Multi-target neuroprotection by dl-PHPB in APP/PS1 mice: a proteomic analysis

Multi-target neuroprotection by dl-PHPB in APP/PS1 mice: a proteomic analysis

IntroductionDl-PHPB [potassium 2-(1-hydroxypentyl) benzoate] demonstrates robust neuroprotective effects in preclinical models of Alzheimer’s disease (AD), significantly ameliorating cognitive deficits and pathological hallmarks. However, the underlying mechanism remains largely unclear. The current...

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Bibliographic Details
Main Authors: Yingni Sun, Guoliang Bai, Kangmin Yang, Yong Feng, Hongmei Sun, Li Xian, Hongwei Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
Alzheimer’s disease
LC-MS/MS
proteomics
dl-PHPB
biomarker
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1554168/full
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