Novel Insight of N6-Methyladenosine in Cardiovascular System
N6-methyladenosine (m6A) is the most common and abundant internal co-transcriptional modification in eukaryotic RNAs. This modification is catalyzed by m6A methyltransferases, known as “writers”, including <i>METTL3/14</i> and <i>WTAP</i>, and removed by demethylases, or “era...
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2025-01-01
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| author | Huan Zhang Wei Lu Haoyue Tang Aiqun Chen Xiaofei Gao Congfei Zhu Junjie Zhang |
| author_facet | Huan Zhang Wei Lu Haoyue Tang Aiqun Chen Xiaofei Gao Congfei Zhu Junjie Zhang |
| author_sort | Huan Zhang |
| collection | DOAJ |
| description | N6-methyladenosine (m6A) is the most common and abundant internal co-transcriptional modification in eukaryotic RNAs. This modification is catalyzed by m6A methyltransferases, known as “writers”, including <i>METTL3/14</i> and <i>WTAP</i>, and removed by demethylases, or “erasers”, such as <i>FTO</i> and <i>ALKBH5</i>. It is recognized by m6A-binding proteins, or “readers”, such as <i>YTHDF1/2/3</i>, <i>YTHDC1/2</i>, <i>IGF2BP1/2/3</i>, and <i>HNRNPA2B1</i>. Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide. Recent studies indicate that m6A RNA modification plays a critical role in both the physiological and pathological processes involved in the initiation and progression of CVDs. In this review, we will explore how m6A RNA methylation impacts both the normal and disease states of the cardiovascular system. Our focus will be on recent advancements in understanding the biological functions, molecular mechanisms, and regulatory factors of m6A RNA methylation, along with its downstream target genes in various CVDs, such as atherosclerosis, ischemic diseases, metabolic disorders, and heart failure. We propose that the m6A RNA methylation pathway holds promise as a potential therapeutic target in cardiovascular disease. |
| format | Article |
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| issn | 1010-660X 1648-9144 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| spelling | doaj-art-fe1ee3f055d04bbaa0bb9ef58599649c2025-08-20T03:12:19ZengMDPI AGMedicina1010-660X1648-91442025-01-0161222210.3390/medicina61020222Novel Insight of N6-Methyladenosine in Cardiovascular SystemHuan Zhang0Wei Lu1Haoyue Tang2Aiqun Chen3Xiaofei Gao4Congfei Zhu5Junjie Zhang6Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, ChinaDepartment of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, ChinaDepartment of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, ChinaDepartment of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, ChinaDepartment of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, ChinaDepartment of Cardiology, Lianshui County People’s Hospital, Affiliated Hospital of Kangda College, Nanjing Medical University, Huaian 223400, ChinaDepartment of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, ChinaN6-methyladenosine (m6A) is the most common and abundant internal co-transcriptional modification in eukaryotic RNAs. This modification is catalyzed by m6A methyltransferases, known as “writers”, including <i>METTL3/14</i> and <i>WTAP</i>, and removed by demethylases, or “erasers”, such as <i>FTO</i> and <i>ALKBH5</i>. It is recognized by m6A-binding proteins, or “readers”, such as <i>YTHDF1/2/3</i>, <i>YTHDC1/2</i>, <i>IGF2BP1/2/3</i>, and <i>HNRNPA2B1</i>. Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide. Recent studies indicate that m6A RNA modification plays a critical role in both the physiological and pathological processes involved in the initiation and progression of CVDs. In this review, we will explore how m6A RNA methylation impacts both the normal and disease states of the cardiovascular system. Our focus will be on recent advancements in understanding the biological functions, molecular mechanisms, and regulatory factors of m6A RNA methylation, along with its downstream target genes in various CVDs, such as atherosclerosis, ischemic diseases, metabolic disorders, and heart failure. We propose that the m6A RNA methylation pathway holds promise as a potential therapeutic target in cardiovascular disease.https://www.mdpi.com/1648-9144/61/2/222N6-methyladenosinecardiovascular systemischemia–hypoxia injuryatherosclerosisheart failure |
| spellingShingle | Huan Zhang Wei Lu Haoyue Tang Aiqun Chen Xiaofei Gao Congfei Zhu Junjie Zhang Novel Insight of N6-Methyladenosine in Cardiovascular System Medicina N6-methyladenosine cardiovascular system ischemia–hypoxia injury atherosclerosis heart failure |
| title | Novel Insight of N6-Methyladenosine in Cardiovascular System |
| title_full | Novel Insight of N6-Methyladenosine in Cardiovascular System |
| title_fullStr | Novel Insight of N6-Methyladenosine in Cardiovascular System |
| title_full_unstemmed | Novel Insight of N6-Methyladenosine in Cardiovascular System |
| title_short | Novel Insight of N6-Methyladenosine in Cardiovascular System |
| title_sort | novel insight of n6 methyladenosine in cardiovascular system |
| topic | N6-methyladenosine cardiovascular system ischemia–hypoxia injury atherosclerosis heart failure |
| url | https://www.mdpi.com/1648-9144/61/2/222 |
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