SERPINA1 methylation as a novel diagnostic marker for early-stage papillary thyroid carcinoma via MAPK6-AKT/mTOR pathway

SERPINA1 methylation as a novel diagnostic marker for early-stage papillary thyroid carcinoma via MAPK6-AKT/mTOR pathway

Abstract Most thyroid nodules can be diagnosed preoperatively by ultrasonography and fine-needle aspiration biopsy. However, accurately differentiating between benign nodules or indolent thyroid tumors and aggressive thyroid cancers remains a significant clinical challenge when the biopsy results ar...

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Bibliographic Details
Main Authors: Junjie Li, Haixia Huang, Yifei Yin, Yizhu Mao, Mengxia Li, Hong Li, Chenxia Jiang, Rongxi Yang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Clinical Epigenetics
Subjects:
SERPINA1
Benign thyroid nodule
Papillary thyroid carcinoma
Thyroid cancer
Diagnosis
DNA methylation
Online Access:https://doi.org/10.1186/s13148-025-01891-3
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