Diverse Applications of the Anti-Diabetic Drug Metformin in Treating Human Disease
Metformin is a commonly used drug for treating type 2 diabetes. Metformin is an inexpensive drug with low/no side effects and is well tolerated in human patients of different ages. Recent therapeutic strategies for human disease have considered the benefits of drug repurposing. This includes the use...
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MDPI AG
2024-11-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/17/12/1601 |
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| author | Chris-Tiann Roberts Nicole Raabe Lara Wiegand Ashraf Kadar Shahib Mojgan Rastegar |
| author_facet | Chris-Tiann Roberts Nicole Raabe Lara Wiegand Ashraf Kadar Shahib Mojgan Rastegar |
| author_sort | Chris-Tiann Roberts |
| collection | DOAJ |
| description | Metformin is a commonly used drug for treating type 2 diabetes. Metformin is an inexpensive drug with low/no side effects and is well tolerated in human patients of different ages. Recent therapeutic strategies for human disease have considered the benefits of drug repurposing. This includes the use of the anti-diabetic drug metformin. Accordingly, the anti-inflammatory, anti-cancer, anti-viral, neuroprotective, and cardioprotective potentials of metformin have deemed it a suitable candidate for treating a plethora of human diseases. As results from preclinical studies using cellular and animal model systems appear promising, clinical trials with metformin in the context of non-diabetes-related illnesses have been started. Here, we aim to provide a comprehensive overview of the therapeutic potential of metformin in different animal models of human disease and its suggested relationship to epigenetics and ailments with epigenetic components. |
| format | Article |
| id | doaj-art-fe1840f4f5d94ef5adcbdfbe6c0965dc |
| institution | DOAJ |
| issn | 1424-8247 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj-art-fe1840f4f5d94ef5adcbdfbe6c0965dc2025-08-20T02:56:51ZengMDPI AGPharmaceuticals1424-82472024-11-011712160110.3390/ph17121601Diverse Applications of the Anti-Diabetic Drug Metformin in Treating Human DiseaseChris-Tiann Roberts0Nicole Raabe1Lara Wiegand2Ashraf Kadar Shahib3Mojgan Rastegar4Department of Biochemistry and Medical Genetics, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0J9, CanadaDepartment of Biochemistry and Medical Genetics, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0J9, CanadaDepartment of Biochemistry and Medical Genetics, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0J9, CanadaDepartment of Biochemistry and Medical Genetics, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0J9, CanadaDepartment of Biochemistry and Medical Genetics, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 0J9, CanadaMetformin is a commonly used drug for treating type 2 diabetes. Metformin is an inexpensive drug with low/no side effects and is well tolerated in human patients of different ages. Recent therapeutic strategies for human disease have considered the benefits of drug repurposing. This includes the use of the anti-diabetic drug metformin. Accordingly, the anti-inflammatory, anti-cancer, anti-viral, neuroprotective, and cardioprotective potentials of metformin have deemed it a suitable candidate for treating a plethora of human diseases. As results from preclinical studies using cellular and animal model systems appear promising, clinical trials with metformin in the context of non-diabetes-related illnesses have been started. Here, we aim to provide a comprehensive overview of the therapeutic potential of metformin in different animal models of human disease and its suggested relationship to epigenetics and ailments with epigenetic components.https://www.mdpi.com/1424-8247/17/12/1601metformindrug repurposingepigeneticshuman diseasetype 2 diabetes |
| spellingShingle | Chris-Tiann Roberts Nicole Raabe Lara Wiegand Ashraf Kadar Shahib Mojgan Rastegar Diverse Applications of the Anti-Diabetic Drug Metformin in Treating Human Disease Pharmaceuticals metformin drug repurposing epigenetics human disease type 2 diabetes |
| title | Diverse Applications of the Anti-Diabetic Drug Metformin in Treating Human Disease |
| title_full | Diverse Applications of the Anti-Diabetic Drug Metformin in Treating Human Disease |
| title_fullStr | Diverse Applications of the Anti-Diabetic Drug Metformin in Treating Human Disease |
| title_full_unstemmed | Diverse Applications of the Anti-Diabetic Drug Metformin in Treating Human Disease |
| title_short | Diverse Applications of the Anti-Diabetic Drug Metformin in Treating Human Disease |
| title_sort | diverse applications of the anti diabetic drug metformin in treating human disease |
| topic | metformin drug repurposing epigenetics human disease type 2 diabetes |
| url | https://www.mdpi.com/1424-8247/17/12/1601 |
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