Sodium-glucose cotransporter type 2 inhibitors: successful running after two hares
The review is devoted to the clinical efficacy of sodium-glucose cotransporter type 2 (SGLT2) inhibitors. Information on the mechanisms of drug action is given, as well as rationale for their use in the management of patients with diabetes and heart failure (HF) is provided. The results of large-sca...
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| Format: | Article |
| Language: | Russian |
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«FIRMA «SILICEA» LLC
2021-07-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/4534 |
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| author | N. B. Perepech I. E. Mikhailova |
| author_facet | N. B. Perepech I. E. Mikhailova |
| author_sort | N. B. Perepech |
| collection | DOAJ |
| description | The review is devoted to the clinical efficacy of sodium-glucose cotransporter type 2 (SGLT2) inhibitors. Information on the mechanisms of drug action is given, as well as rationale for their use in the management of patients with diabetes and heart failure (HF) is provided. The results of large-scale randomized clinical trials evaluating the efficacy of SGLT2 inhibitors are discussed. We showed the beneficial effect of SGLT-2 inhibitors on the risk of cardiovascular events in patients with type 2 diabetes. In addition, an evidence of the ability of dapagliflozin and empagliflozin to improve the prognosis of patients with HF with reduced ejection fraction without diabetes are presented. The evidence and mechanisms of the nephroprotective action of SGLT2 inhibitors in patients with diabetes and HF are considered. |
| format | Article |
| id | doaj-art-fe3f026a31e64973b029521f97d0b813 |
| institution | DOAJ |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2021-07-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj-art-fe3f026a31e64973b029521f97d0b8132025-08-20T03:21:31Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202021-07-01262S10.15829/1560-4071-2021-45343292Sodium-glucose cotransporter type 2 inhibitors: successful running after two haresN. B. Perepech0I. E. Mikhailova1Saint Petersburg State UniversitySaint Petersburg State UniversityThe review is devoted to the clinical efficacy of sodium-glucose cotransporter type 2 (SGLT2) inhibitors. Information on the mechanisms of drug action is given, as well as rationale for their use in the management of patients with diabetes and heart failure (HF) is provided. The results of large-scale randomized clinical trials evaluating the efficacy of SGLT2 inhibitors are discussed. We showed the beneficial effect of SGLT-2 inhibitors on the risk of cardiovascular events in patients with type 2 diabetes. In addition, an evidence of the ability of dapagliflozin and empagliflozin to improve the prognosis of patients with HF with reduced ejection fraction without diabetes are presented. The evidence and mechanisms of the nephroprotective action of SGLT2 inhibitors in patients with diabetes and HF are considered.https://russjcardiol.elpub.ru/jour/article/view/4534keywords: sodium-glucose cotransporter type 2 inhibitorsdiabetesheart failureprognosis |
| spellingShingle | N. B. Perepech I. E. Mikhailova Sodium-glucose cotransporter type 2 inhibitors: successful running after two hares Российский кардиологический журнал keywords: sodium-glucose cotransporter type 2 inhibitors diabetes heart failure prognosis |
| title | Sodium-glucose cotransporter type 2 inhibitors: successful running after two hares |
| title_full | Sodium-glucose cotransporter type 2 inhibitors: successful running after two hares |
| title_fullStr | Sodium-glucose cotransporter type 2 inhibitors: successful running after two hares |
| title_full_unstemmed | Sodium-glucose cotransporter type 2 inhibitors: successful running after two hares |
| title_short | Sodium-glucose cotransporter type 2 inhibitors: successful running after two hares |
| title_sort | sodium glucose cotransporter type 2 inhibitors successful running after two hares |
| topic | keywords: sodium-glucose cotransporter type 2 inhibitors diabetes heart failure prognosis |
| url | https://russjcardiol.elpub.ru/jour/article/view/4534 |
| work_keys_str_mv | AT nbperepech sodiumglucosecotransportertype2inhibitorssuccessfulrunningaftertwohares AT iemikhailova sodiumglucosecotransportertype2inhibitorssuccessfulrunningaftertwohares |