Research on the clinical and pathological characteristics of primary orbital neoplastic lesions with communication
Abstract Objective To comprehensively summarize the clinical and pathological characteristics of primary orbital neoplastic lesions with communication, thereby providing a solid basis for the diagnosis and treatment of such conditions. Method A retrospective analysis of clinical cases was conducted....
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| Language: | English |
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BMC
2025-05-01
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| Series: | BMC Ophthalmology |
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| Online Access: | https://doi.org/10.1186/s12886-025-04118-4 |
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| author | Lian Wang Jing Zhang Shuo Zhang Bin Li Bentao Yang Hongjuan Liu Chunli Chen Qiong Wu Libin Jiang |
| author_facet | Lian Wang Jing Zhang Shuo Zhang Bin Li Bentao Yang Hongjuan Liu Chunli Chen Qiong Wu Libin Jiang |
| author_sort | Lian Wang |
| collection | DOAJ |
| description | Abstract Objective To comprehensively summarize the clinical and pathological characteristics of primary orbital neoplastic lesions with communication, thereby providing a solid basis for the diagnosis and treatment of such conditions. Method A retrospective analysis of clinical cases was conducted. The clinical and pathological data of 862 patients diagnosed with primary orbital neoplasms with communication, including orbito-cranial, orbito-nasal, and orbito-crano-nasal communicating tumors, were collected. The data covered gender distribution, age at onset, presenting symptoms and signs, imaging findings, and treatment modalities. These data were systematically summarized according to pathological diagnoses. Results Among all primary orbito-related communication neoplasms, meningioma was identified as the most common benign tumor (11.0%, 95/862), with a mean age of onset of 45.3 ± 12.7 years. Notably, 72.6% of meningiomas originated from the orbit, while 27.4% originated from intracranial sites. In contrast, adenoid cystic carcinoma was the most common malignant tumor (9.5%, 82/862), with a mean age of onset of 39.1 ± 12.8 years. The majority of adenoid cystic carcinomas (59.8%) originated from the orbit, whereas 29.3% originated from the sinuses. In the pediatric population under the age of 14 years, a total of 102 cases were identified. Out of these, there were 67 cases of orbito-cranial communication (65.7%), 5 cases of orbito-nasal communication (4.9%), and 30 cases of orbito-crano-nasal communication (29.4%). Optic glioma was the most common benign tumor in pediatric orbito-cranial communication (22.4%, 15/67), with an average age of onset at 5.6 ± 4.2 years. The most prevalent malignant tumor among children with orbito-cranial communication was small round cell tumor (10.4%, 7/67), with an average age of onset at 4.6 ± 3.7 years. In children with orbital-cranio-nasal communication, sarcoma was identified as the most common malignant tumor (43.3%, 13/30), with 76.9% of tumors originating from the nose. The most common benign tumor in this group was nasopharyngeal fibroangioma (16.7%, 5/30), which exclusively affected males and originated from the nasopharynx. Conclusion The clinical features and pathological classification of primary orbital tumors vary significantly depending on the type of communication. Moreover, there are substantial differences in the pathological subtypes of these orbital lesions between children and adults. |
| format | Article |
| id | doaj-art-fe8b4995d86142ed893447cd996e81ae |
| institution | DOAJ |
| issn | 1471-2415 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj-art-fe8b4995d86142ed893447cd996e81ae2025-08-20T03:22:01ZengBMCBMC Ophthalmology1471-24152025-05-0125111010.1186/s12886-025-04118-4Research on the clinical and pathological characteristics of primary orbital neoplastic lesions with communicationLian Wang0Jing Zhang1Shuo Zhang2Bin Li3Bentao Yang4Hongjuan Liu5Chunli Chen6Qiong Wu7Libin Jiang8Ophthalmology Department, Beijing Puren HospitalOphthalmology Department, Beijing Puren HospitalBeijing Tongren Hospital, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Eye Center, Capital Medical UniversityInstitute of Ophthalmology, Beijing Tongren Hospital, Beijing Tongren Eye Center, Capital Medical UniversityDepartment of