Targeting BATF2-RGS2 axis reduces T-cell exhaustion and restores anti-tumor immunity

Targeting BATF2-RGS2 axis reduces T-cell exhaustion and restores anti-tumor immunity

Abstract Objective This study aims to investigate the role of RGS2 in immune regulation in lung cancer (LC) and explore the regulatory relationship between RGS2 and BATF2 in modulating T cell exhaustion and tumor immune evasion. Methods Single-cell transcriptome-based analysis was performed to ident...

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Bibliographic Details
Main Authors: Xuyu Gu, Chanchan Gao, Xiangyu Su, Yaoyao Zhu, Qiyu Fang, Jia Yu, Ziming Wang, Deping Zhao, Wentian Zhang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Molecular Cancer
Subjects:
RGS2
BATF
T-cell exhaustion
CXCL13
Immunosuppression
Lung cancer
Online Access:https://doi.org/10.1186/s12943-025-02351-5
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