The impact of serum testosterone level to reflect age-related multi-organ functions
The aim of this study is to examine the correlation between aging, serum total testosterone and biomarkers of multiple organ functions in men. The participants consisted of 12,547 outpatients, whose serum testosterone level was measured. A multiple regression analysis was conducted to determine whet...
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| Format: | Article |
| Language: | English |
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The Japan Endocrine Society
2024-03-01
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| Series: | Endocrine Journal |
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| Online Access: | https://www.jstage.jst.go.jp/article/endocrj/71/3/71_EJ23-0380/_html/-char/en |
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| author | Tomoya Shirakawa Julius Fink Zen-u Hotta Yosuke Shimada Yan Lu Junhua Du Kazuhito Matsushita Satoshi Hori Hisamitsu Ide Shigeo Horie |
| author_facet | Tomoya Shirakawa Julius Fink Zen-u Hotta Yosuke Shimada Yan Lu Junhua Du Kazuhito Matsushita Satoshi Hori Hisamitsu Ide Shigeo Horie |
| author_sort | Tomoya Shirakawa |
| collection | DOAJ |
| description | The aim of this study is to examine the correlation between aging, serum total testosterone and biomarkers of multiple organ functions in men. The participants consisted of 12,547 outpatients, whose serum testosterone level was measured. A multiple regression analysis was conducted to determine whether biomarkers including hemoglobin (Hb), hematocrit (Hct), luteinizing hormone (LH), follicle stimulating hormone (FSH), alkaline phosphatase (ALP), albumin (ALB), creatinine (Cre), aspartate aminotransferase (AST), alanine aminotransferase (ALT), glucose (Glu), C-reactive protein (CRP), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) values were associated with serum total testosterone concentration. Significant correlations (p < 0.05) were found between total testosterone and Hb, Hct, LH, FSH, ALP, ALB, TG, HDL-C, AST, ALT, Glu, and CRP. In addition, significant correlations (p < 0.05) were found between Hb, Hct, LH, FSH, ALP, ALB, TG and HDL-C associated with [age × testosterone]. This large-scale study provided new insights into correlations between serum testosterone and biomarkers associated with age-related diseases, suggesting that testosterone is especially important for maintaining homeostasis in aging males. Thus, hypogonadism in elderly patients may be associated with multiple organ dysfunctions. |
| format | Article |
| id | doaj-art-fe68f080170b4af481e9b40353439881 |
| institution | Kabale University |
| issn | 1348-4540 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | The Japan Endocrine Society |
| record_format | Article |
| series | Endocrine Journal |
| spelling | doaj-art-fe68f080170b4af481e9b403534398812025-01-22T06:35:05ZengThe Japan Endocrine SocietyEndocrine Journal1348-45402024-03-0171326527210.1507/endocrj.EJ23-0380endocrjThe impact of serum testosterone level to reflect age-related multi-organ functionsTomoya Shirakawa0Julius Fink1Zen-u Hotta2Yosuke Shimada3Yan Lu4Junhua Du5Kazuhito Matsushita6Satoshi Hori7Hisamitsu Ide8Shigeo Horie9Department of Urology, Juntendo University, Graduate School of Medicine, Tokyo 113-8421, JapanDepartment of Urology, Juntendo University, Graduate School of Medicine, Tokyo 113-8421, JapanDepartment of Urology, Juntendo University, Graduate School of Medicine, Tokyo 113-8421, JapanDepartment of Infection Control Science, Juntendo University, Graduate School of Medicine, Tokyo 113-8421, JapanDepartment of Urology, Juntendo University, Graduate School of Medicine, Tokyo 113-8421, JapanDepartment of Urology, Juntendo University, Graduate School of Medicine, Tokyo 113-8421, JapanDepartment of Urology, Juntendo University, Graduate School of Medicine, Tokyo 113-8421, JapanDepartment of Infection Control Science, Juntendo University, Graduate School of Medicine, Tokyo 113-8421, JapanDepartment of Urology, Juntendo University, Graduate School of Medicine, Tokyo 113-8421, JapanDepartment of Urology, Juntendo University, Graduate School of Medicine, Tokyo 113-8421, JapanThe aim of this study is to examine the correlation between aging, serum total testosterone and biomarkers of multiple organ functions in men. The participants consisted of 12,547 outpatients, whose serum testosterone level was measured. A multiple regression analysis was conducted to determine whether biomarkers including hemoglobin (Hb), hematocrit (Hct), luteinizing hormone (LH), follicle stimulating hormone (FSH), alkaline phosphatase (ALP), albumin (ALB), creatinine (Cre), aspartate aminotransferase (AST), alanine aminotransferase (ALT), glucose (Glu), C-reactive protein (CRP), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) values were associated with serum total testosterone concentration. Significant correlations (p < 0.05) were found between total testosterone and Hb, Hct, LH, FSH, ALP, ALB, TG, HDL-C, AST, ALT, Glu, and CRP. In addition, significant correlations (p < 0.05) were found between Hb, Hct, LH, FSH, ALP, ALB, TG and HDL-C associated with [age × testosterone]. This large-scale study provided new insights into correlations between serum testosterone and biomarkers associated with age-related diseases, suggesting that testosterone is especially important for maintaining homeostasis in aging males. Thus, hypogonadism in elderly patients may be associated with multiple organ dysfunctions.https://www.jstage.jst.go.jp/article/endocrj/71/3/71_EJ23-0380/_html/-char/enagingbiomarkershomeostasislifestyle diseasetestosterone |
| spellingShingle | Tomoya Shirakawa Julius Fink Zen-u Hotta Yosuke Shimada Yan Lu Junhua Du Kazuhito Matsushita Satoshi Hori Hisamitsu Ide Shigeo Horie The impact of serum testosterone level to reflect age-related multi-organ functions Endocrine Journal aging biomarkers homeostasis lifestyle disease testosterone |
| title | The impact of serum testosterone level to reflect age-related multi-organ functions |
| title_full | The impact of serum testosterone level to reflect age-related multi-organ functions |
| title_fullStr | The impact of serum testosterone level to reflect age-related multi-organ functions |
| title_full_unstemmed | The impact of serum testosterone level to reflect age-related multi-organ functions |
| title_short | The impact of serum testosterone level to reflect age-related multi-organ functions |
| title_sort | impact of serum testosterone level to reflect age related multi organ functions |
| topic | aging biomarkers homeostasis lifestyle disease testosterone |
| url | https://www.jstage.jst.go.jp/article/endocrj/71/3/71_EJ23-0380/_html/-char/en |
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