Clinical profile and outcome of adult Hodgkin lymphoma: Experience from a tertiary care institution
Treatment and outcome of Hodgkin lymphoma (HL) are the true success story of modern medicine. The data from the developing countries on long-term outcome of patients with HL is sparse. Aims: Primary objective is to assess the progression-free survival (PFS). Secondary objective are overall survival...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Thieme Medical and Scientific Publishers Pvt. Ltd.
2015-01-01
|
| Series: | Indian Journal of Medical and Paediatric Oncology |
| Subjects: | |
| Online Access: | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2015;volume=36;issue=4;spage=255;epage=260;aulast=Maddi |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849739654216024064 |
|---|---|
| author | Rahul Narayan Maddi Vijay Gandhi Linga Kalpathi Krishnamani Iyer Joseph Stalin Chowdary Sadashivudu Gundeti Raghunadharao Digumarti Tara Roshini Paul |
| author_facet | Rahul Narayan Maddi Vijay Gandhi Linga Kalpathi Krishnamani Iyer Joseph Stalin Chowdary Sadashivudu Gundeti Raghunadharao Digumarti Tara Roshini Paul |
| author_sort | Rahul Narayan Maddi |
| collection | DOAJ |
| description | Treatment and outcome of Hodgkin lymphoma (HL) are the true success story of modern medicine. The data from the developing countries on long-term outcome of patients with HL is sparse. Aims: Primary objective is to assess the progression-free survival (PFS). Secondary objective are overall survival (OS) and toxicities. Settings and Design: This is a retrospective analysis from the case records from a single institution. Materials and Methods: Institutional Ethical Committee approval was obtained. Between January 1991 and December 2010, 301 patients (age ≥18 years) underwent treatment at our institution. Statistical Analysis: Kaplan-Meyer curves were used to calculate the PFS and OS. Results: The median age at presentation was 36 years, range from 19 to 75 years. The male to female ratio was 2.9:1. Seventy-five percent of patients had B symptoms. Majority presented in advanced stage (Stage III and IV) disease (64.7%). Mixed cellularity (74.4%) was the most common histology, followed by nodular sclerosis (13.9%). The most common chemotherapy regimen used was ABVD (61%). Conclusions: Median follow-up of the cohort was 18.5 months (range 2-225). PFS and OS rate at 5 years is 66.3% and 79.7% respectively. |
| format | Article |
| id | doaj-art-fe4bcf399abb470dbd6293f49dc6ae21 |
| institution | DOAJ |
| issn | 0971-5851 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Medical and Paediatric Oncology |
| spelling | doaj-art-fe4bcf399abb470dbd6293f49dc6ae212025-08-20T03:06:13ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Medical and Paediatric Oncology0971-58512015-01-0136425526010.4103/0971-5851.171550Clinical profile and outcome of adult Hodgkin lymphoma: Experience from a tertiary care institutionRahul Narayan MaddiVijay Gandhi LingaKalpathi Krishnamani IyerJoseph Stalin ChowdarySadashivudu GundetiRaghunadharao DigumartiTara Roshini PaulTreatment and outcome of Hodgkin lymphoma (HL) are the true success story of modern medicine. The data from the developing countries on long-term outcome of patients with HL is sparse. Aims: Primary objective is to assess the progression-free survival (PFS). Secondary objective are overall survival (OS) and toxicities. Settings and Design: This is a retrospective analysis from the case records from a single institution. Materials and Methods: Institutional Ethical Committee approval was obtained. Between January 1991 and December 2010, 301 patients (age ≥18 years) underwent treatment at our institution. Statistical Analysis: Kaplan-Meyer curves were used to calculate the PFS and OS. Results: The median age at presentation was 36 years, range from 19 to 75 years. The male to female ratio was 2.9:1. Seventy-five percent of patients had B symptoms. Majority presented in advanced stage (Stage III and IV) disease (64.7%). Mixed cellularity (74.4%) was the most common histology, followed by nodular sclerosis (13.9%). The most common chemotherapy regimen used was ABVD (61%). Conclusions: Median follow-up of the cohort was 18.5 months (range 2-225). PFS and OS rate at 5 years is 66.3% and 79.7% respectively.http://www.ijmpo.org/article.asp?issn=0971-5851;year=2015;volume=36;issue=4;spage=255;epage=260;aulast=MaddiChemotherapy and toxicitiesHodgkin lymphomasurvival |
| spellingShingle | Rahul Narayan Maddi Vijay Gandhi Linga Kalpathi Krishnamani Iyer Joseph Stalin Chowdary Sadashivudu Gundeti Raghunadharao Digumarti Tara Roshini Paul Clinical profile and outcome of adult Hodgkin lymphoma: Experience from a tertiary care institution Indian Journal of Medical and Paediatric Oncology Chemotherapy and toxicities Hodgkin lymphoma survival |
| title | Clinical profile and outcome of adult Hodgkin lymphoma: Experience from a tertiary care institution |
| title_full | Clinical profile and outcome of adult Hodgkin lymphoma: Experience from a tertiary care institution |
| title_fullStr | Clinical profile and outcome of adult Hodgkin lymphoma: Experience from a tertiary care institution |
| title_full_unstemmed | Clinical profile and outcome of adult Hodgkin lymphoma: Experience from a tertiary care institution |
| title_short | Clinical profile and outcome of adult Hodgkin lymphoma: Experience from a tertiary care institution |
| title_sort | clinical profile and outcome of adult hodgkin lymphoma experience from a tertiary care institution |
| topic | Chemotherapy and toxicities Hodgkin lymphoma survival |
| url | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2015;volume=36;issue=4;spage=255;epage=260;aulast=Maddi |
| work_keys_str_mv | AT rahulnarayanmaddi clinicalprofileandoutcomeofadulthodgkinlymphomaexperiencefromatertiarycareinstitution AT vijaygandhilinga clinicalprofileandoutcomeofadulthodgkinlymphomaexperiencefromatertiarycareinstitution AT kalpathikrishnamaniiyer clinicalprofileandoutcomeofadulthodgkinlymphomaexperiencefromatertiarycareinstitution AT josephstalinchowdary clinicalprofileandoutcomeofadulthodgkinlymphomaexperiencefromatertiarycareinstitution AT sadashivudugundeti clinicalprofileandoutcomeofadulthodgkinlymphomaexperiencefromatertiarycareinstitution AT raghunadharaodigumarti clinicalprofileandoutcomeofadulthodgkinlymphomaexperiencefromatertiarycareinstitution AT tararoshinipaul clinicalprofileandoutcomeofadulthodgkinlymphomaexperiencefromatertiarycareinstitution |