Ultra-processed food intake, genetic polymorphisms and the risk of dyslipidaemia in the adult Korean population
Abstract Objective: This study aimed to examine the association between ultra-processed food intake and dyslipidaemia risk and whether this association varied by the polygenic score for dyslipidaemia in the adult Korean population. Design: Prospective cohort study. Setting: Ultra-processed foo...
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Cambridge University Press
2025-01-01
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| Series: | Public Health Nutrition |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S1368980024002337/type/journal_article |
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| author | Minsu Cho Heejin Lee Jung Eun Lee |
| author_facet | Minsu Cho Heejin Lee Jung Eun Lee |
| author_sort | Minsu Cho |
| collection | DOAJ |
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Abstract
Objective:
This study aimed to examine the association between ultra-processed food intake and dyslipidaemia risk and whether this association varied by the polygenic score for dyslipidaemia in the adult Korean population.
Design:
Prospective cohort study.
Setting:
Ultra-processed foods were identified under the NOVA classification. Participants were categorised into < 5, 5 to < 10, 10 to < 15, 15 to < 20 and ≥ 20 %E/d of ultra-processed food intake. The polygenic scores for dyslipidaemia were calculated from 53 950 SNPs. ORs and 95 % CIs were estimated using multivariate logistic regression models.
Participants:
20 044 Korean adults aged ≥ 40 years in the Health Examinees (HEXA) study, the Cardiovascular Disease Association Study (CAVAS) and the Korea Association Resource (KARE) study.
Results:
During median follow-ups of 4·09, 8·67 and 15·67 years in the HEXA, CAVAS and KARE studies, respectively, there were a total of 7331, 786 and 1732 incident dyslipidaemia events. Ultra-processed food intake was not significantly associated with dyslipidaemia risk. Compared with < 5 %E/d, the pooled OR (95 % CI) of ≥ 20 %E/d of ultra-processed food intake for dyslipidaemia incidence was 1·01 (0·90, 1·13; P for trend = 0·83). There was no interaction by dyslipidaemia-related genetic variations; ORs (95 % CIs) were 1·04 (0·89, 1·22; P for trend = 0·91) and 0·98 (0·84, 1·15; P for trend = 0·72) for individuals with high- and low-polygenic scores, respectively (P for interaction = 0·90).
Conclusions:
No significant association was observed between ultra-processed food intake and the overall risk of dyslipidaemia, nor in subgroups of polygenic scores for dyslipidaemia among Korean adults with low ultra-processed food intake.
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| format | Article |
| id | doaj-art-fe2719343d5446558d0a8ded0ef91bfb |
| institution | OA Journals |
| issn | 1368-9800 1475-2727 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Public Health Nutrition |
| spelling | doaj-art-fe2719343d5446558d0a8ded0ef91bfb2025-08-20T02:07:19ZengCambridge University PressPublic Health Nutrition1368-98001475-27272025-01-012810.1017/S1368980024002337Ultra-processed food intake, genetic polymorphisms and the risk of dyslipidaemia in the adult Korean populationMinsu Cho0Heejin Lee1Jung Eun Lee2https://orcid.org/0000-0003-1141-878XDepartment of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul 08826, KoreaDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USADepartment of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul 08826, Korea The Research Institute of Human Ecology, Seoul National University, Seoul 08826, Korea Abstract Objective: This study aimed to examine the association between ultra-processed food intake and dyslipidaemia risk and whether this association varied by the polygenic score for dyslipidaemia in the adult Korean population. Design: Prospective cohort study. Setting: Ultra-processed foods were identified under the NOVA classification. Participants were categorised into < 5, 5 to < 10, 10 to < 15, 15 to < 20 and ≥ 20 %E/d of ultra-processed food intake. The polygenic scores for dyslipidaemia were calculated from 53 950 SNPs. ORs and 95 % CIs were estimated using multivariate logistic regression models. Participants: 20 044 Korean adults aged ≥ 40 years in the Health Examinees (HEXA) study, the Cardiovascular Disease Association Study (CAVAS) and the Korea Association Resource (KARE) study. Results: During median follow-ups of 4·09, 8·67 and 15·67 years in the HEXA, CAVAS and KARE studies, respectively, there were a total of 7331, 786 and 1732 incident dyslipidaemia events. Ultra-processed food intake was not significantly associated with dyslipidaemia risk. Compared with < 5 %E/d, the pooled OR (95 % CI) of ≥ 20 %E/d of ultra-processed food intake for dyslipidaemia incidence was 1·01 (0·90, 1·13; P for trend = 0·83). There was no interaction by dyslipidaemia-related genetic variations; ORs (95 % CIs) were 1·04 (0·89, 1·22; P for trend = 0·91) and 0·98 (0·84, 1·15; P for trend = 0·72) for individuals with high- and low-polygenic scores, respectively (P for interaction = 0·90). Conclusions: No significant association was observed between ultra-processed food intake and the overall risk of dyslipidaemia, nor in subgroups of polygenic scores for dyslipidaemia among Korean adults with low ultra-processed food intake. https://www.cambridge.org/core/product/identifier/S1368980024002337/type/journal_articleUltra-processed foodDyslipidaemiaPolygenic scoreSNP |
| spellingShingle | Minsu Cho Heejin Lee Jung Eun Lee Ultra-processed food intake, genetic polymorphisms and the risk of dyslipidaemia in the adult Korean population Public Health Nutrition Ultra-processed food Dyslipidaemia Polygenic score SNP |
| title | Ultra-processed food intake, genetic polymorphisms and the risk of dyslipidaemia in the adult Korean population |
| title_full | Ultra-processed food intake, genetic polymorphisms and the risk of dyslipidaemia in the adult Korean population |
| title_fullStr | Ultra-processed food intake, genetic polymorphisms and the risk of dyslipidaemia in the adult Korean population |
| title_full_unstemmed | Ultra-processed food intake, genetic polymorphisms and the risk of dyslipidaemia in the adult Korean population |
| title_short | Ultra-processed food intake, genetic polymorphisms and the risk of dyslipidaemia in the adult Korean population |
| title_sort | ultra processed food intake genetic polymorphisms and the risk of dyslipidaemia in the adult korean population |
| topic | Ultra-processed food Dyslipidaemia Polygenic score SNP |
| url | https://www.cambridge.org/core/product/identifier/S1368980024002337/type/journal_article |
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