Corneal neovascularization: a modern view of molecular mechanisms and methods of therapy
This review provides a detailed summary of the issues of etiology, pathogenesis and molecular mechanisms of corneal neovascularization. Signaling molecules involved in the process of neovasculogenesis, as well as their antagonists, antiangiogenic factors, are described. The role of signaling protein...
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| Format: | Article |
| Language: | Russian |
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Real Time Ltd
2023-07-01
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| Series: | Российский офтальмологический журнал |
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| Online Access: | https://roj.igb.ru/jour/article/view/1251 |
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| author | G. S. Arzhimatova E. A. Salikhov M. Y. Shemyakin |
| author_facet | G. S. Arzhimatova E. A. Salikhov M. Y. Shemyakin |
| author_sort | G. S. Arzhimatova |
| collection | DOAJ |
| description | This review provides a detailed summary of the issues of etiology, pathogenesis and molecular mechanisms of corneal neovascularization. Signaling molecules involved in the process of neovasculogenesis, as well as their antagonists, antiangiogenic factors, are described. The role of signaling proteins VEGF, MMP and their receptors as modern targets of therapy is described on the basis of a series of clinical studies. The potentials of gene and bioengineering therapy as a promising method of treating corneal neovascularization are presented. |
| format | Article |
| id | doaj-art-fe4d7362c2af47248bcdd3ad8db7b81e |
| institution | DOAJ |
| issn | 2072-0076 2587-5760 |
| language | Russian |
| publishDate | 2023-07-01 |
| publisher | Real Time Ltd |
| record_format | Article |
| series | Российский офтальмологический журнал |
| spelling | doaj-art-fe4d7362c2af47248bcdd3ad8db7b81e2025-08-20T03:19:24ZrusReal Time LtdРоссийский офтальмологический журнал2072-00762587-57602023-07-0116215315910.21516/2072-0076-2023-16-2-153-159596Corneal neovascularization: a modern view of molecular mechanisms and methods of therapyG. S. Arzhimatova0E. A. Salikhov1M. Y. Shemyakin2Russian Medical Academy of Continuing Professional Education; Moscow City Ophthalmological Center, S.P. Botkin HospitalMoscow City Ophthalmological Center, S.P. Botkin HospitalMoscow City Ophthalmological Center, S.P. Botkin HospitalThis review provides a detailed summary of the issues of etiology, pathogenesis and molecular mechanisms of corneal neovascularization. Signaling molecules involved in the process of neovasculogenesis, as well as their antagonists, antiangiogenic factors, are described. The role of signaling proteins VEGF, MMP and their receptors as modern targets of therapy is described on the basis of a series of clinical studies. The potentials of gene and bioengineering therapy as a promising method of treating corneal neovascularization are presented.https://roj.igb.ru/jour/article/view/1251corneal neovascularization therapypro-angiogenic factorsanti-angiogenic factorsanti-vegf therapygene pathways for corneal neovasculogenesis |
| spellingShingle | G. S. Arzhimatova E. A. Salikhov M. Y. Shemyakin Corneal neovascularization: a modern view of molecular mechanisms and methods of therapy Российский офтальмологический журнал corneal neovascularization therapy pro-angiogenic factors anti-angiogenic factors anti-vegf therapy gene pathways for corneal neovasculogenesis |
| title | Corneal neovascularization: a modern view of molecular mechanisms and methods of therapy |
| title_full | Corneal neovascularization: a modern view of molecular mechanisms and methods of therapy |
| title_fullStr | Corneal neovascularization: a modern view of molecular mechanisms and methods of therapy |
| title_full_unstemmed | Corneal neovascularization: a modern view of molecular mechanisms and methods of therapy |
| title_short | Corneal neovascularization: a modern view of molecular mechanisms and methods of therapy |
| title_sort | corneal neovascularization a modern view of molecular mechanisms and methods of therapy |
| topic | corneal neovascularization therapy pro-angiogenic factors anti-angiogenic factors anti-vegf therapy gene pathways for corneal neovasculogenesis |
| url | https://roj.igb.ru/jour/article/view/1251 |
| work_keys_str_mv | AT gsarzhimatova cornealneovascularizationamodernviewofmolecularmechanismsandmethodsoftherapy AT easalikhov cornealneovascularizationamodernviewofmolecularmechanismsandmethodsoftherapy AT myshemyakin cornealneovascularizationamodernviewofmolecularmechanismsandmethodsoftherapy |