Changes in corneal higher-order aberrations following PreserFlo MicroShunt implantation
Abstract In this retrospective study, we evaluated changes in corneal higher-order aberrations (HOAs) after PreserFlo MicroShunt (PFM) implantation and examined factors associated with the outcomes. We included 101 PFM implantations performed between February 2023 and June 2024. Visual acuity, intra...
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Nature Portfolio
2025-05-01
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| Online Access: | https://doi.org/10.1038/s41598-025-01550-w |
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| author | Taro Baba Kazuyuki Hirooka Naoki Okada Hiromitsu Onoe Kana Tokumo Hideaki Okumichi Yoshiaki Kiuchi Hirokazu Sakaguchi |
| author_facet | Taro Baba Kazuyuki Hirooka Naoki Okada Hiromitsu Onoe Kana Tokumo Hideaki Okumichi Yoshiaki Kiuchi Hirokazu Sakaguchi |
| author_sort | Taro Baba |
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| description | Abstract In this retrospective study, we evaluated changes in corneal higher-order aberrations (HOAs) after PreserFlo MicroShunt (PFM) implantation and examined factors associated with the outcomes. We included 101 PFM implantations performed between February 2023 and June 2024. Visual acuity, intraocular pressure, corneal HOAs, and coma-like and spherical aberrations were analyzed preoperatively, at 1 week, and at 1, 2, and 3 months postoperatively. Generalized linear mixed models were used to analyze factors that might affect HOAs and other aberrations. Preoperatively, HOAs, coma-like aberrations, and spherical-like aberrations were 0.249 ± 0.192, 0.216 ± 0.180, and 0.109 ± 0.093 μm, respectively. Aberrations showed a significant increase up to 1 month postoperatively, peaking at 1 week, with values of 0.396 ± 0.210 μm, 0.346 ± 0.204 μm, and 0.173 ± 0.105 μm, respectively (all P < 0.001). The aberrations were no longer significantly greater than baseline at 2 and 3 months postoperatively. Analysis of risk factors suggested that post-implantation hypotony (≤ 5 mmHg) could influence corneal HOAs and coma-like aberrations. PFM implantation temporarily increased corneal HOAs, coma-like aberrations, and spherical aberrations, but these levels stabilized and had returned to preoperative levels by 2 months postoperatively. Postoperative hypotony was associated with increased corneal HOAs and coma-like aberrations. |
| format | Article |
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| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-05-01 |
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| spelling | doaj-art-fe9457b86c524f54b4e9f5cd72243a8a2025-08-20T03:10:17ZengNature PortfolioScientific Reports2045-23222025-05-011511710.1038/s41598-025-01550-wChanges in corneal higher-order aberrations following PreserFlo MicroShunt implantationTaro Baba0Kazuyuki Hirooka1Naoki Okada2Hiromitsu Onoe3Kana Tokumo4Hideaki Okumichi5Yoshiaki Kiuchi6Hirokazu Sakaguchi7Department of Ophthalmology and Visual Science, Hiroshima UniversityDepartment of Ophthalmology and Visual Science, Hiroshima UniversityDepartment of Ophthalmology and Visual Science, Hiroshima UniversityDepartment of Ophthalmology and Visual Science, Hiroshima UniversityDepartment of Ophthalmology and Visual Science, Hiroshima UniversityDepartment of Ophthalmology and Visual Science, Hiroshima UniversityDepartment of Ophthalmology and Visual Science, Hiroshima UniversityDepartment of Ophthalmology and Visual Science, Hiroshima UniversityAbstract In this retrospective study, we evaluated changes in corneal higher-order aberrations (HOAs) after PreserFlo MicroShunt (PFM) implantation and examined factors associated with the outcomes. We included 101 PFM implantations performed between February 2023 and June 2024. Visual acuity, intraocular pressure, corneal HOAs, and coma-like and spherical aberrations were analyzed preoperatively, at 1 week, and at 1, 2, and 3 months postoperatively. Generalized linear mixed models were used to analyze factors that might affect HOAs and other aberrations. Preoperatively, HOAs, coma-like aberrations, and spherical-like aberrations were 0.249 ± 0.192, 0.216 ± 0.180, and 0.109 ± 0.093 μm, respectively. Aberrations showed a significant increase up to 1 month postoperatively, peaking at 1 week, with values of 0.396 ± 0.210 μm, 0.346 ± 0.204 μm, and 0.173 ± 0.105 μm, respectively (all P < 0.001). The aberrations were no longer significantly greater than baseline at 2 and 3 months postoperatively. Analysis of risk factors suggested that post-implantation hypotony (≤ 5 mmHg) could influence corneal HOAs and coma-like aberrations. PFM implantation temporarily increased corneal HOAs, coma-like aberrations, and spherical aberrations, but these levels stabilized and had returned to preoperative levels by 2 months postoperatively. Postoperative hypotony was associated with increased corneal HOAs and coma-like aberrations.https://doi.org/10.1038/s41598-025-01550-wPreserFlo microshuntCorneal higher-order aberrationsGlaucoma |
| spellingShingle | Taro Baba Kazuyuki Hirooka Naoki Okada Hiromitsu Onoe Kana Tokumo Hideaki Okumichi Yoshiaki Kiuchi Hirokazu Sakaguchi Changes in corneal higher-order aberrations following PreserFlo MicroShunt implantation Scientific Reports PreserFlo microshunt Corneal higher-order aberrations Glaucoma |
| title | Changes in corneal higher-order aberrations following PreserFlo MicroShunt implantation |
| title_full | Changes in corneal higher-order aberrations following PreserFlo MicroShunt implantation |
| title_fullStr | Changes in corneal higher-order aberrations following PreserFlo MicroShunt implantation |
| title_full_unstemmed | Changes in corneal higher-order aberrations following PreserFlo MicroShunt implantation |
| title_short | Changes in corneal higher-order aberrations following PreserFlo MicroShunt implantation |
| title_sort | changes in corneal higher order aberrations following preserflo microshunt implantation |
| topic | PreserFlo microshunt Corneal higher-order aberrations Glaucoma |
| url | https://doi.org/10.1038/s41598-025-01550-w |
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