Programming megakaryocytes to produce engineered platelets for delivering non-native proteins

Abstract Platelets are anucleate cells naturally filled with secretory granules that store large amounts of protein to be released in response to certain physiological conditions. Cell engineering can endow platelets with the ability to deliver non-native proteins by modifying them as they develop d...

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Bibliographic Details
Main Authors: Farhana Islam, Shwan B. Javdan, Mitchell R. Lewis, James D. Craig, Han Wu, Tara L. Deans
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08017-8
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