Exosome-based approaches in cancer along with unlocking new insights into regeneration of cancer-prone tissues
Most eukaryotic cells secrete extracellular vesicles called exosomes, which are involved in intercellular communication. Exosomes play a role in tumor development and metastasis by transporting bioactive chemicals from cancerous cells to other cells in local and distant microenvironments. However, t...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Regenerative Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352320425000598 |
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| author | Mohsen Safaei Seyedeh Somayeh Rajabi Mahtab Tirgar Najmeh Namdar Mahsa Dalfardi Farnia Mohammadifar Arash Goodarzi Ahmad Reza Farmani Vahid Ramezani Zahra Abpeikar |
| author_facet | Mohsen Safaei Seyedeh Somayeh Rajabi Mahtab Tirgar Najmeh Namdar Mahsa Dalfardi Farnia Mohammadifar Arash Goodarzi Ahmad Reza Farmani Vahid Ramezani Zahra Abpeikar |
| author_sort | Mohsen Safaei |
| collection | DOAJ |
| description | Most eukaryotic cells secrete extracellular vesicles called exosomes, which are involved in intercellular communication. Exosomes play a role in tumor development and metastasis by transporting bioactive chemicals from cancerous cells to other cells in local and distant microenvironments. However, the potential of exosomes can be used by engineering them and considering different therapeutic approaches to overcome tumors. Exosomes are a promising drug delivery approach that can help decrease side effects from traditional treatments like radiation and chemotherapy by acting as targeted agents at the tumor site. The present review provides an overview of exosomes and various aspects of the role of exosomes in cancer development, which include these items: exosomes in cancer diagnosis, exosomes and drug delivery, exosomes and drug resistance, exosomal microRNAs and exosomes in tumor microenvironment, etc. Cancer stem cells release exosomes that nurture tumors, promoting unwanted growth and regeneration, and these types of exosomes should be inhibited. Ironically, exosomes from other cells, such as hepatocytes or mesenchymal stem cells (MSCs), are vital for healing organs like the liver and repairing gastric ulcers. Without proper treatment, this healing process can backfire, potentially leading to disease progression or even cancer. What can be found from various studies about the role of exosomes in the field of cancer is that exosomes act like a double-edged sword; on the other hand, natural exosomes in the body may play an important role in the process and progression of cancer, but by engineering exosomes, they can be directed towards target therapy and targeted delivery of drugs to tumor cells. By examining the role and application of exosomes in various mechanisms of cancer, it is possible to help treat this disease more efficiently and quickly in preclinical and clinical research. |
| format | Article |
| id | doaj-art-fe87af7bd8ff4db7ad8a3a379396d02d |
| institution | DOAJ |
| issn | 2352-3204 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Regenerative Therapy |
| spelling | doaj-art-fe87af7bd8ff4db7ad8a3a379396d02d2025-08-20T03:09:41ZengElsevierRegenerative Therapy2352-32042025-06-012920221610.1016/j.reth.2025.03.005Exosome-based approaches in cancer along with unlocking new insights into regeneration of cancer-prone tissuesMohsen Safaei0Seyedeh Somayeh Rajabi1Mahtab Tirgar2Najmeh Namdar3Mahsa Dalfardi4Farnia Mohammadifar5Arash Goodarzi6Ahmad Reza Farmani7Vahid Ramezani8Zahra Abpeikar9Department of Tissue Engineering, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, IranDepartment of Tissue Engineering, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, IranDepartment of Tissue Engineering, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, IranDepartment of Tissue Engineering, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, IranDepartment of Tissue Engineering, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, IranDepartment of Tissue Engineering, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, IranDepartment of Tissue Engineering, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, IranDepartment of Tissue Engineering, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, IranDepartment of Pharmaceutics, School of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, IranDepartment of Tissue Engineering, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, Iran; Corresponding author.Most eukaryotic cells secrete extracellular vesicles called exosomes, which are involved in intercellular communication. Exosomes play a role in tumor development and metastasis by transporting bioactive chemicals from cancerous cells to other cells in local and distant microenvironments. However, the potential of exosomes can be used by engineering them and considering different therapeutic approaches to overcome tumors. Exosomes are a promising drug delivery approach that can help decrease side effects from traditional treatments like radiation and chemotherapy by acting as targeted agents at the tumor site. The present review provides an overview of exosomes and various aspects of the role of exosomes in cancer development, which include these items: exosomes in cancer diagnosis, exosomes and drug delivery, exosomes and drug resistance, exosomal microRNAs and exosomes in tumor microenvironment, etc. Cancer stem cells release exosomes that nurture tumors, promoting unwanted growth and regeneration, and these types of exosomes should be inhibited. Ironically, exosomes from other cells, such as hepatocytes or mesenchymal stem cells (MSCs), are vital for healing organs like the liver and repairing gastric ulcers. Without proper treatment, this healing process can backfire, potentially leading to disease progression or even cancer. What can be found from various studies about the role of exosomes in the field of cancer is that exosomes act like a double-edged sword; on the other hand, natural exosomes in the body may play an important role in the process and progression of cancer, but by engineering exosomes, they can be directed towards target therapy and targeted delivery of drugs to tumor cells. By examining the role and application of exosomes in various mechanisms of cancer, it is possible to help treat this disease more efficiently and quickly in preclinical and clinical research.http://www.sciencedirect.com/science/article/pii/S2352320425000598CancerExosomeDrug deliveryDiagnosisExosomal microRNAsTumor microenvironment |
| spellingShingle | Mohsen Safaei Seyedeh Somayeh Rajabi Mahtab Tirgar Najmeh Namdar Mahsa Dalfardi Farnia Mohammadifar Arash Goodarzi Ahmad Reza Farmani Vahid Ramezani Zahra Abpeikar Exosome-based approaches in cancer along with unlocking new insights into regeneration of cancer-prone tissues Regenerative Therapy Cancer Exosome Drug delivery Diagnosis Exosomal microRNAs Tumor microenvironment |
| title | Exosome-based approaches in cancer along with unlocking new insights into regeneration of cancer-prone tissues |
| title_full | Exosome-based approaches in cancer along with unlocking new insights into regeneration of cancer-prone tissues |
| title_fullStr | Exosome-based approaches in cancer along with unlocking new insights into regeneration of cancer-prone tissues |
| title_full_unstemmed | Exosome-based approaches in cancer along with unlocking new insights into regeneration of cancer-prone tissues |
| title_short | Exosome-based approaches in cancer along with unlocking new insights into regeneration of cancer-prone tissues |
| title_sort | exosome based approaches in cancer along with unlocking new insights into regeneration of cancer prone tissues |
| topic | Cancer Exosome Drug delivery Diagnosis Exosomal microRNAs Tumor microenvironment |
| url | http://www.sciencedirect.com/science/article/pii/S2352320425000598 |
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