Amyloid is associated with accelerated atrophy in cognitively unimpaired individuals

Amyloid is associated with accelerated atrophy in cognitively unimpaired individuals

Abstract INTRODUCTION This study examined the association of longitudinal atrophy with baseline cerebrospinal fluid (CSF) amyloid beta (Aβ, A) and phosphorylated tau (p‐tau, T) biomarkers (Aβ42/40, p‐tau181) in 406 cognitively unimpaired (CU) individuals (6.670 years of follow‐up on average, up to 1...

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Main Authors: Henry Gilreath Stephenson, Tobey J. Betthauser, Rebecca Langhough, Erin Jonaitis, Lianlian Du, Carol Van Hulle, Gwendlyn Kollmorgen, Clara Quijano‐Rubio, Nathaniel A. Chin, Ozioma C. Okonkwo, Cynthia M. Carlsson, Sanjay Asthana, Sterling C. Johnson, Kaj Blennow, Henrik Zetterberg, Barbara B. Bendlin
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
Subjects:
AD
amyloid beta
atrophy
CSF biomarkers
MRI
phosphorylated tau
Online Access:https://doi.org/10.1002/dad2.70089
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