Differential Diagnosis of Peripheral Lung Lesions: Capabilities and Limitations of Current Methods
This article analyzes 63 scientific works dedicated to the diagnosis of peripheral lung lesions (PLL). The differential diagnosis of PLL poses challenges due to the diversity of underlying pathologies, which may include tuberculoma, cancer, and benign tumors. The absence of a unified diagnostic algo...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Bashkir State Medical University
2025-07-01
|
| Series: | Креативная хирургия и онкология |
| Subjects: | |
| Online Access: | https://www.surgonco.ru/jour/article/view/1088 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849249741216415744 |
|---|---|
| author | R. N. Islamov R. A. Sharipov M. A. Bagirov R. K. Tukfatullin G. V. Chitorelidze E. V. Pavlova R. K. Yagafarova |
| author_facet | R. N. Islamov R. A. Sharipov M. A. Bagirov R. K. Tukfatullin G. V. Chitorelidze E. V. Pavlova R. K. Yagafarova |
| author_sort | R. N. Islamov |
| collection | DOAJ |
| description | This article analyzes 63 scientific works dedicated to the diagnosis of peripheral lung lesions (PLL). The differential diagnosis of PLL poses challenges due to the diversity of underlying pathologies, which may include tuberculoma, cancer, and benign tumors. The absence of a unified diagnostic algorithm often necessitates surgical intervention. Non-invasive methods, including radiography, computed tomography (CT), positron emission tomography (PET), and sputum analysis, exhibit limited diagnostic yield, particularly for small lesions. The combination of fiberoptic bronchoscopy with endoscopic ultrasound (EUS) and transthoracic biopsy enhances diagnostic accuracy; however, they carry risks such as pneumothorax. Video-assisted thoracoscopic surgery (VATS) is an effective modality when biopsies are inconclusive, especially for lesions of less than 3 cm. It ensures high diagnostic accuracy and reduces hospitalization duration. Videoassisted thoracoscopic biopsy offers diagnostic accuracy comparable to that of open biopsy, while exhibiting reduced invasiveness. Conventional thoracotomy remains indicated for large or hard-to-reach lesions. It is recommended that a comprehensive approach combining CT, characterized by high informative value, and PET scan, characterized by high sensitivity and specificity for nodules >10 mm, with invasive methods be used. VATS proves effective for lesions below 3 cm, while thoracotomy is applied to large lesions. An individualized approach remains essential for optimal diagnosis. Despite the advancements, the challenge of differential diagnosis persists. |
| format | Article |
| id | doaj-art-fe93865661464152b5acc207767e390f |
| institution | Kabale University |
| issn | 2076-3093 2307-0501 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Bashkir State Medical University |
| record_format | Article |
| series | Креативная хирургия и онкология |
| spelling | doaj-art-fe93865661464152b5acc207767e390f2025-08-20T03:57:27ZengBashkir State Medical UniversityКреативная хирургия и онкология2076-30932307-05012025-07-0115216017010.24060/2076-3093-2025-15-2-64-74625Differential Diagnosis of Peripheral Lung Lesions: Capabilities and Limitations of Current MethodsR. N. Islamov0R. A. Sharipov1M. A. Bagirov2R. K. Tukfatullin3G. V. Chitorelidze4E. V. Pavlova5R. K. Yagafarova6Bashkir State Medical University ; Republican Clinical Phthisiopulmonology CenterBashkir State Medical UniversityCentral Scientific Research Institute of Tuberculosis ; Russian Medical Academy of Postgraduate EducationBashkir State Medical UniversityCentral Scientific Research Institute of TuberculosisBashkir State Medical UniversityBashkir State Medical UniversityThis article analyzes 63 scientific works dedicated to the diagnosis of peripheral lung lesions (PLL). The differential diagnosis of PLL poses challenges due to the diversity of underlying pathologies, which may include tuberculoma, cancer, and benign tumors. The absence of a unified diagnostic algorithm often necessitates surgical intervention. Non-invasive methods, including radiography, computed tomography (CT), positron emission tomography (PET), and sputum analysis, exhibit limited diagnostic yield, particularly for small lesions. The combination of fiberoptic bronchoscopy with endoscopic ultrasound (EUS) and transthoracic biopsy enhances diagnostic accuracy; however, they carry risks such as pneumothorax. Video-assisted thoracoscopic surgery (VATS) is an effective modality when biopsies are inconclusive, especially for lesions of less than 3 cm. It ensures high diagnostic accuracy and reduces hospitalization duration. Videoassisted thoracoscopic biopsy offers diagnostic accuracy comparable to that of open biopsy, while exhibiting reduced invasiveness. Conventional thoracotomy remains indicated for large or hard-to-reach lesions. It is recommended that a comprehensive approach combining CT, characterized by high informative value, and PET scan, characterized by high sensitivity and specificity for nodules >10 mm, with invasive methods be used. VATS proves effective for lesions below 3 cm, while thoracotomy is applied to large lesions. An individualized approach remains essential for optimal diagnosis. Despite the advancements, the challenge of differential diagnosis persists.https://www.surgonco.ru/jour/article/view/1088lung neoplasmsvideo-assisted thoracoscopythoracotomytransthoracic biopsycomputed tomographydifferential diagnosisbronchoscopyradial endobronchial ultrasoundvideo-assisted thoracoscopic surgery |
| spellingShingle | R. N. Islamov R. A. Sharipov M. A. Bagirov R. K. Tukfatullin G. V. Chitorelidze E. V. Pavlova R. K. Yagafarova Differential Diagnosis of Peripheral Lung Lesions: Capabilities and Limitations of Current Methods Креативная хирургия и онкология lung neoplasms video-assisted thoracoscopy thoracotomy transthoracic biopsy computed tomography differential diagnosis bronchoscopy radial endobronchial ultrasound video-assisted thoracoscopic surgery |
| title | Differential Diagnosis of Peripheral Lung Lesions: Capabilities and Limitations of Current Methods |
| title_full | Differential Diagnosis of Peripheral Lung Lesions: Capabilities and Limitations of Current Methods |
| title_fullStr | Differential Diagnosis of Peripheral Lung Lesions: Capabilities and Limitations of Current Methods |
| title_full_unstemmed | Differential Diagnosis of Peripheral Lung Lesions: Capabilities and Limitations of Current Methods |
| title_short | Differential Diagnosis of Peripheral Lung Lesions: Capabilities and Limitations of Current Methods |
| title_sort | differential diagnosis of peripheral lung lesions capabilities and limitations of current methods |
| topic | lung neoplasms video-assisted thoracoscopy thoracotomy transthoracic biopsy computed tomography differential diagnosis bronchoscopy radial endobronchial ultrasound video-assisted thoracoscopic surgery |
| url | https://www.surgonco.ru/jour/article/view/1088 |
| work_keys_str_mv | AT rnislamov differentialdiagnosisofperipherallunglesionscapabilitiesandlimitationsofcurrentmethods AT rasharipov differentialdiagnosisofperipherallunglesionscapabilitiesandlimitationsofcurrentmethods AT mabagirov differentialdiagnosisofperipherallunglesionscapabilitiesandlimitationsofcurrentmethods AT rktukfatullin differentialdiagnosisofperipherallunglesionscapabilitiesandlimitationsofcurrentmethods AT gvchitorelidze differentialdiagnosisofperipherallunglesionscapabilitiesandlimitationsofcurrentmethods AT evpavlova differentialdiagnosisofperipherallunglesionscapabilitiesandlimitationsofcurrentmethods AT rkyagafarova differentialdiagnosisofperipherallunglesionscapabilitiesandlimitationsofcurrentmethods |