Radiology, Beijing Tongren Hospital, Capital Medical UniversityBeijing Tongren Hospital, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Eye Center, Capital Medical UniversityBeijing Tongren Hospital, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Eye Center, Capital Medical UniversityBeijing Tongren Hospital, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Eye Center, Capital Medical UniversityBeijing Tongren Hospital, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Eye Center, Capital Medical UniversityAbstract Objective To comprehensively summarize the clinical and pathological characteristics of primary orbital neoplastic lesions with communication, thereby providing a solid basis for the diagnosis and treatment of such conditions. Method A retrospective analysis of clinical cases was conducted. The clinical and pathological data of 862 patients diagnosed with primary orbital neoplasms with communication, including orbito-cranial, orbito-nasal, and orbito-crano-nasal communicating tumors, were collected. The data covered gender distribution, age at onset, presenting symptoms and signs, imaging findings, and treatment modalities. These data were systematically summarized according to pathological diagnoses. Results Among all primary orbito-related communication neoplasms, meningioma was identified as the most common benign tumor (11.0%, 95/862), with a mean age of onset of 45.3 ± 12.7 years. Notably, 72.6% of meningiomas originated from the orbit, while 27.4% originated from intracranial sites. In contrast, adenoid cystic carcinoma was the most common malignant tumor (9.5%, 82/862), with a mean age of onset of 39.1 ± 12.8 years. The majority of adenoid cystic carcinomas (59.8%) originated from the orbit, whereas 29.3% originated from the sinuses. In the pediatric population under the age of 14 years, a total of 102 cases were identified. Out of these, there were 67 cases of orbito-cranial communication (65.7%), 5 cases of orbito-nasal communication (4.9%), and 30 cases of orbito-crano-nasal communication (29.4%). Optic glioma was the most common benign tumor in pediatric orbito-cranial communication (22.4%, 15/67), with an average age of onset at 5.6 ± 4.2 years. The most prevalent malignant tumor among children with orbito-cranial communication was small round cell tumor (10.4%, 7/67), with an average age of onset at 4.6 ± 3.7 years. In children with orbital-cranio-nasal communication, sarcoma was identified as the most common malignant tumor (43.3%, 13/30), with 76.9% of tumors originating from the nose. The most common benign tumor in this group was nasopharyngeal fibroangioma (16.7%, 5/30), which exclusively affected males and originated from the nasopharynx. Conclusion The clinical features and pathological classification of primary orbital tumors vary significantly depending on the type of communication. Moreover, there are substantial differences in the pathological subtypes of these orbital lesions between children and adults.https://doi.org/10.1186/s12886-025-04118-4Orbital, cranial, nasal tumorsCommunicationClinical featuresPathology |
| spellingShingle | Lian Wang Jing Zhang Shuo Zhang Bin Li Bentao Yang Hongjuan Liu Chunli Chen Qiong Wu Libin Jiang Research on the clinical and pathological characteristics of primary orbital neoplastic lesions with communication BMC Ophthalmology Orbital, cranial, nasal tumors Communication Clinical features Pathology |
| title | Research on the clinical and pathological characteristics of primary orbital neoplastic lesions with communication |
| title_full | Research on the clinical and pathological characteristics of primary orbital neoplastic lesions with communication |
| title_fullStr | Research on the clinical and pathological characteristics of primary orbital neoplastic lesions with communication |
| title_full_unstemmed | Research on the clinical and pathological characteristics of primary orbital neoplastic lesions with communication |
| title_short | Research on the clinical and pathological characteristics of primary orbital neoplastic lesions with communication |
| title_sort | research on the clinical and pathological characteristics of primary orbital neoplastic lesions with communication |
| topic | Orbital, cranial, nasal tumors Communication Clinical features Pathology |
| url | https://doi.org/10.1186/s12886-025-04118-4 |
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