CAR T Cell Therapy: A Game Changer in Cancer Treatment
The development of novel targeted therapies with acceptable safety profiles is critical to successful cancer outcomes with better survival rates. Immunotherapy offers promising opportunities with the potential to induce sustained remissions in patients with refractory disease. Recent dramatic clinic...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2016/5474602 |
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| _version_ | 1849521466924597248 |
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| author | Hilde Almåsbak Tanja Aarvak Mohan C. Vemuri |
| author_facet | Hilde Almåsbak Tanja Aarvak Mohan C. Vemuri |
| author_sort | Hilde Almåsbak |
| collection | DOAJ |
| description | The development of novel targeted therapies with acceptable safety profiles is critical to successful cancer outcomes with better survival rates. Immunotherapy offers promising opportunities with the potential to induce sustained remissions in patients with refractory disease. Recent dramatic clinical responses in trials with gene modified T cells expressing chimeric antigen receptors (CARs) in B-cell malignancies have generated great enthusiasm. This therapy might pave the way for a potential paradigm shift in the way we treat refractory or relapsed cancers. CARs are genetically engineered receptors that combine the specific binding domains from a tumor targeting antibody with T cell signaling domains to allow specifically targeted antibody redirected T cell activation. Despite current successes in hematological cancers, we are only in the beginning of exploring the powerful potential of CAR redirected T cells in the control and elimination of resistant, metastatic, or recurrent nonhematological cancers. This review discusses the application of the CAR T cell therapy, its challenges, and strategies for successful clinical and commercial translation. |
| format | Article |
| id | doaj-art-fe17f4c059644100a362a03b95afcaf3 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-fe17f4c059644100a362a03b95afcaf32025-08-20T03:25:46ZengWileyJournal of Immunology Research2314-88612314-71562016-01-01201610.1155/2016/54746025474602CAR T Cell Therapy: A Game Changer in Cancer TreatmentHilde Almåsbak0Tanja Aarvak1Mohan C. Vemuri2Cellular Medicine, Bioproduction, Thermo Fisher Scientific, 0309 Oslo, NorwayCellular Medicine, Bioproduction, Thermo Fisher Scientific, 0309 Oslo, NorwayCell Biology, Thermo Fisher Scientific, Frederick, MD 21704, USAThe development of novel targeted therapies with acceptable safety profiles is critical to successful cancer outcomes with better survival rates. Immunotherapy offers promising opportunities with the potential to induce sustained remissions in patients with refractory disease. Recent dramatic clinical responses in trials with gene modified T cells expressing chimeric antigen receptors (CARs) in B-cell malignancies have generated great enthusiasm. This therapy might pave the way for a potential paradigm shift in the way we treat refractory or relapsed cancers. CARs are genetically engineered receptors that combine the specific binding domains from a tumor targeting antibody with T cell signaling domains to allow specifically targeted antibody redirected T cell activation. Despite current successes in hematological cancers, we are only in the beginning of exploring the powerful potential of CAR redirected T cells in the control and elimination of resistant, metastatic, or recurrent nonhematological cancers. This review discusses the application of the CAR T cell therapy, its challenges, and strategies for successful clinical and commercial translation.http://dx.doi.org/10.1155/2016/5474602 |
| spellingShingle | Hilde Almåsbak Tanja Aarvak Mohan C. Vemuri CAR T Cell Therapy: A Game Changer in Cancer Treatment Journal of Immunology Research |
| title | CAR T Cell Therapy: A Game Changer in Cancer Treatment |
| title_full | CAR T Cell Therapy: A Game Changer in Cancer Treatment |
| title_fullStr | CAR T Cell Therapy: A Game Changer in Cancer Treatment |
| title_full_unstemmed | CAR T Cell Therapy: A Game Changer in Cancer Treatment |
| title_short | CAR T Cell Therapy: A Game Changer in Cancer Treatment |
| title_sort | car t cell therapy a game changer in cancer treatment |
| url | http://dx.doi.org/10.1155/2016/5474602 |
| work_keys_str_mv | AT hildealmasbak cartcelltherapyagamechangerincancertreatment AT tanjaaarvak cartcelltherapyagamechangerincancertreatment AT mohancvemuri cartcelltherapyagamechangerincancertreatment |