Plant Antimicrobial Compounds and Their Mechanisms of Action on Spoilage and Pathogenic Bacteria: A Bibliometric Study and Literature Review
This research explored the potential of plant antimicrobial compounds as natural alternatives to synthetic antimicrobials in the food and pharmaceutical industries, emphasizing the urgent need to combat antimicrobial resistance. It detailed various mechanisms by which these plant-derived compounds i...
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2025-03-01
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| author | Jesús Guadalupe Pérez-Flores Laura García-Curiel Emmanuel Pérez-Escalante Elizabeth Contreras-López Guadalupe Yoselín Aguilar-Lira Carlos Ángel-Jijón Luis Guillermo González-Olivares Elena Saraí Baena-Santillán Israel Oswaldo Ocampo-Salinas José Antonio Guerrero-Solano Lizbeth Anahí Portillo-Torres |
| author_facet | Jesús Guadalupe Pérez-Flores Laura García-Curiel Emmanuel Pérez-Escalante Elizabeth Contreras-López Guadalupe Yoselín Aguilar-Lira Carlos Ángel-Jijón Luis Guillermo González-Olivares Elena Saraí Baena-Santillán Israel Oswaldo Ocampo-Salinas José Antonio Guerrero-Solano Lizbeth Anahí Portillo-Torres |
| author_sort | Jesús Guadalupe Pérez-Flores |
| collection | DOAJ |
| description | This research explored the potential of plant antimicrobial compounds as natural alternatives to synthetic antimicrobials in the food and pharmaceutical industries, emphasizing the urgent need to combat antimicrobial resistance. It detailed various mechanisms by which these plant-derived compounds inhibit microbial growth, including disrupting cell membrane integrity, impeding cell wall and protein synthesis, and preventing biofilm formation, ultimately leading to bacterial cell death. This study highlighted the specific effects of plant antimicrobials on bacterial cells, such as inhibiting biofilm formation, cellular respiration, and cell motility, while also modulating oxygen consumption and reactive oxygen species generation, which are vital in addressing biofilm-mediated infections. Additionally, these compounds can regulate the expression of virulence factors and efflux pumps, enhancing antibiotic efficacy. A bibliometric analysis revealed a growing trend in research output and international collaboration, particularly from China and the United States, with key journals including “Frontiers in Microbiology” and “Antimicrobial Agents and Chemotherapy.” The analysis identified six clusters related to plant antimicrobial research, underscoring the need for further investigation into the mechanisms and applications of these bioactive compounds. In conclusion, understanding the action of plant antimicrobials is important for their effective application in combating antimicrobial resistance. |
| format | Article |
| id | doaj-art-fe5aa35c3d3044478cf2d1cb06e0ea02 |
| institution | DOAJ |
| issn | 2076-3417 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj-art-fe5aa35c3d3044478cf2d1cb06e0ea022025-08-20T03:06:20ZengMDPI AGApplied Sciences2076-34172025-03-01157351610.3390/app15073516Plant Antimicrobial Compounds and Their Mechanisms of Action on Spoilage and Pathogenic Bacteria: A Bibliometric Study and Literature ReviewJesús Guadalupe Pérez-Flores0Laura García-Curiel1Emmanuel Pérez-Escalante2Elizabeth Contreras-López3Guadalupe Yoselín Aguilar-Lira4Carlos Ángel-Jijón5Luis Guillermo González-Olivares6Elena Saraí Baena-Santillán7Israel Oswaldo Ocampo-Salinas8José Antonio Guerrero-Solano9Lizbeth Anahí Portillo-Torres10Área Académica de Química, Instituto de Ciencias Básicas e Ingeniería, Universidad Autónoma del Estado de Hidalgo, Hidalgo 42184, MexicoÁrea Académica de Enfermería, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Hidalgo 42060, MexicoÁrea Académica de Química, Instituto de Ciencias Básicas e Ingeniería, Universidad Autónoma del Estado de Hidalgo, Hidalgo 42184, MexicoÁrea Académica de Química, Instituto de Ciencias Básicas e Ingeniería, Universidad Autónoma del Estado de Hidalgo, Hidalgo 42184, MexicoÁrea Académica de Química, Instituto de Ciencias Básicas e Ingeniería, Universidad Autónoma del Estado de Hidalgo, Hidalgo 42184, MexicoÁrea