Targeting GDF15 to enhance immunotherapy efficacy in glioblastoma through tumor microenvironment-responsive CRISPR-Cas9 nanoparticles

Targeting GDF15 to enhance immunotherapy efficacy in glioblastoma through tumor microenvironment-responsive CRISPR-Cas9 nanoparticles

Abstract Despite the outstanding clinical success of immunotherapy, its therapeutic efficacy in glioblastoma (GBM) is still limited. To identify critical regulators of GBM immunity, we constructed a mouse single-guide RNA (sgRNA) library corresponding to all disease-related immune genes, and perform...

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Bibliographic Details
Main Authors: Cheng Zou, Xiao Liu, Weizhong Wang, Lei He, Anan Yin, Zhengcong Cao, Maorong Zhu, Yuxin Wu, Xiaolin Liu, Jiying Ma, Yalong He, Shuning Wang, Wangqian Zhang, Wei Liu, Yingqi Zhang, Jintao Gu, Wei Lin, Kuo Zhang, Meng Li
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Journal of Nanobiotechnology
Online Access:https://doi.org/10.1186/s12951-025-03182-8
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