MEK inhibitors for the treatment of immunotherapy-resistant, AGK-BRAF fusion advanced acral melanoma: a case report and literature review

MEK inhibitors for the treatment of immunotherapy-resistant, AGK-BRAF fusion advanced acral melanoma: a case report and literature review

Abstract Purpose Acral melanoma (AM), a rare and aggressive melanoma subtype with poor prognosis, presents unique challenges in treatment due to its distinct molecular and immune characteristics. This case report describes a patient with AM harboring an AGK-BRAF fusion mutation, aiming to explore po...

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Bibliographic Details
Main Authors: Yanling Zhang, Xifeng Zhang, Weikang Shao, Ji Gao, Mei Xiang, Yan Wang, Mengmeng Liu, Weizhen Zhang, Xianbin Liang
Format: Article
Language:English
Published: Springer 2025-04-01
Series:Journal of Cancer Research and Clinical Oncology
Subjects:
Acral melanoma
AGK-BRAF fusion
Immunotherapy
Tumor immune microenvironment
MEK inhibitors
Online Access:https://doi.org/10.1007/s00432-025-06083-3
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