Serum 25-Hydroxyvitamin D3 and BAFF Levels Are Associated with Disease Activity in Primary Sjogren’s Syndrome
The study investigated the association between disease activity and serum 25-hydroxyvitamin D3 (25(OH)-D3), B cell activation of the tumor necrosis factor family (BAFF), or β2 microglobulin in patients with primary Sjogren’s syndrome (SS). Sixty-nine primary SS patients and 22 sicca control patients...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2016/5781070 |
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| author | Sang Jin Lee Hye Jin Oh Byoong Yong Choi Yu Jin Jang Joo Youn Lee Jin Kyun Park Yeong Wook Song |
| author_facet | Sang Jin Lee Hye Jin Oh Byoong Yong Choi Yu Jin Jang Joo Youn Lee Jin Kyun Park Yeong Wook Song |
| author_sort | Sang Jin Lee |
| collection | DOAJ |
| description | The study investigated the association between disease activity and serum 25-hydroxyvitamin D3 (25(OH)-D3), B cell activation of the tumor necrosis factor family (BAFF), or β2 microglobulin in patients with primary Sjogren’s syndrome (SS). Sixty-nine primary SS patients and 22 sicca control patients were included in the study. Disease activity was measured with EULAR Sjogren’s syndrome disease activity index (ESSDAI). Serum levels of 25(OH)-D3 and β2 microglobulin were measured by radioimmunoassay and BAFF was measured by an enzyme-linked immunosorbent assay. Serum levels of 25(OH)-D3 were significantly lower in SS patients compared to the sicca controls (p=0.036). Serum levels of BAFF tended to be higher (p=0.225) and those of β2 microglobulin were significantly higher in patients with SS than in sicca controls (p=0.023). In univariate regression analyses, ESSDAI was significantly associated with serum levels of 25(OH)-D3, BAFF, and β2 microglobulin. After stepwise backward multivariate linear regression analyses including age and acute phase reactants, ESSDAI was associated with 25(OH)-D3 (β = −0.042, p=0.015) and BAFF (β = 0.001, p=0.015) in SS patients. In SS patients, ESSDAI is negatively associated with serum levels of 25(OH)-D3 and positively associated with BAFF. |
| format | Article |
| id | doaj-art-fe291f2cab384562aefaa174319f435b |
| institution | OA Journals |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-fe291f2cab384562aefaa174319f435b2025-08-20T02:22:32ZengWileyJournal of Immunology Research2314-88612314-71562016-01-01201610.1155/2016/57810705781070Serum 25-Hydroxyvitamin D3 and BAFF Levels Are Associated with Disease Activity in Primary Sjogren’s SyndromeSang Jin Lee0Hye Jin Oh1Byoong Yong Choi2Yu Jin Jang3Joo Youn Lee4Jin Kyun Park5Yeong Wook Song6Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of KoreaDivision of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of KoreaDivision of Rheumatology, Department of Internal Medicine, Seoul Medical Center, Seoul, Republic of KoreaDepartment of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine, Medical Research Center, Seoul National University, Seoul, Republic of KoreaDepartment of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine, Medical Research Center, Seoul National University, Seoul, Republic of KoreaDivision of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of KoreaDivision of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of KoreaThe study investigated the association between disease activity and serum 25-hydroxyvitamin D3 (25(OH)-D3), B cell activation of the tumor necrosis factor family (BAFF), or β2 microglobulin in patients with primary Sjogren’s syndrome (SS). Sixty-nine primary SS patients and 22 sicca control patients were included in the study. Disease activity was measured with EULAR Sjogren’s syndrome disease activity index (ESSDAI). Serum levels of 25(OH)-D3 and β2 microglobulin were measured by radioimmunoassay and BAFF was measured by an enzyme-linked immunosorbent assay. Serum levels of 25(OH)-D3 were significantly lower in SS patients compared to the sicca controls (p=0.036). Serum levels of BAFF tended to be higher (p=0.225) and those of β2 microglobulin were significantly higher in patients with SS than in sicca controls (p=0.023). In univariate regression analyses, ESSDAI was significantly associated with serum levels of 25(OH)-D3, BAFF, and β2 microglobulin. After stepwise backward multivariate linear regression analyses including age and acute phase reactants, ESSDAI was associated with 25(OH)-D3 (β = −0.042, p=0.015) and BAFF (β = 0.001, p=0.015) in SS patients. In SS patients, ESSDAI is negatively associated with serum levels of 25(OH)-D3 and positively associated with BAFF.http://dx.doi.org/10.1155/2016/5781070 |
| spellingShingle | Sang Jin Lee Hye Jin Oh Byoong Yong Choi Yu Jin Jang Joo Youn Lee Jin Kyun Park Yeong Wook Song Serum 25-Hydroxyvitamin D3 and BAFF Levels Are Associated with Disease Activity in Primary Sjogren’s Syndrome Journal of Immunology Research |
| title | Serum 25-Hydroxyvitamin D3 and BAFF Levels Are Associated with Disease Activity in Primary Sjogren’s Syndrome |
| title_full | Serum 25-Hydroxyvitamin D3 and BAFF Levels Are Associated with Disease Activity in Primary Sjogren’s Syndrome |
| title_fullStr | Serum 25-Hydroxyvitamin D3 and BAFF Levels Are Associated with Disease Activity in Primary Sjogren’s Syndrome |
| title_full_unstemmed | Serum 25-Hydroxyvitamin D3 and BAFF Levels Are Associated with Disease Activity in Primary Sjogren’s Syndrome |
| title_short | Serum 25-Hydroxyvitamin D3 and BAFF Levels Are Associated with Disease Activity in Primary Sjogren’s Syndrome |
| title_sort | serum 25 hydroxyvitamin d3 and baff levels are associated with disease activity in primary sjogren s syndrome |
| url | http://dx.doi.org/10.1155/2016/5781070 |
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