Precise nanoscale fabrication technologies, the “last mile” of medicinal development
Nanotechnologies seek to overcome inherent deficiencies of conventional diagnosis and treatment, which attracted sustained attention and a limited number of nanomedicines approved by the FDA. However, the critical gaps in clinical translation remain, and nanomedicines that were initially heralded as...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-05-01
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| Series: | Acta Pharmaceutica Sinica B |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383525001807 |
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| author | Ye Bi Sensen Xie Ziwei Li Shiyan Dong Lesheng Teng |
| author_facet | Ye Bi Sensen Xie Ziwei Li Shiyan Dong Lesheng Teng |
| author_sort | Ye Bi |
| collection | DOAJ |
| description | Nanotechnologies seek to overcome inherent deficiencies of conventional diagnosis and treatment, which attracted sustained attention and a limited number of nanomedicines approved by the FDA. However, the critical gaps in clinical translation remain, and nanomedicines that were initially heralded as magic bullets have yet to reach their realistic potential. The major obstacles of fabrication technologies may be overlooked in the nanoparticles’ journey. Suboptimal manufacturing strategies partly hampered the inefficient transformation. In this review, we discuss the nanoparticle manufacturing strategies of “Top-Down” and “Bottom-Up” on precise nanoscale fabrication, including artificial intelligence introduced to guided nanomedicine fabrication for accelerating the transformation. Re-engineering existing nanomedicine fabrication, individual manufacturing, and modular technology might highlight the dilemmas of nanomedicines to meet their initial expectations. |
| format | Article |
| id | doaj-art-fe14c706635d48bca813dfc8fafc8f2c |
| institution | DOAJ |
| issn | 2211-3835 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Acta Pharmaceutica Sinica B |
| spelling | doaj-art-fe14c706635d48bca813dfc8fafc8f2c2025-08-20T03:09:57ZengElsevierActa Pharmaceutica Sinica B2211-38352025-05-011552372240110.1016/j.apsb.2025.03.040Precise nanoscale fabrication technologies, the “last mile” of medicinal developmentYe Bi0Sensen Xie1Ziwei Li2Shiyan Dong3Lesheng Teng4Practice Training Center, Changchun University of Chinese Medicine, Changchun 130117, China; Public Experimental Center, Changchun University of Chinese Medicine, Changchun 130117, ChinaSchool of Life Sciences, Jilin University, Changchun 130012, ChinaSchool of Life Sciences, Jilin University, Changchun 130012, ChinaSchool of Life Sciences, Jilin University, Changchun 130012, China; Department of Radiation Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Corresponding authors.School of Life Sciences, Jilin University, Changchun 130012, China; Corresponding authors.Nanotechnologies seek to overcome inherent deficiencies of conventional diagnosis and treatment, which attracted sustained attention and a limited number of nanomedicines approved by the FDA. However, the critical gaps in clinical translation remain, and nanomedicines that were initially heralded as magic bullets have yet to reach their realistic potential. The major obstacles of fabrication technologies may be overlooked in the nanoparticles’ journey. Suboptimal manufacturing strategies partly hampered the inefficient transformation. In this review, we discuss the nanoparticle manufacturing strategies of “Top-Down” and “Bottom-Up” on precise nanoscale fabrication, including artificial intelligence introduced to guided nanomedicine fabrication for accelerating the transformation. Re-engineering existing nanomedicine fabrication, individual manufacturing, and modular technology might highlight the dilemmas of nanomedicines to meet their initial expectations.http://www.sciencedirect.com/science/article/pii/S2211383525001807NanomedicinesFabrication technologiesExtracellular vesiclesMicrofluidicsDNA origami3D printing |
| spellingShingle | Ye Bi Sensen Xie Ziwei Li Shiyan Dong Lesheng Teng Precise nanoscale fabrication technologies, the “last mile” of medicinal development Acta Pharmaceutica Sinica B Nanomedicines Fabrication technologies Extracellular vesicles Microfluidics DNA origami 3D printing |
| title | Precise nanoscale fabrication technologies, the “last mile” of medicinal development |
| title_full | Precise nanoscale fabrication technologies, the “last mile” of medicinal development |
| title_fullStr | Precise nanoscale fabrication technologies, the “last mile” of medicinal development |
| title_full_unstemmed | Precise nanoscale fabrication technologies, the “last mile” of medicinal development |
| title_short | Precise nanoscale fabrication technologies, the “last mile” of medicinal development |
| title_sort | precise nanoscale fabrication technologies the last mile of medicinal development |
| topic | Nanomedicines Fabrication technologies Extracellular vesicles Microfluidics DNA origami 3D printing |
| url | http://www.sciencedirect.com/science/article/pii/S2211383525001807 |
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