Dual functional hydrogel of osteoclastic-inhibition and osteogenic-stimulation for osteoporotic bone defect regeneration
Osteoporotic bone regeneration poses significant challenges due to the complexity of the condition. Osteoporosis, a degenerative disorder, results from an imbalance in bone homeostasis driven by dysregulation of osteoblast and osteoclast activity. This complicates the treatment of osteoporosis and i...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-04-01
|
| Series: | Materials Today Bio |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425001085 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823859441829675008 |
|---|---|
| author | Lei Yu Wentao Wang Chang Lv Qian Chen Peng Yang Zhenrong Qi Haomiao Yu Ruiqi Cao Wenhao Li Yi Qin Gaoran Ge Peilai Liu Lixin Zhu Houyi Sun Dechun Geng Liang Zhang |
| author_facet | Lei Yu Wentao Wang Chang Lv Qian Chen Peng Yang Zhenrong Qi Haomiao Yu Ruiqi Cao Wenhao Li Yi Qin Gaoran Ge Peilai Liu Lixin Zhu Houyi Sun Dechun Geng Liang Zhang |
| author_sort | Lei Yu |
| collection | DOAJ |
| description | Osteoporotic bone regeneration poses significant challenges due to the complexity of the condition. Osteoporosis, a degenerative disorder, results from an imbalance in bone homeostasis driven by dysregulation of osteoblast and osteoclast activity. This complicates the treatment of osteoporosis and its related bone injuries in clinical practice. Despite the development of various polymer scaffolds for bone defect repair, achieving effective regeneration in osteoporotic bones—especially when combined with osteoporosis medications—remains difficult. In this study, we designed a drug delivery system composed of mesoporous bioactive glass (MBG) and photo-crosslinked hyaluronic acid methacrylate (HAMA). This system, loaded with the osteogenesis-promoting peptide DWIVA (D5) and the osteoclastogenesis-inhibiting drug alendronate (ALN), is gelled using a light initiator and 405 nm wavelength light. The MBG@D5-Gel complex enables the controlled spatiotemporal release of these agents, markedly enhancing bone regeneration in osteoporotic conditions within ovariectomized rats by inhibiting osteoclastogenesis and bone resorption while promoting osteogenic differentiation and mineralization. This dual-action system synergistically regulates osteoblast and osteoclast activity, optimizing the pathological microenvironment of osteoporosis and facilitating the repair of osteoporotic bone defects. MBG@D5-Gel holds great potential as an effective organic-inorganic hybrid biomimetic implant material for the treatment of osteoporotic bone defects. |
| format | Article |
| id | doaj-art-fe71bfdcc112451b8230f11fddab4d01 |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-fe71bfdcc112451b8230f11fddab4d012025-02-11T04:35:22ZengElsevierMaterials Today Bio2590-00642025-04-0131101550Dual functional hydrogel of osteoclastic-inhibition and osteogenic-stimulation for osteoporotic bone defect regenerationLei Yu0Wentao Wang1Chang Lv2Qian Chen3Peng Yang4Zhenrong Qi5Haomiao Yu6Ruiqi Cao7Wenhao Li8Yi Qin9Gaoran Ge10Peilai Liu11Lixin Zhu12Houyi Sun13Dechun Geng14Liang Zhang15Department of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute, Medical College, Soochow University, Suzhou, 215006, Jiangsu, China; Department of Orthopedics, Qilu Hospital of Shangdong University, Shandong University, Jinan, 250100, Shandong, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute, Medical College, Soochow University, Suzhou, 215006, Jiangsu, ChinaDepartment of Spinal Surgery, Orthopedic Medical Center, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, Guangdong, ChinaDepartment of Orthopedics, Beijing Friendship Hospital, Capital Medical University, 95 Yongan Road, Xicheng District, Beijing, 100050, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute, Medical College, Soochow University, Suzhou, 215006, Jiangsu, ChinaDepartment of Orthopedics, Beijing Friendship Hospital, Capital Medical University, 95 Yongan Road, Xicheng District, Beijing, 100050, ChinaDepartment of Orthopedics, Beijing Friendship Hospital, Capital Medical University, 95 Yongan Road, Xicheng District, Beijing, 100050, ChinaDepartment of Orthopedics, Beijing Friendship Hospital, Capital Medical University, 95 Yongan Road, Xicheng District, Beijing, 100050, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute, Medical College, Soochow University, Suzhou, 215006, Jiangsu, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute, Medical College, Soochow University, Suzhou, 215006, Jiangsu, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute, Medical College, Soochow University, Suzhou, 215006, Jiangsu, ChinaDepartment of Orthopedics, Qilu Hospital of Shangdong University, Shandong University, Jinan, 250100, Shandong, ChinaDepartment of Spinal Surgery, Orthopedic Medical Center, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, Guangdong, ChinaDepartment of Orthopedics, Qilu Hospital of Shangdong University, Shandong University, Jinan, 250100, Shandong, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute, Medical College, Soochow University, Suzhou, 215006, Jiangsu, ChinaDepartment of Orthopedics, Beijing Friendship