Effectiveness of cocoon strategy vaccination on prevention of influenza-like illness in young infants
During the initial half-year of their existence, infants cannot receive the influenza vaccine, yet they face the greatest susceptibility to severe influenza complications. In this study, we seek to determine whether influenza vaccination of maternal and household contacts is associated with a reduce...
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| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Human Vaccines & Immunotherapeutics |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21645515.2024.2350090 |
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| author | Melahat Melek Oguz Saliha Senel |
| author_facet | Melahat Melek Oguz Saliha Senel |
| author_sort | Melahat Melek Oguz |
| collection | DOAJ |
| description | During the initial half-year of their existence, infants cannot receive the influenza vaccine, yet they face the greatest susceptibility to severe influenza complications. In this study, we seek to determine whether influenza vaccination of maternal and household contacts is associated with a reduced risk of influenza-like illness (ILI) and severe acute respiratory infection (SARI) in infants. This work was prospectively conducted during the influenza season. A total of 206 infants were included in this study. The percentage of infants with only the mother vaccinated is 12.6% (n:26), and the percent of infants with all household contacts vaccinated is 16% (n:33). Among the infants with only the mother vaccinated, the effectiveness of influenza vaccine is estimated as 35.3% for ILI and 41.3% for SARI. Among infants with all household contacts vaccinated, the effectiveness is estimated as 48.9% for ILI and 76.9% for SARI. Based on the results of multivariate logistic regression analysis, all-household vaccination is a protective factor against SARI (OR: 0.07 95% CI [0.01–0.56]), household size (OR: 1.75, 95% CI [1.24–2.48]) and presence of secondhand smoke (OR: 2.2, 95% CI [1.12–4.45]) significant risk factors for SARI in infants. The mother alone being vaccinated is not a statistically significant protective factor against ILI (OR: 0.46, 95% CI [0.19–1.18]) or SARI (OR: 0.3, 95% CI [0.11–1.21]). Along with the obtained results and analysis, this study provides clear evidence that influenza vaccination of all household contacts of infants aged 0–6 months is significantly associated with protecting infants from both ILI and SARI. |
| format | Article |
| id | doaj-art-fe7a617128284b44a9d3a6bd43d1dc18 |
| institution | DOAJ |
| issn | 2164-5515 2164-554X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj-art-fe7a617128284b44a9d3a6bd43d1dc182025-08-20T03:12:43ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2024-12-0120110.1080/21645515.2024.2350090Effectiveness of cocoon strategy vaccination on prevention of influenza-like illness in young infantsMelahat Melek Oguz0Saliha Senel1Department of Pediatrics, Dr. Sami Ulus Maternity and Children’s Health and Diseases Training and Research Hospital, University of Health Sciences, Ankara, TurkeyDepartment of Pediatrics, Yildirim Beyazit University, Ankara, TurkeyDuring the initial half-year of their existence, infants cannot receive the influenza vaccine, yet they face the greatest susceptibility to severe influenza complications. In this study, we seek to determine whether influenza vaccination of maternal and household contacts is associated with a reduced risk of influenza-like illness (ILI) and severe acute respiratory infection (SARI) in infants. This work was prospectively conducted during the influenza season. A total of 206 infants were included in this study. The percentage of infants with only the mother vaccinated is 12.6% (n:26), and the percent of infants with all household contacts vaccinated is 16% (n:33). Among the infants with only the mother vaccinated, the effectiveness of influenza vaccine is estimated as 35.3% for ILI and 41.3% for SARI. Among infants with all household contacts vaccinated, the effectiveness is estimated as 48.9% for ILI and 76.9% for SARI. Based on the results of multivariate logistic regression analysis, all-household vaccination is a protective factor against SARI (OR: 0.07 95% CI [0.01–0.56]), household size (OR: 1.75, 95% CI [1.24–2.48]) and presence of secondhand smoke (OR: 2.2, 95% CI [1.12–4.45]) significant risk factors for SARI in infants. The mother alone being vaccinated is not a statistically significant protective factor against ILI (OR: 0.46, 95% CI [0.19–1.18]) or SARI (OR: 0.3, 95% CI [0.11–1.21]). Along with the obtained results and analysis, this study provides clear evidence that influenza vaccination of all household contacts of infants aged 0–6 months is significantly associated with protecting infants from both ILI and SARI.https://www.tandfonline.com/doi/10.1080/21645515.2024.2350090Cocooninginfluenzainfluenza-like illnesssevere acute respiratory infection |
| spellingShingle | Melahat Melek Oguz Saliha Senel Effectiveness of cocoon strategy vaccination on prevention of influenza-like illness in young infants Human Vaccines & Immunotherapeutics Cocooning influenza influenza-like illness severe acute respiratory infection |
| title | Effectiveness of cocoon strategy vaccination on prevention of influenza-like illness in young infants |
| title_full | Effectiveness of cocoon strategy vaccination on prevention of influenza-like illness in young infants |
| title_fullStr | Effectiveness of cocoon strategy vaccination on prevention of influenza-like illness in young infants |
| title_full_unstemmed | Effectiveness of cocoon strategy vaccination on prevention of influenza-like illness in young infants |
| title_short | Effectiveness of cocoon strategy vaccination on prevention of influenza-like illness in young infants |
| title_sort | effectiveness of cocoon strategy vaccination on prevention of influenza like illness in young infants |
| topic | Cocooning influenza influenza-like illness severe acute respiratory infection |
| url | https://www.tandfonline.com/doi/10.1080/21645515.2024.2350090 |
| work_keys_str_mv | AT melahatmelekoguz effectivenessofcocoonstrategyvaccinationonpreventionofinfluenzalikeillnessinyounginfants AT salihasenel effectivenessofcocoonstrategyvaccinationonpreventionofinfluenzalikeillnessinyounginfants |