A multi-ancestry genome-wide association study identifies novel candidate loci in the RARB gene associated with hypertensive disorders of pregnancy

A multi-ancestry genome-wide association study identifies novel candidate loci in the RARB gene associated with hypertensive disorders of pregnancy

Summary: Genetic factors related to pregnancy-related traits are understudied, especially in ancestrally diverse cohorts. To assess maternal contributions to hypertensive disorders of pregnancy (HDP), we performed a multi-ancestry genome-wide association study (GWAS) of HDP in data from the North Ca...

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Bibliographic Details
Main Authors: Jasmine A. Mack, Adam Burkholder, Farida S. Akhtari, John S. House, Ulla Sovio, Gordon C.S. Smith, Charles P. Schmitt, David C. Fargo, Janet E. Hall, Alison A. Motsinger-Reif
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:HGG Advances
Subjects:
hypertensive disorders of pregnancy
polygenic scores
preeclampsia
gestational hypertension
genome-wide associateion study (GWAS)
Personalized Environment and Genes Study (PEGS)
Online Access:http://www.sciencedirect.com/science/article/pii/S2666247724001258
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