Hospital, Capital Medical University, 95 Yongan Road, Xicheng District, Beijing, 100050, China; Corresponding author.Osteoporotic bone regeneration poses significant challenges due to the complexity of the condition. Osteoporosis, a degenerative disorder, results from an imbalance in bone homeostasis driven by dysregulation of osteoblast and osteoclast activity. This complicates the treatment of osteoporosis and its related bone injuries in clinical practice. Despite the development of various polymer scaffolds for bone defect repair, achieving effective regeneration in osteoporotic bones—especially when combined with osteoporosis medications—remains difficult. In this study, we designed a drug delivery system composed of mesoporous bioactive glass (MBG) and photo-crosslinked hyaluronic acid methacrylate (HAMA). This system, loaded with the osteogenesis-promoting peptide DWIVA (D5) and the osteoclastogenesis-inhibiting drug alendronate (ALN), is gelled using a light initiator and 405 nm wavelength light. The MBG@D5-Gel complex enables the controlled spatiotemporal release of these agents, markedly enhancing bone regeneration in osteoporotic conditions within ovariectomized rats by inhibiting osteoclastogenesis and bone resorption while promoting osteogenic differentiation and mineralization. This dual-action system synergistically regulates osteoblast and osteoclast activity, optimizing the pathological microenvironment of osteoporosis and facilitating the repair of osteoporotic bone defects. MBG@D5-Gel holds great potential as an effective organic-inorganic hybrid biomimetic implant material for the treatment of osteoporotic bone defects.http://www.sciencedirect.com/science/article/pii/S2590006425001085OsteoporosisHydrogelAlendronateOsteoclastic differentiationOsteogenic differentiationBone regeneration |
| spellingShingle | Lei Yu Wentao Wang Chang Lv Qian Chen Peng Yang Zhenrong Qi Haomiao Yu Ruiqi Cao Wenhao Li Yi Qin Gaoran Ge Peilai Liu Lixin Zhu Houyi Sun Dechun Geng Liang Zhang Dual functional hydrogel of osteoclastic-inhibition and osteogenic-stimulation for osteoporotic bone defect regeneration Materials Today Bio Osteoporosis Hydrogel Alendronate Osteoclastic differentiation Osteogenic differentiation Bone regeneration |
| title | Dual functional hydrogel of osteoclastic-inhibition and osteogenic-stimulation for osteoporotic bone defect regeneration |
| title_full | Dual functional hydrogel of osteoclastic-inhibition and osteogenic-stimulation for osteoporotic bone defect regeneration |
| title_fullStr | Dual functional hydrogel of osteoclastic-inhibition and osteogenic-stimulation for osteoporotic bone defect regeneration |
| title_full_unstemmed | Dual functional hydrogel of osteoclastic-inhibition and osteogenic-stimulation for osteoporotic bone defect regeneration |
| title_short | Dual functional hydrogel of osteoclastic-inhibition and osteogenic-stimulation for osteoporotic bone defect regeneration |
| title_sort | dual functional hydrogel of osteoclastic inhibition and osteogenic stimulation for osteoporotic bone defect regeneration |
| topic | Osteoporosis Hydrogel Alendronate Osteoclastic differentiation Osteogenic differentiation Bone regeneration |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425001085 |
| work_keys_str_mv | AT leiyu dualfunctionalhydrogelofosteoclasticinhibitionandosteogenicstimulationforosteoporoticbonedefectregeneration AT wentaowang dualfunctionalhydrogelofosteoclasticinhibitionandosteogenicstimulationforosteoporoticbonedefectregeneration AT changlv dualfunctionalhydrogelofosteoclasticinhibitionandosteogenicstimulationforosteoporoticbonedefectregeneration AT qianchen dualfunctionalhydrogelofosteoclasticinhibitionandosteogenicstimulationforosteoporoticbonedefectregeneration AT pengyang dualfunctionalhydrogelofosteoclasticinhibitionandosteogenicstimulationforosteoporoticbonedefectregeneration AT zhenrongqi dualfunctionalhydrogelofosteoclasticinhibitionandosteogenicstimulationforosteoporoticbonedefectregeneration AT haomiaoyu dualfunctionalhydrogelofosteoclasticinhibitionandosteogenicstimulationforosteoporoticbonedefectregeneration AT ruiqicao dualfunctionalhydrogelofosteoclasticinhibitionandosteogenicstimulationforosteoporoticbonedefectregeneration AT wenhaoli dualfunctionalhydrogelofosteoclasticinhibitionandosteogenicstimulationforosteoporoticbonedefectregeneration AT yiqin dualfunctionalhydrogelofosteoclasticinhibitionandosteogenicstimulationforosteoporoticbonedefectregeneration AT gaorange dualfunctionalhydrogelofosteoclasticinhibitionandosteogenicstimulationforosteoporoticbonedefectregeneration AT peilailiu dualfunctionalhydrogelofosteoclasticinhibitionandosteogenicstimulationforosteoporoticbonedefectregeneration AT lixinzhu dualfunctionalhydrogelofosteoclasticinhibitionandosteogenicstimulationforosteoporoticbonedefectregeneration AT houyisun dualfunctionalhydrogelofosteoclasticinhibitionandosteogenicstimulationforosteoporoticbonedefectregeneration AT dechungeng dualfunctionalhydrogelofosteoclasticinhibitionandosteogenicstimulationforosteoporoticbonedefectregeneration AT liangzhang dualfunctionalhydrogelofosteoclasticinhibitionandosteogenicstimulationforosteoporoticbonedefectregeneration |