Identifying the role of Phytomolecules in the management of liver diseases by modulating NRF2 pathway: A Scoping Review Protocol [version 2; peer review: 2 approved]
Background The Liver is a vital organ in the human body, which plays a crucial role in various physiological processes. Oxidative stress is a critical factor in the pathogenesis and progression of various liver diseases, contributing to cellular damage and dysfunction. The Liver is particularly vuln...
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F1000 Research Ltd
2024-07-01
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| author | Richard Lobo Krishnadas Nandakumar Priyobrat Rajkhowa Ajay Mili |
| author_facet | Richard Lobo Krishnadas Nandakumar Priyobrat Rajkhowa Ajay Mili |
| author_sort | Richard Lobo |
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| description | Background The Liver is a vital organ in the human body, which plays a crucial role in various physiological processes. Oxidative stress is a critical factor in the pathogenesis and progression of various liver diseases, contributing to cellular damage and dysfunction. The Liver is particularly vulnerable to the harmful effects of reactive oxygen species when the balance between their production and the body’s antioxidant defense mechanisms is disrupted. The nuclear factor erythroid 2-related factor 2 (NRF2) pathway has emerged as a promising therapeutic target for liver diseases due to its pivotal role in cellular defense against oxidative stress and inflammation. Plants have always been a source of drugs which has been used to treat various pharmacological disorders and most of its activity is due to its potential as an antioxidant. However, the specific mechanisms by which they interact with the NRF2 pathway and confer protection against liver diseases remain inadequately elucidated. Therefore, this scoping review aims to identify and analyze the existing literature pertaining to the relationship between Phytomolecules, which can modulate NRF2 and protect against liver diseases. Methods The proposed scoping review will follow the steps given by “Arksey and O’Malley and Levac et al”. Electronic databases (PubMed/MEDLINE, Embase, etc.) will be searched for recent relevant studies. A predefined criterion for the inclusion and exclusion of studies will be independently adopted by two reviewers. The review will be presented as per the “Preferred Reporting Items for Systematic Reviews and Meta-analyses Extension for Scoping Review (PRISMA-ScR)” guidelines. Conclusion The scoping review finding is expected to help understanding the role of Phytomolecules in preventing liver diseases by modulating the NRF2 pathway. Ultimately, this review will serve as a foundational step toward developing targeted interventions to improve liver health outcomes and reduce the global burden of liver diseases. |
| format | Article |
| id | doaj-art-fe46d331e0df4595b59ec3789030960f |
| institution | DOAJ |
| issn | 2046-1402 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | F1000 Research Ltd |
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| spelling | doaj-art-fe46d331e0df4595b59ec3789030960f2025-08-20T03:14:45ZengF1000 Research LtdF1000Research2046-14022024-07-011310.12688/f1000research.150635.2168761Identifying the role of Phytomolecules in the management of liver diseases by modulating NRF2 pathway: A Scoping Review Protocol [version 2; peer review: 2 approved]Richard Lobo0https://orcid.org/0000-0003-3202-1108Krishnadas Nandakumar1https://orcid.org/0000-0001-6653-4660Priyobrat Rajkhowa2Ajay Mili3https://orcid.org/0000-0002-0718-6114Pharmacognosy, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, IndiaPharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, IndiaHealth Policy, Prasanna School of Public Health, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, IndiaPharmacognosy, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, IndiaBackground The Liver is a vital organ in the human body, which plays a crucial role in various physiological processes. Oxidative stress is a critical factor in the pathogenesis and progression of various liver diseases, contributing to cellular damage and dysfunction. The Liver is particularly vulnerable to the harmful effects of reactive oxygen species when the balance between their production and the body’s antioxidant defense mechanisms is disrupted. The nuclear factor erythroid 2-related factor 2 (NRF2) pathway has emerged as a promising therapeutic target for liver diseases due to its pivotal role in cellular defense against oxidative stress and inflammation. Plants have always been a source of drugs which has been used to treat various pharmacological disorders and most of its activity is due to its potential as an antioxidant. However, the specific mechanisms by which they interact with the NRF2 pathway and confer protection against liver diseases remain inadequately elucidated. Therefore, this scoping review aims to identify and analyze the existing literature pertaining to the relationship between Phytomolecules, which can modulate NRF2 and protect against liver diseases. Methods The proposed scoping review will follow the steps given by “Arksey and O’Malley and Levac et al”. Electronic databases (PubMed/MEDLINE, Embase, etc.) will be searched for recent relevant studies. A predefined criterion for the inclusion and exclusion of studies will be independently adopted by two reviewers. The review will be presented as per the “Preferred Reporting Items for Systematic Reviews and Meta-analyses Extension for Scoping Review (PRISMA-ScR)” guidelines. Conclusion The scoping review finding is expected to help understanding the role of Phytomolecules in preventing liver diseases by modulating the NRF2 pathway. Ultimately, this review will serve as a foundational step toward developing targeted interventions to improve liver health outcomes and reduce the global burden of liver diseases.https://f1000research.com/articles/13-522/v2NRF2 pathway Liver diseases Phytomolecules Oxidative stresseng |
| spellingShingle | Richard Lobo Krishnadas Nandakumar Priyobrat Rajkhowa Ajay Mili Identifying the role of Phytomolecules in the management of liver diseases by modulating NRF2 pathway: A Scoping Review Protocol [version 2; peer review: 2 approved] F1000Research NRF2 pathway Liver diseases Phytomolecules Oxidative stress eng |
| title | Identifying the role of Phytomolecules in the management of liver diseases by modulating NRF2 pathway: A Scoping Review Protocol [version 2; peer review: 2 approved] |
| title_full | Identifying the role of Phytomolecules in the management of liver diseases by modulating NRF2 pathway: A Scoping Review Protocol [version 2; peer review: 2 approved] |
| title_fullStr | Identifying the role of Phytomolecules in the management of liver diseases by modulating NRF2 pathway: A Scoping Review Protocol [version 2; peer review: 2 approved] |
| title_full_unstemmed | Identifying the role of Phytomolecules in the management of liver diseases by modulating NRF2 pathway: A Scoping Review Protocol [version 2; peer review: 2 approved] |
| title_short | Identifying the role of Phytomolecules in the management of liver diseases by modulating NRF2 pathway: A Scoping Review Protocol [version 2; peer review: 2 approved] |
| title_sort | identifying the role of phytomolecules in the management of liver diseases by modulating nrf2 pathway a scoping review protocol version 2 peer review 2 approved |
| topic | NRF2 pathway Liver diseases Phytomolecules Oxidative stress eng |
| url | https://f1000research.com/articles/13-522/v2 |
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