Pneumococcal disease: emergence of serotypes 19A and 7F following conjugate pneumococcal vaccination in a Mexican hospital
Introduction: Mexico was the first country to initiate massive vaccination with heptavalent pneumococcal conjugate vaccine (PCV-7) in children. There is no information regarding pneumococcal invasive disease (PID) in children before and after implementation of PCV-...
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The Journal of Infection in Developing Countries
2011-12-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/1954 |
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| author | Enrique Chacon-Cruz Yazbeck Velazco-Mendez Samuel Navarro-Alvarez Rosa Maria Rivas-Landeros Maria Luisa Volker Graciano Lopez-Espinoza |
| author_facet | Enrique Chacon-Cruz Yazbeck Velazco-Mendez Samuel Navarro-Alvarez Rosa Maria Rivas-Landeros Maria Luisa Volker Graciano Lopez-Espinoza |
| author_sort | Enrique Chacon-Cruz |
| collection | DOAJ |
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Introduction: Mexico was the first country to initiate massive vaccination with heptavalent pneumococcal conjugate vaccine (PCV-7) in children. There is no information regarding pneumococcal invasive disease (PID) in children before and after implementation of PCV-7 in Mexico or elsewhere in Latin America.
Methodology: During October 2005 to September 2010, active surveillance for pediatric PID was initiated at Tijuana General Hospital. Only culture-confirmed cases from sterile fluids were included in the study. Serotype identification was also performed.
Results: Twenty-eight pediatric PID cases were confirmed. Streptococcus pneumoniae was the main cause of pleural empyema (n = 13). It was also the second most common cause of confirmed bacterial meningitis (n = 10), followed by Neisseria meningitidis (n = ?), and the only cause of otomastoiditis with bacterial isolation (n = 5). Vaccine-associated serotypes decreased from 54% before PCV-7 introduction to the vaccination schedule, to only 5.6% after PCV-7 implementation. Serotypes 19A and 7F (47% and 33% respectively) were predominant following PCV-7 vaccination.
Conclusions: Serotype substitution in PID is present in the northern border of Mexico following PCV-7 vaccination in children.
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| format | Article |
| id | doaj-art-fe71f23e24204b2f9907e7c5d6250a34 |
| institution | OA Journals |
| issn | 1972-2680 |
| language | English |
| publishDate | 2011-12-01 |
| publisher | The Journal of Infection in Developing Countries |
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| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-fe71f23e24204b2f9907e7c5d6250a342025-08-20T02:16:06ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802011-12-0160610.3855/jidc.1954Pneumococcal disease: emergence of serotypes 19A and 7F following conjugate pneumococcal vaccination in a Mexican hospitalEnrique Chacon-Cruz0Yazbeck Velazco-Mendez1Samuel Navarro-Alvarez2Rosa Maria Rivas-Landeros3Maria Luisa Volker4Graciano Lopez-Espinoza5General Hospital of Tijuana, MexicoGeneral Hospital of Tijuana, MexicoGeneral Hospital of Tijuana, MexicoGeneral Hospital of Tijuana, MexicoGeneral Hospital of Tijuana, MexicoGeneral Hospital of Tijuana, Mexico Introduction: Mexico was the first country to initiate massive vaccination with heptavalent pneumococcal conjugate vaccine (PCV-7) in children. There is no information regarding pneumococcal invasive disease (PID) in children before and after implementation of PCV-7 in Mexico or elsewhere in Latin America. Methodology: During October 2005 to September 2010, active surveillance for pediatric PID was initiated at Tijuana General Hospital. Only culture-confirmed cases from sterile fluids were included in the study. Serotype identification was also performed. Results: Twenty-eight pediatric PID cases were confirmed. Streptococcus pneumoniae was the main cause of pleural empyema (n = 13). It was also the second most common cause of confirmed bacterial meningitis (n = 10), followed by Neisseria meningitidis (n = ?), and the only cause of otomastoiditis with bacterial isolation (n = 5). Vaccine-associated serotypes decreased from 54% before PCV-7 introduction to the vaccination schedule, to only 5.6% after PCV-7 implementation. Serotypes 19A and 7F (47% and 33% respectively) were predominant following PCV-7 vaccination. Conclusions: Serotype substitution in PID is present in the northern border of Mexico following PCV-7 vaccination in children. https://jidc.org/index.php/journal/article/view/1954Streptococcus pneumoniaepneumococcal invasive diseasepneumococcal conjugate vaccinesserotypes 19A and 7FMexico |
| spellingShingle | Enrique Chacon-Cruz Yazbeck Velazco-Mendez Samuel Navarro-Alvarez Rosa Maria Rivas-Landeros Maria Luisa Volker Graciano Lopez-Espinoza Pneumococcal disease: emergence of serotypes 19A and 7F following conjugate pneumococcal vaccination in a Mexican hospital Journal of Infection in Developing Countries Streptococcus pneumoniae pneumococcal invasive disease pneumococcal conjugate vaccines serotypes 19A and 7F Mexico |
| title | Pneumococcal disease: emergence of serotypes 19A and 7F following conjugate pneumococcal vaccination in a Mexican hospital |
| title_full | Pneumococcal disease: emergence of serotypes 19A and 7F following conjugate pneumococcal vaccination in a Mexican hospital |
| title_fullStr | Pneumococcal disease: emergence of serotypes 19A and 7F following conjugate pneumococcal vaccination in a Mexican hospital |
| title_full_unstemmed | Pneumococcal disease: emergence of serotypes 19A and 7F following conjugate pneumococcal vaccination in a Mexican hospital |
| title_short | Pneumococcal disease: emergence of serotypes 19A and 7F following conjugate pneumococcal vaccination in a Mexican hospital |
| title_sort | pneumococcal disease emergence of serotypes 19a and 7f following conjugate pneumococcal vaccination in a mexican hospital |
| topic | Streptococcus pneumoniae pneumococcal invasive disease pneumococcal conjugate vaccines serotypes 19A and 7F Mexico |
| url | https://jidc.org/index.php/journal/article/view/1954 |
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