An expanded polyglutamine in ATAXIN1 results in a loss-of-function that exacerbates severity of Multiple Sclerosis in an EAE mouse model

An expanded polyglutamine in ATAXIN1 results in a loss-of-function that exacerbates severity of Multiple Sclerosis in an EAE mouse model

Abstract Background and objectives Ataxin-1 (ATXN1) is a protein in which expansion of its polyglutamine tract causes the neurodegenerative disorder spinocerebellar ataxia type 1 (SCA1) via a gain-of-function. Wild type ATXN1 was recently shown to have a protective role in regulating severity of exp...

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Bibliographic Details
Main Authors: Gourango Talukdar, Lisa Duvick, Praseuth Yang, Brennon O’Callaghan, Gavin J. Fuchs, Marija Cvetanovic, Harry T. Orr
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Neuroinflammation
Subjects:
ATAXIN1
Multiple sclerosis
Autoimmune
Demyelination
EAE
SCA1
Online Access:https://doi.org/10.1186/s12974-025-03450-2
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