Spontaneous regression of breast cancer with immune response: a case report
Abstract Background Spontaneous regression (SR) is a rare phenomenon in which a cancer disappears or remits without treatment. We report a case of breast cancer that showed spontaneous tumor regression in the surgical specimen after core needle biopsy. Case presentation A 59-year-old woman came to o...
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Japan Surgical Society
2021-01-01
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| Series: | Surgical Case Reports |
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| Online Access: | https://doi.org/10.1186/s40792-020-01103-5 |
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| author | Masahiro Ohara Yumiko Koi Tatsunari Sasada Keiko Kajitani Seishi Mizuno Ai Takata Atsuko Okamoto Ikuko Nagata Mie Sumita Kaita Imachi Mayumi Watanabe Yutaka Daimaru Shingo Kawamura |
| author_facet | Masahiro Ohara Yumiko Koi Tatsunari Sasada Keiko Kajitani Seishi Mizuno Ai Takata Atsuko Okamoto Ikuko Nagata Mie Sumita Kaita Imachi Mayumi Watanabe Yutaka Daimaru Shingo Kawamura |
| author_sort | Masahiro Ohara |
| collection | DOAJ |
| description | Abstract Background Spontaneous regression (SR) is a rare phenomenon in which a cancer disappears or remits without treatment. We report a case of breast cancer that showed spontaneous tumor regression in the surgical specimen after core needle biopsy. Case presentation A 59-year-old woman came to our hospital complaining of a painful lump in the right breast. In the upper-outer quadrant of the right breast, a tumor with an unclear boundary, 30 mm in diameter, was palpable. In pathological findings from needle biopsy, the tumor was diagnosed as solid-type invasive ductal breast carcinoma. Partial coagulation necrosis was generated in estrogen receptor-negative, HER2-negative, and AE1/AE3-positive ductal carcinoma without infiltration of lymphocytes. Surgery for right breast cancer was then performed. Histological examination of the surgical specimen revealed the tumor was invasive ductal carcinoma with lymphocyte infiltration, coagulation necrosis, and fibrous tissue with hemosiderin. The tumor formed a solid nest, 3 mm in diameter, suggesting the possibility of SR. Conclusions Immune responses, infection, hormones, surgical stress, and ischemia have been reported as mechanisms of SR. The findings in this case strongly suggest that SR of breast cancer is associated with anti-tumor immune responses. |
| format | Article |
| id | doaj-art-fe3a4f58a5e148649dacf4a3ea33efb0 |
| institution | DOAJ |
| issn | 2198-7793 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Japan Surgical Society |
| record_format | Article |
| series | Surgical Case Reports |
| spelling | doaj-art-fe3a4f58a5e148649dacf4a3ea33efb02025-08-20T02:49:20ZengJapan Surgical SocietySurgical Case Reports2198-77932021-01-01711610.1186/s40792-020-01103-5Spontaneous regression of breast cancer with immune response: a case reportMasahiro Ohara0Yumiko Koi1Tatsunari Sasada2Keiko Kajitani3Seishi Mizuno4Ai Takata5Atsuko Okamoto6Ikuko Nagata7Mie Sumita8Kaita Imachi9Mayumi Watanabe10Yutaka Daimaru11Shingo Kawamura12Department of Breast Surgery, Hiroshima General HospitalDepartment of Breast Surgery, Hiroshima General HospitalDepartment of Breast Surgery, Hiroshima General HospitalDepartment of Breast Surgery, Hiroshima General HospitalSection of Pathological Research and Laboratory, Hiroshima General HospitalSection of Pathological Research and Laboratory, Hiroshima General HospitalSection of Pathological Research and Laboratory, Hiroshima General HospitalSection of Pathological Research and Laboratory, Hiroshima General HospitalSection of Pathological Research and Laboratory, Hiroshima General HospitalSection of Pathological Research and Laboratory, Hiroshima General HospitalSection of Pathological Research and Laboratory, Hiroshima General HospitalSection of Pathological Research and Laboratory, Hiroshima General HospitalSuzumine Imanaka ClinicAbstract Background Spontaneous regression (SR) is a rare phenomenon in which a cancer disappears or remits without treatment. We report a case of breast cancer that showed spontaneous tumor regression in the surgical specimen after core needle biopsy. Case presentation A 59-year-old woman came to our hospital complaining of a painful lump in the right breast. In the upper-outer quadrant of the right breast, a tumor with an unclear boundary, 30 mm in diameter, was palpable. In pathological findings from needle biopsy, the tumor was diagnosed as solid-type invasive ductal breast carcinoma. Partial coagulation necrosis was generated in estrogen receptor-negative, HER2-negative, and AE1/AE3-positive ductal carcinoma without infiltration of lymphocytes. Surgery for right breast cancer was then performed. Histological examination of the surgical specimen revealed the tumor was invasive ductal carcinoma with lymphocyte infiltration, coagulation necrosis, and fibrous tissue with hemosiderin. The tumor formed a solid nest, 3 mm in diameter, suggesting the possibility of SR. Conclusions Immune responses, infection, hormones, surgical stress, and ischemia have been reported as mechanisms of SR. The findings in this case strongly suggest that SR of breast cancer is associated with anti-tumor immune responses.https://doi.org/10.1186/s40792-020-01103-5Breast cancerSpontaneous regressionImmunogenic cell death |
| spellingShingle | Masahiro Ohara Yumiko Koi Tatsunari Sasada Keiko Kajitani Seishi Mizuno Ai Takata Atsuko Okamoto Ikuko Nagata Mie Sumita Kaita Imachi Mayumi Watanabe Yutaka Daimaru Shingo Kawamura Spontaneous regression of breast cancer with immune response: a case report Surgical Case Reports Breast cancer Spontaneous regression Immunogenic cell death |
| title | Spontaneous regression of breast cancer with immune response: a case report |
| title_full | Spontaneous regression of breast cancer with immune response: a case report |
| title_fullStr | Spontaneous regression of breast cancer with immune response: a case report |
| title_full_unstemmed | Spontaneous regression of breast cancer with immune response: a case report |
| title_short | Spontaneous regression of breast cancer with immune response: a case report |
| title_sort | spontaneous regression of breast cancer with immune response a case report |
| topic | Breast cancer Spontaneous regression Immunogenic cell death |
| url | https://doi.org/10.1186/s40792-020-01103-5 |
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