2018) vs. 22.5% (2021) (p < 0.05). In general, an increase in antibiotic dispensing was detected during COVID-19 for total antibiotics (16.4%), Watch antibiotics (44.8%), third-generation cephalosporins (80.4%), macrolides (45.5%) and azithromycin (83.7%). However, the immediate effect of COVID-19 was a decrease in the dispensing of Watch antibiotics, penicillin, and third-generation cephalosporins (p < 0.05); and a notable long-term COVID-19 effect was an increase in the dispensing of azithromycin (p < 0.05).
Conclusions: In spite of a relatively stable trend of total antibiotic dispensing before and during COVID-19 pandemic, the use of Watch antibiotics, third-generation cephalosporins, and macrolides (particularly azithromycin) showed an increasing trend in dispensing that should be optimized.
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| format | Article |
| id | doaj-art-fe991c2737ef4de8919fc3fbf35d17a0 |
| institution | OA Journals |
| issn | 1972-2680 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-fe991c2737ef4de8919fc3fbf35d17a02025-08-20T02:27:22ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802024-04-01180410.3855/jidc.19255Immediate and long-term effects of COVID-19 on antibiotic dispensing: increasing use of Watch antibioticsTanja Tomic0Martin Henman1Ivana Tadic2Jelena Antic Stankovic3Milena Santric Milicevic4Zoran Bukumiric5Dragana Lakic6Marina Odalovic7Faculty of Pharmacy, University of Belgrade, Belgrade, SerbiaSchool of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Dublin, IrelandFaculty of Pharmacy, University of Belgrade, Belgrade, SerbiaFaculty of Pharmacy, University of Belgrade, Belgrade, SerbiaFaculty of Medicine, University of Belgrade, Belgrade, SerbiaFaculty of Medicine, University of Belgrade, Belgrade, SerbiaFaculty of Pharmacy, University of Belgrade, Belgrade, SerbiaFaculty of Pharmacy, University of Belgrade, Belgrade, Serbia Introduction: The coronavirus disease 2019 (COVID-19) pandemic affected antibiotic usage worldwide. However, there is limited data from Serbia. Dispensing of oral antibiotics in Serbian pharmacies was analyzed to calculate monthly and yearly changes between 2018-2021, and to explore immediate and long-term effects of COVID-19 on antibiotic dispensing during this period. Methodology: The number of antibiotic packages dispensed from pharmacies during the study period was analyzed with a Chi-square test to assess the average change in annual dispensing, and an interrupted time-series analysis was used to evaluate the impact of the pandemic on antibiotic dispensing. The data from 2018-2021 were retrieved from the database of a large community pharmacy chain in Serbia. Results: The average number of antibiotic packages dispensed per day and per pharmacy was higher in 2021 compared to 2018 by one package. However, the dispensing of macrolides increased significantly; 17.7% (2018) vs. 22.5% (2021) (p < 0.05). In general, an increase in antibiotic dispensing was detected during COVID-19 for total antibiotics (16.4%), Watch antibiotics (44.8%), third-generation cephalosporins (80.4%), macrolides (45.5%) and azithromycin (83.7%). However, the immediate effect of COVID-19 was a decrease in the dispensing of Watch antibiotics, penicillin, and third-generation cephalosporins (p < 0.05); and a notable long-term COVID-19 effect was an increase in the dispensing of azithromycin (p < 0.05). Conclusions: In spite of a relatively stable trend of total antibiotic dispensing before and during COVID-19 pandemic, the use of Watch antibiotics, third-generation cephalosporins, and macrolides (particularly azithromycin) showed an increasing trend in dispensing that should be optimized. https://jidc.org/index.php/journal/article/view/19255antibioticdrug dispensingCOVID-19bacterial resistanceSerbia |
| spellingShingle | Tanja Tomic Martin Henman Ivana Tadic Jelena Antic Stankovic Milena Santric Milicevic Zoran Bukumiric Dragana Lakic Marina Odalovic Immediate and long-term effects of COVID-19 on antibiotic dispensing: increasing use of Watch antibiotics Journal of Infection in Developing Countries antibiotic drug dispensing COVID-19 bacterial resistance Serbia |
| title | Immediate and long-term effects of COVID-19 on antibiotic dispensing: increasing use of Watch antibiotics |
| title_full | Immediate and long-term effects of COVID-19 on antibiotic dispensing: increasing use of Watch antibiotics |
| title_fullStr | Immediate and long-term effects of COVID-19 on antibiotic dispensing: increasing use of Watch antibiotics |
| title_full_unstemmed | Immediate and long-term effects of COVID-19 on antibiotic dispensing: increasing use of Watch antibiotics |
| title_short | Immediate and long-term effects of COVID-19 on antibiotic dispensing: increasing use of Watch antibiotics |
| title_sort | immediate and long term effects of covid 19 on antibiotic dispensing increasing use of watch antibiotics |
| topic | antibiotic drug dispensing COVID-19 bacterial resistance Serbia |
| url | https://jidc.org/index.php/journal/article/view/19255 |
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