The Identification Distinct Antiviral Factors Regulated Influenza Pandemic H1N1 Infection
Influenza pandemic with H1N1 (H1N1pdms) causes severe lung damage and “cytokine storm,” leading to higher mortality and global health emergencies in humans and animals. Explaining host antiviral molecular mechanisms in response to H1N1pdms is important for the development of novel therapies. In this...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | International Journal of Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2024/6631882 |
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| author | Baoxin Wang Hao Zheng Xia Dong Wenhua Zhang Junjing Wu Hongbo Chen Jing Zhang Ao Zhou |
| author_facet | Baoxin Wang Hao Zheng Xia Dong Wenhua Zhang Junjing Wu Hongbo Chen Jing Zhang Ao Zhou |
| author_sort | Baoxin Wang |
| collection | DOAJ |
| description | Influenza pandemic with H1N1 (H1N1pdms) causes severe lung damage and “cytokine storm,” leading to higher mortality and global health emergencies in humans and animals. Explaining host antiviral molecular mechanisms in response to H1N1pdms is important for the development of novel therapies. In this study, we organised and analysed multimicroarray data for mouse lungs infected with different H1N1pdm and nonpandemic H1N1 strains. We found that H1N1pdms infection resulted in a large proportion of differentially expressed genes (DEGs) in the infected lungs compared with normal lungs, and the number of DEGs increased markedly with the time of infection. In addition, we found that different H1N1pdm strains induced similarly innate immune responses and the identified DEGs during H1N1pdms infection were functionally concentrated in defence response to virus, cytokine-mediated signalling pathway, regulation of innate immune response, and response to interferon. Moreover, comparing with nonpandemic H1N1, we identified ten distinct DEGs (AREG, CXCL13, GATM, GPR171, IFI35, IFI47, IFIT3, ORM1, RETNLA, and UBD), which were enriched in immune response and cell surface receptor signalling pathway as well as interacted with immune response-related dysregulated genes during H1N1pdms. Our discoveries will provide comprehensive insights into host responding to pandemic with influenza H1N1 and find broad-spectrum effective treatment. |
| format | Article |
| id | doaj-art-fe201dabfa804632af7d1c7a94c5e199 |
| institution | OA Journals |
| issn | 1687-9198 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Microbiology |
| spelling | doaj-art-fe201dabfa804632af7d1c7a94c5e1992025-08-20T02:22:32ZengWileyInternational Journal of Microbiology1687-91982024-01-01202410.1155/2024/6631882The Identification Distinct Antiviral Factors Regulated Influenza Pandemic H1N1 InfectionBaoxin Wang0Hao Zheng1Xia Dong2Wenhua Zhang3Junjing Wu4Hongbo Chen5Jing Zhang6Ao Zhou7School of Animal Science and Nutritional EngineeringSchool of Animal Science and Nutritional EngineeringSchool of Animal Science and Nutritional EngineeringSchool of Animal Science and Nutritional EngineeringHubei Key Laboratory of Animal Embryo and Molecular BreedingSchool of Animal Science and Nutritional EngineeringSchool of Animal Science and Nutritional EngineeringSchool of Animal Science and Nutritional EngineeringInfluenza pandemic with H1N1 (H1N1pdms) causes severe lung damage and “cytokine storm,” leading to higher mortality and global health emergencies in humans and animals. Explaining host antiviral molecular mechanisms in response to H1N1pdms is important for the development of novel therapies. In this study, we organised and analysed multimicroarray data for mouse lungs infected with different H1N1pdm and nonpandemic H1N1 strains. We found that H1N1pdms infection resulted in a large proportion of differentially expressed genes (DEGs) in the infected lungs compared with normal lungs, and the number of DEGs increased markedly with the time of infection. In addition, we found that different H1N1pdm strains induced similarly innate immune responses and the identified DEGs during H1N1pdms infection were functionally concentrated in defence response to virus, cytokine-mediated signalling pathway, regulation of innate immune response, and response to interferon. Moreover, comparing with nonpandemic H1N1, we identified ten distinct DEGs (AREG, CXCL13, GATM, GPR171, IFI35, IFI47, IFIT3, ORM1, RETNLA, and UBD), which were enriched in immune response and cell surface receptor signalling pathway as well as interacted with immune response-related dysregulated genes during H1N1pdms. Our discoveries will provide comprehensive insights into host responding to pandemic with influenza H1N1 and find broad-spectrum effective treatment.http://dx.doi.org/10.1155/2024/6631882 |
| spellingShingle | Baoxin Wang Hao Zheng Xia Dong Wenhua Zhang Junjing Wu Hongbo Chen Jing Zhang Ao Zhou The Identification Distinct Antiviral Factors Regulated Influenza Pandemic H1N1 Infection International Journal of Microbiology |
| title | The Identification Distinct Antiviral Factors Regulated Influenza Pandemic H1N1 Infection |
| title_full | The Identification Distinct Antiviral Factors Regulated Influenza Pandemic H1N1 Infection |
| title_fullStr | The Identification Distinct Antiviral Factors Regulated Influenza Pandemic H1N1 Infection |
| title_full_unstemmed | The Identification Distinct Antiviral Factors Regulated Influenza Pandemic H1N1 Infection |
| title_short | The Identification Distinct Antiviral Factors Regulated Influenza Pandemic H1N1 Infection |
| title_sort | identification distinct antiviral factors regulated influenza pandemic h1n1 infection |
| url | http://dx.doi.org/10.1155/2024/6631882 |
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