Managing Inflammation after Spinal Cord Injury through Manipulation of Macrophage Function
Spinal cord injury (SCI) triggers inflammation with activation of innate immune responses that contribute to secondary injury including oligodendrocyte apoptosis, demyelination, axonal degeneration, and neuronal death. Macrophage activation, accumulation, and persistent inflammation occur in SCI. Ma...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2013/945034 |
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| author | Yi Ren Wise Young |
| author_facet | Yi Ren Wise Young |
| author_sort | Yi Ren |
| collection | DOAJ |
| description | Spinal cord injury (SCI) triggers inflammation with activation of innate immune responses that contribute to secondary injury including oligodendrocyte apoptosis, demyelination, axonal degeneration, and neuronal death. Macrophage activation, accumulation, and persistent inflammation occur in SCI. Macrophages are heterogeneous cells with extensive functional plasticity and have the capacity to switch phenotypes by factors present in the inflammatory microenvironment of the injured spinal cord. This review will discuss the role of different polarized macrophages and the potential effect of macrophage-based therapies for SCI. |
| format | Article |
| id | doaj-art-fe74c063a4e147b89a01767f3ac183e3 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-fe74c063a4e147b89a01767f3ac183e32025-08-20T03:25:46ZengWileyNeural Plasticity2090-59041687-54432013-01-01201310.1155/2013/945034945034Managing Inflammation after Spinal Cord Injury through Manipulation of Macrophage FunctionYi Ren0Wise Young1Department of Biomedical Sciences, College of Medicine, Florida State University, 1115 West Call Street, Tallahassee, FL 32306-4300, USAW. M. Keck Center for Collaborative Neuroscience, Rutgers, The State University of New Jersey, Nelson Labs D-251, 604 Allison Road, Piscataway, NJ 08854, USASpinal cord injury (SCI) triggers inflammation with activation of innate immune responses that contribute to secondary injury including oligodendrocyte apoptosis, demyelination, axonal degeneration, and neuronal death. Macrophage activation, accumulation, and persistent inflammation occur in SCI. Macrophages are heterogeneous cells with extensive functional plasticity and have the capacity to switch phenotypes by factors present in the inflammatory microenvironment of the injured spinal cord. This review will discuss the role of different polarized macrophages and the potential effect of macrophage-based therapies for SCI.http://dx.doi.org/10.1155/2013/945034 |
| spellingShingle | Yi Ren Wise Young Managing Inflammation after Spinal Cord Injury through Manipulation of Macrophage Function Neural Plasticity |
| title | Managing Inflammation after Spinal Cord Injury through Manipulation of Macrophage Function |
| title_full | Managing Inflammation after Spinal Cord Injury through Manipulation of Macrophage Function |
| title_fullStr | Managing Inflammation after Spinal Cord Injury through Manipulation of Macrophage Function |
| title_full_unstemmed | Managing Inflammation after Spinal Cord Injury through Manipulation of Macrophage Function |
| title_short | Managing Inflammation after Spinal Cord Injury through Manipulation of Macrophage Function |
| title_sort | managing inflammation after spinal cord injury through manipulation of macrophage function |
| url | http://dx.doi.org/10.1155/2013/945034 |
| work_keys_str_mv | AT yiren managinginflammationafterspinalcordinjurythroughmanipulationofmacrophagefunction AT wiseyoung managinginflammationafterspinalcordinjurythroughmanipulationofmacrophagefunction |