Modulation of the Neuro–Cancer Connection by Metabolites of Gut Microbiota
The gut–brain–cancer axis represents a novel and intricate connection between the gut microbiota, neurobiology, and cancer progression. Recent advances have accentuated the significant role of gut microbiota metabolites in modulating systemic processes that influence both brain health and tumorigene...
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| Language: | English |
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MDPI AG
2025-02-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/15/2/270 |
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| author | Alice N. Mafe Dietrich Büsselberg |
| author_facet | Alice N. Mafe Dietrich Büsselberg |
| author_sort | Alice N. Mafe |
| collection | DOAJ |
| description | The gut–brain–cancer axis represents a novel and intricate connection between the gut microbiota, neurobiology, and cancer progression. Recent advances have accentuated the significant role of gut microbiota metabolites in modulating systemic processes that influence both brain health and tumorigenesis. This paper explores the emerging concept of metabolite-mediated modulation within the gut–brain–cancer connection, focusing on key metabolites such as short-chain fatty acids (SCFAs), tryptophan derivatives, secondary bile acids, and lipopolysaccharides (LPS). While the gut microbiota’s impact on immune regulation, neuroinflammation, and tumor development is well established, gaps remain in grasping how specific metabolites contribute to neuro–cancer interactions. We discuss novel metabolites with potential implications for neurobiology and cancer, such as indoles and polyamines, which have yet to be extensively studied. Furthermore, we review preclinical and clinical evidence linking gut dysbiosis, altered metabolite profiles, and brain tumors, showcasing limitations and research gaps, particularly in human longitudinal studies. Case studies investigating microbiota-based interventions, including dietary changes, fecal microbiota transplantation, and probiotics, demonstrate promise but also indicate hurdles in translating these findings to clinical cancer therapies. This paper concludes with a call for standardized multi-omics approaches and bi-directional research frameworks integrating microbiome, neuroscience, and oncology to develop personalized therapeutic strategies for neuro-cancer patients. |
| format | Article |
| id | doaj-art-fe14d23ef4e54d30973da15a41b8b4e1 |
| institution | DOAJ |
| issn | 2218-273X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-fe14d23ef4e54d30973da15a41b8b4e12025-08-20T03:11:59ZengMDPI AGBiomolecules2218-273X2025-02-0115227010.3390/biom15020270Modulation of the Neuro–Cancer Connection by Metabolites of Gut MicrobiotaAlice N. Mafe0Dietrich Büsselberg1Department of Biological Sciences, Faculty of Sciences, Taraba State University, Main Campus, Jalingo 660101, Taraba State, NigeriaWeill Cornell Medicine-Qatar, Education City, Qatar Foundation, Doha Metropolitan Area, Doha P.O. Box 22104, QatarThe gut–brain–cancer axis represents a novel and intricate connection between the gut microbiota, neurobiology, and cancer progression. Recent advances have accentuated the significant role of gut microbiota metabolites in modulating systemic processes that influence both brain health and tumorigenesis. This paper explores the emerging concept of metabolite-mediated modulation within the gut–brain–cancer connection, focusing on key metabolites such as short-chain fatty acids (SCFAs), tryptophan derivatives, secondary bile acids, and lipopolysaccharides (LPS). While the gut microbiota’s impact on immune regulation, neuroinflammation, and tumor development is well established, gaps remain in grasping how specific metabolites contribute to neuro–cancer interactions. We discuss novel metabolites with potential implications for neurobiology and cancer, such as indoles and polyamines, which have yet to be extensively studied. Furthermore, we review preclinical and clinical evidence linking gut dysbiosis, altered metabolite profiles, and brain tumors, showcasing limitations and research gaps, particularly in human longitudinal studies. Case studies investigating microbiota-based interventions, including dietary changes, fecal microbiota transplantation, and probiotics, demonstrate promise but also indicate hurdles in translating these findings to clinical cancer therapies. This paper concludes with a call for standardized multi-omics approaches and bi-directional research frameworks integrating microbiome, neuroscience, and oncology to develop personalized therapeutic strategies for neuro-cancer patients.https://www.mdpi.com/2218-273X/15/2/270gut microbiotaneuro–cancer connectionmicrobial metabolitesgut–brain axis and immune modulation |
| spellingShingle | Alice N. Mafe Dietrich Büsselberg Modulation of the Neuro–Cancer Connection by Metabolites of Gut Microbiota Biomolecules gut microbiota neuro–cancer connection microbial metabolites gut–brain axis and immune modulation |
| title | Modulation of the Neuro–Cancer Connection by Metabolites of Gut Microbiota |
| title_full | Modulation of the Neuro–Cancer Connection by Metabolites of Gut Microbiota |
| title_fullStr | Modulation of the Neuro–Cancer Connection by Metabolites of Gut Microbiota |
| title_full_unstemmed | Modulation of the Neuro–Cancer Connection by Metabolites of Gut Microbiota |
| title_short | Modulation of the Neuro–Cancer Connection by Metabolites of Gut Microbiota |
| title_sort | modulation of the neuro cancer connection by metabolites of gut microbiota |
| topic | gut microbiota neuro–cancer connection microbial metabolites gut–brain axis and immune modulation |
| url | https://www.mdpi.com/2218-273X/15/2/270 |
| work_keys_str_mv | AT alicenmafe modulationoftheneurocancerconnectionbymetabolitesofgutmicrobiota AT dietrichbusselberg modulationoftheneurocancerconnectionbymetabolitesofgutmicrobiota |