Académica de Química, Instituto de Ciencias Básicas e Ingeniería, Universidad Autónoma del Estado de Hidalgo, Hidalgo 42184, MexicoÁrea Académica de Química, Instituto de Ciencias Básicas e Ingeniería, Universidad Autónoma del Estado de Hidalgo, Hidalgo 42184, MexicoÁrea Académica de Odontología, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Hidalgo 42060, MexicoÁrea Académica de Química, Instituto de Ciencias Básicas e Ingeniería, Universidad Autónoma del Estado de Hidalgo, Hidalgo 42184, MexicoEscuela Superior de Tlahuelilpan, Área Académica de Enfermería, Universidad Autónoma del Estado de Hidalgo, Hidalgo 42780, MexicoIngeniería Agroindustrial, Universidad Politécnica de Francisco I. Madero, Hidalgo 42660, MexicoThis research explored the potential of plant antimicrobial compounds as natural alternatives to synthetic antimicrobials in the food and pharmaceutical industries, emphasizing the urgent need to combat antimicrobial resistance. It detailed various mechanisms by which these plant-derived compounds inhibit microbial growth, including disrupting cell membrane integrity, impeding cell wall and protein synthesis, and preventing biofilm formation, ultimately leading to bacterial cell death. This study highlighted the specific effects of plant antimicrobials on bacterial cells, such as inhibiting biofilm formation, cellular respiration, and cell motility, while also modulating oxygen consumption and reactive oxygen species generation, which are vital in addressing biofilm-mediated infections. Additionally, these compounds can regulate the expression of virulence factors and efflux pumps, enhancing antibiotic efficacy. A bibliometric analysis revealed a growing trend in research output and international collaboration, particularly from China and the United States, with key journals including “Frontiers in Microbiology” and “Antimicrobial Agents and Chemotherapy.” The analysis identified six clusters related to plant antimicrobial research, underscoring the need for further investigation into the mechanisms and applications of these bioactive compounds. In conclusion, understanding the action of plant antimicrobials is important for their effective application in combating antimicrobial resistance.https://www.mdpi.com/2076-3417/15/7/3516plant antimicrobial compoundsantimicrobial resistancenatural alternativesmechanisms of actionbibliometric analysis |
| spellingShingle | Jesús Guadalupe Pérez-Flores Laura García-Curiel Emmanuel Pérez-Escalante Elizabeth Contreras-López Guadalupe Yoselín Aguilar-Lira Carlos Ángel-Jijón Luis Guillermo González-Olivares Elena Saraí Baena-Santillán Israel Oswaldo Ocampo-Salinas José Antonio Guerrero-Solano Lizbeth Anahí Portillo-Torres Plant Antimicrobial Compounds and Their Mechanisms of Action on Spoilage and Pathogenic Bacteria: A Bibliometric Study and Literature Review Applied Sciences plant antimicrobial compounds antimicrobial resistance natural alternatives mechanisms of action bibliometric analysis |
| title | Plant Antimicrobial Compounds and Their Mechanisms of Action on Spoilage and Pathogenic Bacteria: A Bibliometric Study and Literature Review |
| title_full | Plant Antimicrobial Compounds and Their Mechanisms of Action on Spoilage and Pathogenic Bacteria: A Bibliometric Study and Literature Review |
| title_fullStr | Plant Antimicrobial Compounds and Their Mechanisms of Action on Spoilage and Pathogenic Bacteria: A Bibliometric Study and Literature Review |
| title_full_unstemmed | Plant Antimicrobial Compounds and Their Mechanisms of Action on Spoilage and Pathogenic Bacteria: A Bibliometric Study and Literature Review |
| title_short | Plant Antimicrobial Compounds and Their Mechanisms of Action on Spoilage and Pathogenic Bacteria: A Bibliometric Study and Literature Review |
| title_sort | plant antimicrobial compounds and their mechanisms of action on spoilage and pathogenic bacteria a bibliometric study and literature review |
| topic | plant antimicrobial compounds antimicrobial resistance natural alternatives mechanisms of action bibliometric analysis |
| url | https://www.mdpi.com/2076-3417/15/7/3516 |
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