Evaluation of Lipid Profile and Troponin-I as Predictors of Cardiovascular Disorders among Young Adults in Ado-Ekiti
Cardiovascular diseases (CVDs) remain a leading cause of morbidity and mortality worldwide, presenting a significant public health challenge. It encompasses a spectrum of conditions affecting the heart or blood vessels. This study aimed to evaluate the Lipid Profile and Troponin-I as Predictors of C...
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Hammer Head Production Limited
2024-07-01
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| Series: | Sokoto Journal of Medical Laboratory Science |
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| Online Access: | https://sokjmls.com.ng/index.php/SJMLS/article/view/514 |
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| author | Victor Segun ADEOYE and Mathew Folaranmi OLANIYAN* |
| author_facet | Victor Segun ADEOYE and Mathew Folaranmi OLANIYAN* |
| author_sort | Victor Segun ADEOYE and Mathew Folaranmi OLANIYAN* |
| collection | DOAJ |
| description | Cardiovascular diseases (CVDs) remain a leading cause of morbidity and mortality worldwide, presenting a significant public health challenge. It encompasses a spectrum of conditions affecting the heart or blood vessels. This study aimed to evaluate the Lipid Profile and Troponin-I as Predictors of Cardiovascular Disorders among Young Adults in Ado-Ekiti, Nigeria. The objectives included investigating dyslipidemia and elevated Troponin - I prevalence, examining contributing factors, exploring Lipid profile-CVD risk associations, assessing Troponin-I-CVD risk factor correlations, and comparing predictive powers. Ethical approval and informed consent were obtained. Clinical assessments and blood samples were collected for Lipid Profile and Troponin-I analysis. A cross-sectional design was used with 384 participants aged 18-45 years. SPSS software was used for statistical analysis. The age distribution showed that 19.50% were aged 18 - 28, 45.60% were aged 28 - 38, and 34.90% fell within the 38 – 48 age range. The mean age and standard deviation for each age group were provided, with statistical tests indicating significant differences between the groups (p <0.05, F = 1217.461). Participants with “AT RISK” of CVD exhibited higher mean Cardiovascular Risk Ratio (CRR) scores (7.0341 ± 2.52) compared to those with “NO RISK” (3.1531 ± 0.34). Logistic regression analysis identified Total cholesterol as a significant predictor of CVD risk (B = 0.902, p < 0.05, Exponentiated Coefficient (B) = 2.464),
while Troponin-I did not significantly predict risk (B = -0.203, p = 0.366, Exponentiated Coefficient (B) = 0.816). Multivariate analysis demonstrated that the predictor variables collectively provided a good fit to the data (Wald = 62.048, df = 6, p < 0.05). Total cholesterol emerged as a significant CVD risk predictor. Troponin-I's role warrants further investigation. Findings emphasize the multifactorial nature of CVD risk and the importance of comprehensive assessments for accurate prediction and management. |
| format | Article |
| id | doaj-art-fe1d15ec08c541ebb1515a788c4e3154 |
| institution | Kabale University |
| issn | 2536-7153 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Hammer Head Production Limited |
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| series | Sokoto Journal of Medical Laboratory Science |
| spelling | doaj-art-fe1d15ec08c541ebb1515a788c4e31542025-08-20T03:39:48ZengHammer Head Production LimitedSokoto Journal of Medical Laboratory Science2536-71532024-07-019210.4314/sokjmls.v9i2.16514Evaluation of Lipid Profile and Troponin-I as Predictors of Cardiovascular Disorders among Young Adults in Ado-EkitiVictor Segun ADEOYE and Mathew Folaranmi OLANIYAN*Cardiovascular diseases (CVDs) remain a leading cause of morbidity and mortality worldwide, presenting a significant public health challenge. It encompasses a spectrum of conditions affecting the heart or blood vessels. This study aimed to evaluate the Lipid Profile and Troponin-I as Predictors of Cardiovascular Disorders among Young Adults in Ado-Ekiti, Nigeria. The objectives included investigating dyslipidemia and elevated Troponin - I prevalence, examining contributing factors, exploring Lipid profile-CVD risk associations, assessing Troponin-I-CVD risk factor correlations, and comparing predictive powers. Ethical approval and informed consent were obtained. Clinical assessments and blood samples were collected for Lipid Profile and Troponin-I analysis. A cross-sectional design was used with 384 participants aged 18-45 years. SPSS software was used for statistical analysis. The age distribution showed that 19.50% were aged 18 - 28, 45.60% were aged 28 - 38, and 34.90% fell within the 38 – 48 age range. The mean age and standard deviation for each age group were provided, with statistical tests indicating significant differences between the groups (p <0.05, F = 1217.461). Participants with “AT RISK” of CVD exhibited higher mean Cardiovascular Risk Ratio (CRR) scores (7.0341 ± 2.52) compared to those with “NO RISK” (3.1531 ± 0.34). Logistic regression analysis identified Total cholesterol as a significant predictor of CVD risk (B = 0.902, p < 0.05, Exponentiated Coefficient (B) = 2.464), while Troponin-I did not significantly predict risk (B = -0.203, p = 0.366, Exponentiated Coefficient (B) = 0.816). Multivariate analysis demonstrated that the predictor variables collectively provided a good fit to the data (Wald = 62.048, df = 6, p < 0.05). Total cholesterol emerged as a significant CVD risk predictor. Troponin-I's role warrants further investigation. Findings emphasize the multifactorial nature of CVD risk and the importance of comprehensive assessments for accurate prediction and management.https://sokjmls.com.ng/index.php/SJMLS/article/view/514lipid profile, troponin-i, cardiovascular disorders, young adults, ado-ekiti |
| spellingShingle | Victor Segun ADEOYE and Mathew Folaranmi OLANIYAN* Evaluation of Lipid Profile and Troponin-I as Predictors of Cardiovascular Disorders among Young Adults in Ado-Ekiti Sokoto Journal of Medical Laboratory Science lipid profile, troponin-i, cardiovascular disorders, young adults, ado-ekiti |
| title | Evaluation of Lipid Profile and Troponin-I as Predictors of Cardiovascular Disorders among Young Adults in Ado-Ekiti |
| title_full | Evaluation of Lipid Profile and Troponin-I as Predictors of Cardiovascular Disorders among Young Adults in Ado-Ekiti |
| title_fullStr | Evaluation of Lipid Profile and Troponin-I as Predictors of Cardiovascular Disorders among Young Adults in Ado-Ekiti |
| title_full_unstemmed | Evaluation of Lipid Profile and Troponin-I as Predictors of Cardiovascular Disorders among Young Adults in Ado-Ekiti |
| title_short | Evaluation of Lipid Profile and Troponin-I as Predictors of Cardiovascular Disorders among Young Adults in Ado-Ekiti |
| title_sort | evaluation of lipid profile and troponin i as predictors of cardiovascular disorders among young adults in ado ekiti |
| topic | lipid profile, troponin-i, cardiovascular disorders, young adults, ado-ekiti |
| url | https://sokjmls.com.ng/index.php/SJMLS/article/view/514 |
| work_keys_str_mv | AT victorsegunadeoyeandmathewfolaranmiolaniyan evaluationoflipidprofileandtroponiniaspredictorsofcardiovasculardisordersamongyoungadultsinadoekiti |